Métabolisme des dérivés guanidylés

Comparative Physiology: Fuel of Muscle Metabolism

“…Thoai et al (144) have identified phosphotaurocyamine in Arenicola marina and Sabellaria alveolata and phosphoglycocyamine in Nereis diversicolor and sev eral other polychaetes. These workers in addition have isolated another phosphagen, phospholombricine (guanidoethylseryl phosphate), from the muscle of the earthworm Lumbricus terrestris (136,145,146). The presence of yet another monosubstituted guanidine, hirudonine, from the muscle of the leech Hirudo medicinalis (147,148) suggests that it · may play the part of a phosphate acceptor in this organism.…”

The isolation of lombricine and its possible biological precursor

“…Detection of the possible lombricine precursor The proposed structure of lombricine (Van Thoai & Robin, 1954) suggests that the corresponding amine, SEP, may be the biological precursor of lombricine, which could be formed from the former compound by a transamidination reaction involving arginine. Such a suggestion has already been made (Ennor & Morrison, 1958).…”

“…In connexion with experiments on the chemical and biological synthesis of 2-guanidinoethyl 2-amino-2-carboxyethyl hydrogen phosphate (lombricine) it was desirable to have, as a reference compound, adequate amounts of the naturally occurring material. The isolation of lombricine from the earthworm (Lumbricu8 terre8tri8) has been described by Van Thoai & Robin (1954), but the low yield reported stimulated a search for an improved method. The simplified procedure described in this paper results in much greater yields of analytically pure material.…”

The distribution of guanidines, phosphagens and N-amidino phosphokinases in echinoids

“…Moreover, other phosphorylated guanidines, e.g. phosphotaurocyamine, phosphoglycocyamine and phospholombricine, also occur in invertebrate muscle (Thoai, Roche, Robin & Thiem, 1953 a;Thoai & Robin, 1954).…”