Metabolism of volatile fatty acids by liver and portal-drained viscera in sheep

Bergman, E. N.; Wolff, J.

doi:10.1152/ajplegacy.1971.221.2.586

Cited by 215 publications

(114 citation statements)

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“…Overall, 12 studies were kept, of which six were for Below Maintenance and six for Above Maintenance analyses (Table 1, Appendix). Animals were either fasted for 3 days (Katz and Bergman, 1969;Bergman et al, 1970;Bergman and Wolff, 1971;Heitman et al, 1986) or fed at 0.5 or 1 times maintenance (Ortigues et al, 1994). In both groups, 83% of the animals were non-producing adults.…”

Section: Resultsmentioning

confidence: 99%

“…The contribution of hepatic arterial to hepatic venous (hepatic arterial/venous) blood flow, as calculated from portal and hepatic venous blood flow data reported in the literature, has shown varied response to increased metabolisable energy intake (MEI). When MEI was increased, the hepatic arterial/venous blood flow decreased numerically (Katz and Bergman, 1969;Bergman and Wolff, 1971;Heitman et al, 1986), remained unchanged (Freetly et al, 1995) or increased numerically (Burrin et al, 1991), depending on the study.…”

Section: Introductionmentioning

confidence: 97%

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Responses of hepatic blood flows to changes in intake in sheep: a meta-analysis

Vernet

Nozière²,

Léger³

et al. 2009

Animal

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This work set out to establish the response equations for hepatic blood flows in sheep and the contribution of hepatic arterial flow to hepatic venous blood flow due to changes in intake levels at constant diet composition. The FLORA (FLuxes across Organs and tissues in Ruminant Animals) database was used, and meta-analysis performed. The meta-analysis involved selection of published papers, identification of studies, description and coding of the selected dataset and statistical analysis using a covariance model. Meta-analyses were carried out using a within-study approach. To ensure absence of bias, the analysis incorporated interfering variables and factors studied in between-study comparisons. Variables concerned diet composition; qualitative factors concerned the physiological state of the animals and the methods used to measure blood flow. The results obtained showed that hepatic blood flows were positively related to intake in sheep. The magnitude of the response (as indicated by the slope) varied with the level of intake and the blood vessel (portal, hepatic venous or arterial). Nine linear relationships were established for the portal, hepatic venous and arterial blood flows as a function of dry matter intake (DMI) with below-and above-maintenance levels considered separately. Data obtained at below-and above-maintenance levels were considered together and four quadratic relationships were established for hepatic blood flows as a function of DMI. These relationships expressed a strong effect of intake on hepatic blood flows. The contribution of hepatic arterial to hepatic venous blood flow averaged 18.2%, with a wide variability. It did not vary significantly with level of intake. Although in between-study comparisons the arterial/venous blood flow was positively influenced by the organic matter digestibility of the diet, the relationships we obtained were robust. They can be used in models of net hepatic nutrient fluxes to predict variations and absolute values of hepatic blood flows from variations and absolute values of DMI.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Responses of hepatic blood flows to changes in intake in sheep: a meta-analysis

Vernet

Nozière²,

Léger³

et al. 2009

Animal

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“…Moreover, intraruminal and intravenous infusions of propionate have been shown to increase plasma insulin concentrations in ruminants [2,5,11]. Therefore, supplemental propionate seemed to influence glucose metabolism in the whole-body and its endocrine control.…”

Section: Discussionmentioning

confidence: 99%

“…Deux techniques de clamp glycémique ont été utilisées pendant 6 h, à partir de 2 h avant le début de la prise d'aliments pour étudier l'effet d'un supplément alimentaire de propionate sur la réaction insulinique et la réaction tissulaire à l'insuline en rapport avec l'alimentation chez des béliers. Les [2,5,11]. The VFA molar ratio in the rumen has previously been changed by switching from low to high concentrate diets in lambs [10].…”

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The effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep

Sano

Terashima²

1998

Reprod. Nutr. Dev.

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“…Because of the anatomical position of PDV, metabolism of these tissues is sustained by the supply of both endproducts of digestion and arterial-blood metabolites, as shown for acetate (Bergman & Wolff, 1971;Seal & Reynolds, 1993), glucose (Piccioli Cappelli et al 1993) and amino acids (MacRae et al 1993). Of the total endogenous plus dietary (endproducts of digestion, assimilated to MEI) energy supply to PDV, 83-87% is of endogenous origin.…”

Section: Nutrient Supply To the Portal-drained Visceramentioning

confidence: 99%