Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study

Balasubramanian, Krithika; Kumar, Sandeep; Singh, Rajeev R.; Sharma, Uma; Ahuja, Vineet; Makharia, Govind; Jagannathan, Naranamangalam R.

doi:10.1016/j.mri.2008.05.014

Cited by 85 publications

(91 citation statements)

References 33 publications

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“…A number of other studies on colonic biopsies have also demonstrated the ability of metabolomics to distinguish CD from UC. 272,273 A subgroup analysis in the Williams et al study 271 did not reveal any significant variation of the individual diseases by disease location, which is in contrast to Jansson et al, 267 who were able to show a difference in the fecal metabolite profiles of ileal versus colonic CD. Regarding disease activity, Jansson et al did not find any influence of disease activity on the metabolic profile; however, other studies have found that the activity of IBD could be distinguished on the basis of altered metabolite levels.…”

Section: Metabolomics: Metabolitesmentioning

confidence: 71%

“…Regarding disease activity, Jansson et al did not find any influence of disease activity on the metabolic profile; however, other studies have found that the activity of IBD could be distinguished on the basis of altered metabolite levels. 255,272 Metabolic profiles of colonic biopsies in IBD has shown that there was little difference between inflamed and noninflamed tissue, but the metabolic profiles differed from that of healthy controls. 274 In summary, the rapid development of extensive datasets of the genetic potential resident within various gut microbiomes should soon result in the next wave of highimpact discoveries, which elucidate not only the structural, but also the functional attributes of the gut microbiota that contribute to health and/or disease.…”

Section: Metabolomics: Metabolitesmentioning

confidence: 99%

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Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Cruz

Prideaux

Wagner

et al. 2012

Inflammatory Bowel Diseases

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The enteric bacterial flora play a key role in maintaining health. Inflammatory bowel disease is associated with quantitative and qualitative alterations in the microbiota. Early characterization of the microbiota involved culture-dependent techniques. The advent of metagenomic techniques, however, allows for structural and functional characterization using culture-independent methods. Changes in diversity, together with quantitative alterations in specific bacterial species, have been identified. The functional significance of these changes, and their pathogenic role, remain to be elucidated.

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Section: Metabolomics: Metabolitesmentioning

confidence: 71%

Section: Metabolomics: Metabolitesmentioning

confidence: 99%

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Cruz

Prideaux

Wagner

et al. 2012

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

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“…As described in IBD there are detectable metabolic changes at the onset of the disease and significant differences between active disease and remission [28,31]. In future, metabonomics might be a valuable tool in early diagnosis and in treatment monitoring.…”

Section: Discussionmentioning

confidence: 91%

“…CD and UC are the two most prevalent inflammatory bowel diseases. There are two studies investigating fecal extracts and colonic biopsies from affected patients [27,28]. A mouse model for IBD showing chronic enterocolitis has been described in 1993, which is based on knock-out of the interleukin 10 gene [29].…”

Section: Inflammatory Bowel Disease -Crohn's Disease and Ulcerative Cmentioning

confidence: 99%

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Metabolic Changes in Autoimmune Diseases

Seeger

2009

CDDT

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Metabolomics is a recently emerging member of the "omics" technologies. It aims at detecting and quantifying all detectable small molecules, the so-called metabolites, present in a biological sample. Because of the lower number of metabolites compared with the number of genes and proteins identified in genomics and proteomics approaches, data of metabolic studies are less complex and may therefore be more informative. Metabolomics may thus significantly contribute to our understanding of disease mechanisms. Autoimmune diseases are of growing clinical relevance, and due to the chronic nature of these diseases successful treatment is often challenging. In the past years, a variety of studies have been published about the metabolome of autoimmune diseases such as Crohn's disease and rheumatoid arthritis. However, our understanding of the role of different metabolites in the pathogenesis of autoimmune diseases is still far from being complete.

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Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis

Liu,

Li,

et al. 2024

Cancer Medicine

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Radiation enteropathy (RE) is common in patients treated with radiotherapy for pelvic–abdominal cancers. Accumulating data indicate that gut commensal bacteria determine intestinal radiosensitivity. Radiotherapy can result in gut bacterial dysbiosis. Gut bacterial dysbiosis contributes to the pathogenesis of RE. Mild to moderate depressive symptoms can be observed in patients with RE in clinical settings; however, the rate of these symptoms has not been reported. Studies have demonstrated that gut bacterial dysbiosis induces depression. In the state of comorbidity, RE and depression may be understood as local and abscopal manifestations of gut bacterial disorders. The ability of comorbid depression to worsen inflammatory bowel disease (IBD) has long been demonstrated and is associated with dysfunction of cholinergic neural anti‐inflammatory pathways. There is a lack of direct evidence for RE comorbid with depression. It is widely accepted that RE shares similar pathophysiologic mechanisms with IBD. Therefore, we may be able to draw on the findings of the relationship between IBD and depression. This review will explore the relationship between gut bacteria, RE, and depression in light of the available evidence and indicate a method for investigating the mechanisms of RE combined with depression. We will also describe new developments in the treatment of RE with probiotics, prebiotics, and fecal microbial transplantation.

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Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study

Cited by 85 publications

References 33 publications

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Metabolic Changes in Autoimmune Diseases

Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis

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