Metabolism of [ring-U-14C] agaritine by precision-cut rat, mouse and human liver and lung slices

Fate of the Mushroom Hydrazine Agaritine in the Rat and Mouse

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Fate of the Mushroom Hydrazine Agaritine in the Rat and Mouse

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In vitrolung slices: a powerful approach for assessment of lung pathophysiology

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Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

“…A widely applicable analytical method for the detection of agaritine and its metabolites is required in order to assess the risk posed by phenylhydrazine agaritine to humans. The presence of agaritine degradation products in food and agaritine metabolites in plasma from agaritine-administration in mice or rats, as the toxicities of these molecules, remains unclear, although the presence of unidentified agaritine metabolites were reported in both of these experimental cases [13,15].…”

Fate of the Mushroom Hydrazine Agaritine in the Rat and Mouse

“……”

In vitrolung slices: a powerful approach for assessment of lung pathophysiology

“……”

Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

“…A widely applicable analytical method for the detection of agaritine and its metabolites is required in order to assess the risk posed by phenylhydrazine agaritine to humans. The presence of agaritine degradation products in food and agaritine metabolites in plasma from agaritine-administration in mice or rats, as the toxicities of these molecules, remains unclear, although the presence of unidentified agaritine metabolites were reported in both of these experimental cases [13,15].…”

Fate of the Mushroom Hydrazine Agaritine in the Rat and Mouse

“……”

In vitrolung slices: a powerful approach for assessment of lung pathophysiology

“……”

Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

“…A widely applicable analytical method for the detection of agaritine and its metabolites is required in order to assess the risk posed by phenylhydrazine agaritine to humans. The presence of agaritine degradation products in food and agaritine metabolites in plasma from agaritine-administration in mice or rats, as the toxicities of these molecules, remains unclear, although the presence of unidentified agaritine metabolites were reported in both of these experimental cases [13,15].…”