Metabolism of [ring-U-14C] agaritine by precision-cut rat, mouse and human liver and lung slices

Price, Roger J.; Walters, D. Gareth; Hoff, C.; Mistry, H.; Renwick, A.B.; Wield, P.T.; Beamand, J.A.; Lake, Brian G.

doi:10.1016/0278-6915(96)00026-9

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…However, species selection should be tailored to the specific question or application. For example, a study comparing lung slices from rat and mouse with regard to the metabolism of 7-ethoxycoumarin and agartine found that slices from both species metabolized these drugs, but with some differences [38].…”

Section: Applicationsmentioning

confidence: 99%

In vitrolung slices: a powerful approach for assessment of lung pathophysiology

Liberati

Randle

Toth

2010

Expert Review of Molecular Diagnostics

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This review summarizes the existing literature on the use of in vitro lung slices to study pulmonary physiology, pharmacology, pathogenesis and toxicity. Since in vitro lung slices maintain cell-cell and cell-matrix relationships in a highly controllable and accessible setting, they offer many advantages over both in vivo and single-cell culture systems. With the advent of high-production slicers, lung slices can be rapidly and reproducibly generated, including from animals treated in vivo. Slices can then be treated in vitro and analyzed using high-throughput technology. Therefore, the lung-slice system offers broad, current and unrealized potential for the detection of toxicity and the delineation of pathophysiologic and therapeutic mechanisms.

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Section: Applicationsmentioning

confidence: 99%

In vitrolung slices: a powerful approach for assessment of lung pathophysiology

Liberati

Randle

Toth

2010

Expert Review of Molecular Diagnostics

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“…A widely applicable analytical method for the detection of agaritine and its metabolites is required in order to assess the risk posed by phenylhydrazine agaritine to humans. The presence of agaritine degradation products in food and agaritine metabolites in plasma from agaritine-administration in mice or rats, as the toxicities of these molecules, remains unclear, although the presence of unidentified agaritine metabolites were reported in both of these experimental cases [13,15].…”

Section: Introductionmentioning

confidence: 94%

“…HMPH and HMBD are highly unstable and are carcinogenic [10,12,14]. Price et al reported that agaritine was metabolized to compounds that covalently bond to proteins [15]. Shephard et al demonstrated covalent bonding between agaritine and DNA [16].…”

Section: Introductionmentioning

confidence: 98%

Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

Kondo¹,

Watanabe²,

Iwanaga³

et al. 2006

Journal of Chromatography B

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“…They have been applied in pharmacological and toxicological studies (Fisher & Placke 1987; Fisher et al 1994; Parrish et al 1995; Bach et al 1996; Monteil et al 1999; Catania et al 2007; Sturton et al 2008; Nassimi et al 2009). Xenobiotically induced metabolism, bioactivation and detoxification have also been studied (Parrish et al 1995; Price et al 1995; Price et al 1996; Lake et al 2003; De Kanter et al 2004; Price et al 2004; Harrigan et al 2006; Umachandran & Ioannides 2006; Pushparajah et al 2008; Hanlon et al 2009). Another interesting aspect of precision-cut lung slices is the use of tissue sections for infection studies.…”

Section: Short Review Of the History Of Precision-cut Lung Slicesmentioning

confidence: 99%

Assessment of immunotoxicity using precision-cut tissue slices

Sewald

Braun

2012

Xenobiotica

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1. When the immune system encounters incoming infectious agents, this generally leads to immunity. The evoked immune response is usually robust, but can be severely perturbed by potentially harmful environmental agents such as chemicals, pharmaceuticals and allergens.2. Immunosuppression, hypersensitivity and autoimmunity may occur due to changed immune activity. Evaluation of the immunotoxic potency of agents as part of risk assessment is currently established in vivo with animal models and in vitro with cell lines or primary cells.3. Although in vivo testing is usually the most relevant situation for many agents, more and more in vitro models are being developed for assessment of immunotoxicity. In this context, hypersensitivity and immunosuppression are considered to be a primary focus for developing in vitro methods. Three-dimensional organotypic tissue models are also part of current research in immunotoxicology.4. In recent years, there has been a revival of interest in organotypic tissue models. In the context of immunotoxicity testing, precision-cut lung slices in particular have been intensively studied. Therefore, this review is very much focused on pulmonary immunotoxicology. Respiratory hypersensitivity and inflammation are further highlighted aspects of this review. Immunotoxicity assessment currently is of limited use in other tissue models, which are therefore described only briefly within this review.

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Metabolism of [ring-U-14C] agaritine by precision-cut rat, mouse and human liver and lung slices

Cited by 10 publications

References 24 publications

In vitrolung slices: a powerful approach for assessment of lung pathophysiology

In vitrolung slices: a powerful approach for assessment of lung pathophysiology

Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

Assessment of immunotoxicity using precision-cut tissue slices

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