Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

Kondo, Kazunari; Watanabe, Asako; Iwanaga, Yuko; Abe, Ikuro; Tanaka, Hideya; Nagaoka, Megumi Hamano; Akiyama, Hiroshi; Maitani, Tamio

doi:10.1016/j.jchromb.2006.02.021

Cited by 11 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The [M − H] − ion at m / z 266.1146 for compound 7 was in accordance with the formula C 12 H 17 N 3 O 4 . This compound was tentatively identified as agaritine, a phenylhydrazine which is contained in large amount in cultivated Champignon . MS 2 experiments showed that the fragmentation pattern was in accordance with that reported by Janák et al .…”

Section: Resultssupporting

confidence: 85%

“…LC HRMS data of defatted alcoholic extracts from Pioppino (PM) and Champignon (CM) mushrooms Percentage of each identified compound based on peak areas contained in large amount in cultivated Champignon 59. MS 2 experiments showed that the fragmentation pattern was in accordance with that reported by Janák et al60 Compound 8 showed the [M − H] − ion at m/z 313.1140 (+1.2 ppm in PM, +0.1 in CM) and MS/MS fragment ions at m/z 181, 163, 149, 119, 113, 101 and 89.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Pioppino mushroom in southern Italy: an undervalued source of nutrients and bioactive compounds

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 85%

mentioning

confidence: 99%

Pioppino mushroom in southern Italy: an undervalued source of nutrients and bioactive compounds

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Hydrazines in general have also been found potent irreversible inactivators of some hemoproteins ( 101 ). Although the stability of the molecule was examined and that agaritine degrades within 48 h in tap water and that degradation appeared to be oxygen-dependent ( 102 ), the presence in plasma from agaritine-administration in mice or rats as its definite toxicity remains unclear ( 103 ). The concentration of agaritine in methanol extracts of food was 112–1836 µg g −1 dry weight, in a commercial product of ABM arrived at 1791 g g −1 dry weight and the calculated one-day intake of the product was estimated to be 8955 g according to the label ( 104 ).…”

Section: Toxicitymentioning

confidence: 99%

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco‐Toxicological Problems

Firenzuoli

Gori

Lombardo

2007

Evidence-Based Complementary and Alternative Medicine

223

195

View full text Add to dashboard Cite

Agaricus blazei Murrill (ABM) popularly known as 'Cogumelo do Sol' in Brazil, or 'Himematsutake' in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinarymedicinal biotechnological species. It was traditionally used to treat many common diseases like atherosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis and cancer. In vitro and in vivo ABM has shown immunomodulatory and antimutagenic properties, although the biological pathways and chemical substances involved in its pharmacological activities are still not clear. The polysaccharides phytocomplex is thought to be responsible for its immunostimulant and antitumor properties, probably through an opsonizing biochemical pathway. Clinical studies are positive confirmations, but we are still at the beginning, and there are perplexing concerns especially relative to the content of agaritine. Argantine is a well-known carcinogenic and toxic substance in animals, that must be completely and fully evaluated.

show abstract

“…This metabolite is particularly produced by species of Polysaccharides DOI 10.1007/978-3-319-03751-6_21-1 # Springer International Publishing Switzerland 2014 Agaricus when growth is ceased or any growing impediment is imposed (Kondo et al 2006). When such fungi are grown in culture conditions, these metabolites are introduced into the media.…”

Section: Preservation Of Fungal Materialsmentioning

confidence: 99%

Fungal Cultivation and Production of Polysaccharides

Camelini¹,

Rossi²,

Cardozo³

et al. 2014

Polysaccharides

View full text Add to dashboard Cite

Many species of higher basidiomycetes have traditionally been used because of their medicinal properties. The positive effects associated to the consumption of those fungi have been mainly attributed to cell wall polysaccharides, which have important structural roles and are present throughout the entire life cycles of fungi. One of the most consumed and studied species native of the Americas is Agaricus subrufescens, a mushroom prescribed in different countries for prophylaxis and noninvasive treatment of numerous health-related disorders. Prior to the process of extraction, purification, and application of these polysaccharides, one needs to be concerned with the preservation of the specimen and production of fungal biomass. Even though basidiomata (syn. fruiting bodies, mushrooms) generally yield larger volumes of biomass when compared to the mycelium, cultivation of mycelium allows a more efficient control of the process and, therefore, is the method of choice of polysaccharide production. Mycelial biomass can be produced by solid-state fermentation (SSF) or submersed fermentation (SmF). Further separation and concentration of bioactive polysaccharides can be done by means of porous membranes, such as tangential flow nanofiltration.

show abstract

Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography–tandem mass spectrometry

Cited by 11 publications

References 21 publications

Pioppino mushroom in southern Italy: an undervalued source of nutrients and bioactive compounds

Pioppino mushroom in southern Italy: an undervalued source of nutrients and bioactive compounds

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco‐Toxicological Problems

Fungal Cultivation and Production of Polysaccharides

Contact Info

Product

Resources

About