METABOLISM OF PROGESTERONE, 20α- AND 20β-Hydroxy-4-Pregnene-3-One IN UTERINE TISSUE OF OVARIECTOMIZED RATS

Holtermann, Merete Kile; Lisboa, B. P.

doi:10.1530/acta.0.080s105

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“…In laboratory animals the circulating levels of oestradiol also influence the uterine metabolism of oestradiol and progesterone in vivo and in vitro (Martin and Stone 1965;Pack and Brooks 1970;Armstrong and King 1971;Clark 1973;Saffron et al 1974;Holtermann and Lisboa 1975). In view of this the generally low level of metabolism of these two steroids, particularly to less active compounds, and the lack of influence of steroid treatment, in the present study, is rather surprising.…”

Section: Discussionmentioning

confidence: 49%

Oestradiol and Progesterone: Soluble Receptor Levels and Metabolism in the Uterus of the Ovariectomized Ewe

Murphy¹,

Stone²,

Miller³

et al. 1977

Aust. Jnl. Of Bio. Sci.

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Ovariectomized ewes received injections designed to mimic to some extent oestradiol and progesterone secretion during early pregnancy (maintenance progesterone), during oestrus (oestrous oestradiol) and during the luteal phase of the previous cycle (priming progesterone). The animals were killed at times equivalent to 1, 4 or 7 days after oestrus in those animals which had received oestrous oestradiol. The level of soluble oestradiol and progesterone receptors in whole uterus, and [3Hloestradiol and [3Hlprogesterone metabolism by uterus minces were measured.Oestradiol receptor level was highest on day 1 in those animals receiving oestrous oestradiol with no significant effect at any stage of the inclusion or omission of priming or maintenance progesterone. Progesterone receptor level was also high on day 1 in those animals receiving oestrous oestradiol with high levels maintained to day 4. Again, inclusion of priming or maintenance progesterone was without effect. In animals not receiving oestrous oestradiol the level of both receptors was uniformly low.Metabolism of [3Hloestradiol was low and not affected by treatment. [3HIProgesterone metabolism, although more variable, was also low and not affected by treatment.

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