1966
DOI: 10.1021/jf60147a028
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Metabolism of Naphthaleneacetic Acid-1-C14 in Rats

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1968
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Cited by 8 publications
(4 citation statements)
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“…However, the free acid is the main fecal metabolite and it seems likely that intestinal hydrolysis occurs prior to its absorption. Naphthaleneacetic acid is excreted in the bile as a glucuronide which has been postulated to undergo intestinal hydrolysis and absorption (56). Table I11 lists glucuronides which have been shown to be hydrolyzed and further metabolized in the intestine.…”
Section: Reactionsmentioning
confidence: 99%
“…However, the free acid is the main fecal metabolite and it seems likely that intestinal hydrolysis occurs prior to its absorption. Naphthaleneacetic acid is excreted in the bile as a glucuronide which has been postulated to undergo intestinal hydrolysis and absorption (56). Table I11 lists glucuronides which have been shown to be hydrolyzed and further metabolized in the intestine.…”
Section: Reactionsmentioning
confidence: 99%
“…Benzophenone oxime glucuronide was excreted not in feces but in urine. This result was supported by a number of investigations which reported that glucuronides were hydrolyzed by intestinal microorganisms of mammals and caused enterohepatic circulation (15,(20)(21)(22) to be excreted in urine.…”
Section: Resultsmentioning
confidence: 64%
“…Based on toxicological investigations on rats (Anderson et al, 1936;Lethco and Brouwer, 1966), mice (Holler et al, 1958), dogs (Bernhard and Caflisch-Weill, 1949), and chick embryos (Dye et al, 1944) an acceptable daily in- take of 1.5 mg of NAAamide or NAA per person per day can be tolerated (Schlatter, 1973). Therefore, an intake of 1 kg of apples per day containing 1.5 ppm of NAAamide or NAA would represent an upper toxicological limit for adult persons.…”
Section: Resultsmentioning
confidence: 99%
“…The detected amounts of NAAamide (0.049 ppm) and NAA (0.012 ppm) are far below this value. Since metabolic studies (Lethco and Brouwer, 1966) as well as carcinogenic investigations (Truhaut and Vermes, 1948;Innes et al, 1969) have shown no indication that NAAamide or NAA may pose health hazards, there appears to be no objection to the agricultural use of these two growth regulators.…”
Section: Resultsmentioning
confidence: 99%