Metabolism of monensin in the steer and rat

Donoho, Alvin L.; Manthey, John A.; Occolowitz, John L.; Zornes, Larry L.

doi:10.1021/jf60219a005

Cited by 76 publications

(64 citation statements)

References 3 publications

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“…Approximately 50 to 60% of the oral dose administered to cattle is metabolized and the remaining is eliminated in the parent form (Donoho et al 1978). The major metabolite of monensin is approximately 20 times less pharmaceutically active than the parent compound (Donoho 1984).…”

Section: Ionophoresmentioning

confidence: 99%

A Scoping Study of Livestock Antimicrobials in Agricultural Streams of Alberta

Forrest¹,

Lorenz²,

Thompson³

et al. 2011

Canadian Water Resources Journal

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Section: Ionophoresmentioning

confidence: 99%

A Scoping Study of Livestock Antimicrobials in Agricultural Streams of Alberta

Forrest¹,

Lorenz²,

Thompson³

et al. 2011

Canadian Water Resources Journal

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“…This paper examines the ESI-MS in-source CID fragmentation of alkali metal and ammonium ion adducts of monensins A, B, C and four known metabolites 21 of monensin, with the subsequent proposal of a rationale for the observed fragmentation of the [MNH 4 ] ions which may be applied to the confirmation and structural elucidation of both known and unknown monensin related compounds. Comparative structures of the compounds investigated are displayed in Fig.…”

Section: 2mentioning

confidence: 99%

Electrospray ionization mass spectrometry with in-source collision-induced dissociation of monensin factors and related metabolites

Kiehl

Julian

Kennington

1998

Rapid Commun. Mass Spectrom.

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Monensins are a series of polyether ionophore antibiotic factors produced by Streptomyces cinnamonensis. Three monensin factors and four metabolites of monensin A isolated from cattle feces were investigated by electrospray ionization mass spectrometry (ESI-MS). In-source collision-induced dissociation (CID) of the alkali metal and ammonium molecular ion adducts of monensin produce strikingly different mass spectra, with the alkali metal complexes exhibiting little dissociation and the ammoniated forms characterized by extensive fragmentation of the polyether skeletal structure with the production of several structurally diagnostic ions. The observed fragmentation of ammoniated monensin primarily involves opening of the cyclic ether rings and consecutive H 2 O losses. The propensity of ammoniated monensin derivatives toward skeletal fragmentation may involve the complexation of the thermally labile NH 4 ion through multiple hydrogen-bonding interactions with the polyether complexing oxygens resulting in decreased stability of the resultant complex. Comparison of the in-source CID spectra associated with the structurally similar compounds evaluated provides for the proposal of a general scheme for the fragmentation of ammoniated monensins and related compounds, the consistency of which indicates the usefulness of ESI-MS with insource CID in ionophore structure elucidation. # 1998 John Wiley & Sons, Ltd. Received 8 May 1998; Accepted 20 May 1998 Monensin is a polyether monocarboxylic acid ionophore and refers to a group of factors comprising an antibiotic complex first isolated from Streptomyces cinnamonensis.

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“…This explains why monensin was not detected in any of the edible tissues examined in this study. Monensin is known to be excreted rapidly in the urine and feces (Herberg and Van Duyn, 1969;Donoho et al, 1978).…”

Section: Resultsmentioning

confidence: 99%

Effect of High Levels of Monensin During the Growing Period on Subsequent Breeding Performance of Adult Broiler Breeders

Oyawoye

Krueger

1986

Poultry Science

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The breeding performance of broiler breeder chickens previously raised on high levels of monensin was evaluated. The birds were raised on concrete floors in an open-sided pullet brooding and growing house. At 21 weeks of age monensin feeding was stopped and birds were placed in the breeder house. A breeder ration formulated to contain 2,920 kcal metabolizable energy and 16% crude protein was fed to all the birds irrespective of the growing system used. A standard feeding allowance and lighting program as recommended by Indian River International was followed during the laying period. The parameters determined were body weight uniformity at 21 weeks of age, egg production, egg weight, shell weight, shell thickness, feed conversion (kilograms feed/dozen eggs), mortality, fertility, and hatchability. Assays for monensin residue in the breast muscle, liver, and abdominal fat were run at 52 weeks of age (31 weeks after monensin withdrawal). Birds grown on high levels of monensin were not as uniform in body weight at 21 weeks of age as the restricted controls. Only birds fed 400 ppm of monensin with a low protein diet during the growing period showed a significant reduction in egg production, shell weight, and shell thickness. There were no significant differences among the growing systems in mortality during lay, fertility, hatch of fertile eggs, and hatch of total eggs. Monensin was not detectable (less than .1 ppm) in the liver, abdominal fat, and breast muscle.(ABSTRACT TRUNCATED AT 250 WORDS)

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Metabolism of monensin in the steer and rat

Cited by 76 publications

References 3 publications

A Scoping Study of Livestock Antimicrobials in Agricultural Streams of Alberta

A Scoping Study of Livestock Antimicrobials in Agricultural Streams of Alberta

Electrospray ionization mass spectrometry with in-source collision-induced dissociation of monensin factors and related metabolites

Effect of High Levels of Monensin During the Growing Period on Subsequent Breeding Performance of Adult Broiler Breeders

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