Metabolism of Inorganic Fluoride

Smith, Frank A.

doi:10.1007/978-3-662-25198-0_2

Cited by 22 publications

(7 citation statements)

References 135 publications

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“…The plasma ,2 ,3 , 5 and calcified tissue6 7,8 ionic fluoride concentrations in experimental animals and human subjects have generally been found to reflect fluoride intake. These concentrations, however, are not related to intake in a simple linear fashion and, further, most reports indicate considerable individual variation in these concentrations.3,'56'9 These findings suggest that fluoride balance or retention is variable, not only among individuals or groups but also within individuals, over time.…”

Section: Introductionmentioning

confidence: 98%

Plasma and Developing Enamel Fluoride Concentrations During Chronic Acid-base Disturbances

Whitford

Reynolds

1979

J Dent Res

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Mild acid-base disturbances were induced in rats for 30 days. These disturbances did not affect % ash of maxillary incisors or % P of the developing enamel from mandibular incisors. Total fluoride intake (food and water) among groups drinking fluoride-free water was constant. Nevertheless, average plasma and developing enamel fluroide concentrations were highest in the acidotic group and lowest in the alkalotic group. Among groups drinking water containing 50 ppm fluoride, total fluoride intake was highest by the alkalotic group and lowest by the acidotic group. Plasma and enamel fluoride concentrations, however, were highest in the acidotic group. It is concluded that plasma and developing enamel fluoride levels can be independent of, or inversely related to, fluoride intake.

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Section: Introductionmentioning

confidence: 98%

Plasma and Developing Enamel Fluoride Concentrations During Chronic Acid-base Disturbances

Whitford

Reynolds

1979

J Dent Res

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“…Urine Sr, Pb, F. These elements were assayed because they reside principally in the skeleton and are known as bone seekers [32]. During the control periods (the subjects being given distilled water), the average daily excretion of stable Sr among these subjects (Table II).…”

Section: Resultsmentioning

confidence: 99%

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

et al. 1972

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ExtractThe effect of human growth hormone (GH) administration (5 mg daily) was studied in 12 children with short stature, in an attempt to elucidate the cause of the hypercalcuria which so commonly occurs at the initiation of GH therapy. Complete metabolic balances were determined for Ca, P, N, Na, K, and Cl; and urine was analyzed for hydroxyproline, stable Sr, Pb, Mg, 137 Cs, F, and creatinine. Some subjects had determinations of basal metabolic rate (BMR) and of ultrafiltrable serum Ca. In keeping with the reports of others, levels of N, P, K, Na, and Cl in urine all declined, as did that of 187 Cs; Mg excretion fell slightly. Ten of the 12 children with short stature (6 of whom had subnormal plasma GH responses to a variety of stimuli) had hypercalcuria; 3 of these had an increase in urine Ca in the face of a low Ca diet (170 mg/24 hr). Fecal Ca declined in some subjects and rose in others. Ultrafiltrable serum Ca did not change.A majority of the subjects showed an increase in the urinary excretion of F, Sr, Pb, and hydroxyproline.The effect of the hormone was also studied in three patients with idiopathic hypoparathyroidism; two of these responded with an increase in urine Ca.The magnitude of the rise in urine Ca could not be correlated with changes in BMR, changes in creatinine clearance, or changes in Na excretion; it was positively correlated with the increases in Sr and Pb in urine. SpeculationWe have evidence that the hypercalcuria accompanying GH administration is not due to increased gastrointestinal absorption, alterations in serum Ca, or changes in metabolic rate or renal function; nor is it mediated via parathyroid activity. These considations, plus the fact that the hypercalcuria is accompanied by hydroxyprolinuria and an increase in the urinary excretion of three "bone seekers" (Sr, Pb, and F), lead us to postulate that the hormone enhances bone resorption, either per se or via "sulfation factor."

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“…As chyme passes into the duodenum, cal cium fluoride may reprecipitate on mixing with the alkaline pancreatic juice because of the reconversion of HF to F", and be poorly absorbed. However, several studies have suggested that fluoride is absorbed from the stomach [Smith, 1966; and this important aspect of fluoride metab olism should be clarified by further re search.…”

Section: Discussion By C Dawes and G M Whitford1mentioning

confidence: 99%

Biochemistry of Fluoride in Saliva

Il¹

1977

Caries Res

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Metabolism of Inorganic Fluoride

Cited by 22 publications

References 135 publications

Plasma and Developing Enamel Fluoride Concentrations During Chronic Acid-base Disturbances

Plasma and Developing Enamel Fluoride Concentrations During Chronic Acid-base Disturbances

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

Biochemistry of Fluoride in Saliva

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