Biochemistry of Fluoride in Saliva

Il, Shannon

doi:10.1159/000260301

Cited by 14 publications

(5 citation statements)

References 26 publications

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“…The intake of either 1 or 2.5 mg fluoride with milk did not result in significant changes in the fluoride concentration of LGS. It is known that fluoride ion moves into saliva by a passive glandular mechanism and the increase of fluoride concentration of unstimulated saliva results not from the movement of fluoride but from the water removal from the luminal fluid [Shannon, 1977]. Data on fluoride secretion by the minor salivary glands are lacking.…”

Section: Discussionmentioning

confidence: 99%

Fluoride Concentrations of Unstimulated Whole and Labial Gland Saliva in Young Adults after Fluoride Intake with Milk

2001

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Following a fluoride depletion period 6 subjects repeatedly rinsed with 30–ml volumes of milk with or without added fluoride (5 ppm). Rinsing time was timed according to the measurements on how long it took to drink 200 or 500 ml milk. Rinsing with fluoridated milk for a total interval of 20 and 60 s, respectively, did not influence significantly the fluoride concentration of unstimulated centrifuged whole saliva 45 min later. Neither the urinary fluoride concentration nor the fluoride excretion were significantly affected by rinsing with fluoridated milk during the first hour. However, intake of 1 or 2.5 mg of fluoride with 200 and 500 ml milk, respectively, resulted in significant elevations in whole saliva fluoride levels 45 min later. In addition, the fluoride excretions into urine produced during 60 min after the fluoride intakes were significantly elevated and those reflected the ingested dose of fluoride. The intake of either 1 or 2.5mg fluoride with milk did not significantly influence the fluoride level of unstimulated labial gland saliva collected simultaneously with whole saliva.

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Section: Discussionmentioning

confidence: 99%

Fluoride Concentrations of Unstimulated Whole and Labial Gland Saliva in Young Adults after Fluoride Intake with Milk

2001

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“…Only when the oral fluids become unsaturated with respect to the apatites, e.g., caused by a pH drop, may a change of the apatite composition occur. The fluoride concentration in oral fluids is around 0.02 ppm (Jenkins and Edgar, 1977;Shannon, 1977), and saliva is therefore unsaturated with respect to calcium fluoride; thus, this salt dissolves whenever it is exposed to saliva.…”

Section: The Effect Of Fluoride On Erupted Teethmentioning

confidence: 99%

Dental Tissue Effects of Fluoride

Fejerskov¹,

Larsen²,

Richards³

et al. 1994

Adv Dent Res.

204

149

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It is now well-established that a linear relationship exists between fluoride dose and enamel fluorosis in human populations. With increasing severity, the subsurface enamel all along the tooth becomes increasingly porous (hypomineralized), and the lesion extends toward the inner enamel. In dentin, hypomineralization results in an enhancement of the incremental lines. After eruption, the more severe forms are subject to extensive mechanical breakdown of the surface. The continuum of fluoride-induced changes can best be classified by the TF index, which reflects, on an ordinal scale, the histopathological features and increases in enamel fluoride concentrations. Human and animal studies have shown that it is possible to develop dental fluorosis by exposure during enamel maturation alone. It is less apparent whether an effect of fluoride on the stage of enamel matrix secretion, alone, is able to produce changes in enamel similar to those described as dental fluorosis in man. The clinical concept of post-eruptive maturation of erupting sound human enamel, resulting in fluoride uptake, most likely reflects subclinical caries. Incorporation of fluoride into enamel is principally possible only as a result of concomitant enamel dissolution (caries lesion development). At higher fluoride concentrations, calcium-fluoride-like material may form, although the formation, identification, and dissolution of this compound are far from resolved. It is concluded that dental fluorosis is a sensitive way of recording past fluoride exposure because, so far, no other agent or condition in man is known to create changes within the dentition similar to those induced by fluoride. Since the predominant cariostatic effect of fluoride is not due to its uptake by the enamel during tooth development, it is possible to obtain extensive caries reductions without a concomitant risk of dental fluorosis.

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“…The salivary fluoride concentration is independent of salivary flow rate (Shannon et aL, 1973;Shannon, 1977;Oliveby et aL, 1989a,b,c). Ingested fluoride doses of 3,5, and 10 mg increase the fluoride concentration to a peak level in parotid saliva within 30-40 min after fluoride intake (Shannon and Edmonds, 1972).…”

Section: Fluoridementioning

confidence: 99%

Caries-Protective Factors in Saliva

Lagerlöf

1994

Adv Dent Res.

102

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Saliva influences caries attack mainly by its rate of flow and by its content of fluoride. The salivary flow rate influences to a high degree the rate of oral and salivary clearance of bacterial substrates included in foods and snacks. This influence is site-dependent. The basal salivary fluoride concentration is low, about 1 mumol/L, independent of salivary flow rate, and not influenced by diurnal variation. After an exposure of the oral cavity to fluoride, the increased fluoride level is decreased by a process influenced mainly by the salivary flow rate and the volumes of saliva in the mouth before and after swallowing. Other less important caries-protective factors in saliva include its buffer ability, its content of calcium, inorganic phosphate, pH-increasing substances, and anti-microbial agents.

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Biochemistry of Fluoride in Saliva

Cited by 14 publications

References 26 publications

Fluoride Concentrations of Unstimulated Whole and Labial Gland Saliva in Young Adults after Fluoride Intake with Milk

Fluoride Concentrations of Unstimulated Whole and Labial Gland Saliva in Young Adults after Fluoride Intake with Milk

Dental Tissue Effects of Fluoride

Caries-Protective Factors in Saliva

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