Metabolism of Human Gamma Macroglobulins*

Barth, Werner F.; Wochner, R. Dean; Waldmann, Thomas A.; Fahey, John L.

doi:10.1172/jci104987

Cited by 184 publications

(77 citation statements)

References 26 publications

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“…LDL has several singular metabolic features when compared with other plasma proteins. To begin with, although LDL is similar to other large serum proteins such as IgM and fibrinogen with regard to its distribution among the body compartments, the fractional catabolic rate of LDL is significantly greater than these proteins (25,26). This suggests that LDL may be acted upon by a unique catabolic mechanism not shared by other proteins, or more likely, that LDL is subject to a specific degradation mechanism which acts in addition to a more generalized catabolic mechanism.…”

Section: Discussionmentioning

confidence: 99%

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia

Langer¹,

Strober²,

Levy³

1972

J. Clin. Invest.

616

182

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A B S T R A C T The metabolism of low density lipoprotein (LDL, beta lipoprotein) was studied in 10 normal individuals and 10 patients with familial type II hyperlipoproteinemia using purified radioiodinated LDL. Over 97% of the label was bound to the protein moiety of LDL and therefore the turnover data reflect the fate and distribution of LDL-apoprotein. Comparison of the metabolic behavior of biologically screened and utnscreened labeled LDL preparations in dogs as well as the analysis of the urinary excretion of radioiodide derived from labeled LDL degradation in humans indicated that no significant denaturation resulted from the isolation, purification, and labeling techniques.The plasma concentration of LDL-cholesterol in nor-.mals was 105±21 mg/100 ml (mean +1 SD) in contrast to 254±47 mg/100 mg in patients with type II hyperlipoproteinemia; these values corresponded to LDL-apoprotein concentrations of 63±13 mg/100 ml and 153±(30 mg/100 ml, respectively. Despite these differences in concentration, the synthetic rate of LDL-apoprotein in both groups was not significantly different (14

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Section: Discussionmentioning

confidence: 99%

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia

Langer¹,

Strober²,

Levy³

1972

J. Clin. Invest.

616

182

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“…In 1956 Zinneman and Rotstein reported decreased y-globulins in 7 of 12 patients with myotonic dystrophy (6). It was found that the survival halftime of 1311-labeled y-globulin in six of these patients averaged 7.6 days compared to 10.5 days in controls, whereas the survival of albumin-'31I averaged 10.2 days compared to 9.6 days in controls.…”

mentioning

confidence: 83%

“…However, in each instance studied, the basic disorder has been that of defective synthesis, with normal or prolonged survival of the affected proteins. Normal survival has been observed for fibrinogen in afibrinogenemia (23), ceruloplasmin in Wilson's disease (24), and IgM and IgA in agammaglobulinemia (10,25). The survival of albumin in analbuminemia (26)(27)(28) and IgG in agammaglobulinemia (16) (29,30) and by the newborn gut in certain species (31) (32), liver disease (33), and multiple myeloma (9, 34), or after infusion of IgG (35,36).…”

Section: Methodsmentioning

confidence: 99%

Accelerated breakdown of immunoglobulin G (IgG) in myotonic dystrophy: a hereditary error of immunoglobulin catabolism.

Wochner¹,

Drews²,

Strober³

et al. 1966

J. Clin. Invest.

153

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“…The serum level of 7S 7-globulin (IgG) helps to determine the catabolic rate; the higher the serum level, the greater the catabolic rate (5,6). 18S 71-macroglobulin (IgM) catabolism, however, appears to be unrelated to the serum 71-macroglobulin level (2). Thus the catabolic properties of all classes of immunoglobulins need to be characterized and the catabolic interrelationships between immunoglobulin classes further defined.…”

mentioning

confidence: 99%

The Immunoglobulins of Mice

Fahey

Sell

1965

The Journal of Experimental Medicine

Self Cite

147

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Antibodies of all species are present in several classes of immunoglobulin. The serum level of each immunoglobulin class is determined by its rate of synthesis and catabolism. Thus catabolic properties are important biologic features of antibody because of the importance of catabolism in regulating serum level and in determining the survival of an antibody molecule.Studies in man (1, 2), rabbit (3), and guinea pig (4) have shown that the 18S 71-macroglobu]ins (IgM) are catabolized much more rapidly than 7S 72-globulins (IgG). Thus, immunoglobulin classes may differ in their rates of turnover. Differences in the catabolic control of immunoglobulins are also discernable. The serum level of 7S 7-globulin (IgG) helps to determine the catabolic rate; the higher the serum level, the greater the catabolic rate (5, 6). 18S 71-macroglobulin (IgM) catabolism, however, appears to be unrelated to the serum 71-macroglobulin level (2). Thus the catabolic properties of all classes of immunoglobulins need to be characterized and the catabolic interrelationships between immunoglobulin classes further defined.Four major classes of immunoglobulins, the 7S 7~-globulins, the 7S 71-globulins, the 71A (/32A, IgA)-globulins and 71M (IgM)-macroglobulins have been identified in recent studies in mice (7). These components are seen on immunoelectrophoresis of hyperimmune serum in Fig. 1. In addition, two subclasses of 7S 72-globulin have been identified and tentatively designated as 72a-and 72b-globulins (8). These findings provided an opportunity to investigate further the catabolic relationship between different classes of immunoglobulin. In no species has the metabolism of five classes of immunoglobulin been compared. The present investigation was undertaken to compare the rate of catabolism of 72,-, 7~b-, and 7S 71-globulins, 7~A (/32A)-globulins, and 71-macroglobulins in mice. Investigations were carried out in mice with low, normal, or high levels of all immunoglobulins, as well as in mice with selective immunoglobulin increases produced by plasma cell tumors. 41 on

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Metabolism of Human Gamma Macroglobulins*

Cited by 184 publications

References 26 publications

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia

Accelerated breakdown of immunoglobulin G (IgG) in myotonic dystrophy: a hereditary error of immunoglobulin catabolism.

The Immunoglobulins of Mice

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