Metabolism of Ginseng and its Interactions with Drugs

Qi, Lian‐Wen; Wang, Chong‐Zhi; Du, Guang-Jian; Zhang, Zhiyu; Calway, Tyler; Yuan, Chun‐Su

doi:10.2174/138920011797470128

Cited by 96 publications

(71 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are also many reports that ginseng has antiaging and antioxidant properties (8). The various pharmacological and biological effects of ginseng are mainly mediated by compounds from the saponin group, called ginsenosides (9). Accumulating evidence has revealed that the major functional components of ginsenoside have antiinflammatory, antidiabetic and antitumor effects (10,11).…”

Section: Introductionmentioning

confidence: 99%

The ginsenoside metabolite compound K inhibits growth, migration and stemness of glioblastoma cells

Lee

Kwon

Jang

et al. 2017

International Journal of Oncology

View full text Add to dashboard Cite

Glioblastoma (GBM) is the most aggressive and malignant form of primary brain cancer. Despite recent advances in cancer treatment, it remains a substantially incurable disease. Accordingly, more effective GBM therapeutic options are urgently required. In the present study, we investigated the anticancer effect of a ginsenoside metabolite, compound K (CK), against GBM cells. CK significantly inhibited not only growth, but also metastatic ability of U87MG and U373MG cells. CK arrested cell cycle progression at the G0/G1 phase with a decrease in the expression levels of cyclin D1 and cyclin D3 in both cell types. CK also induced apoptosis in GBM cells through nuclear condensation, an increase in ROS generation, mitochondrial membrane potential depolarization, and activation of caspase-3, caspase-9 and poly(ADP-ribose) polymerase (PARP). Furthermore, CK inhibited phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway, contributing to the antiproliferative and apoptotic effects. Moreover, CK suppressed the self-renewal capacity as well as the invasiveness of U87MG and U373MG GBM stem-like cells (GSCs) by inducing a reduction in the expression of GSC markers, such as CD133, Nanog, Oct4 and Sox2. Taken together, our findings suggest that CK may potentially be useful for GBM treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

The ginsenoside metabolite compound K inhibits growth, migration and stemness of glioblastoma cells

Lee

Kwon

Jang

et al. 2017

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…Although numerous reviews on ginseng-drug interaction have been already published [47, 48], no article has critically reviewed ginseng-anticancer drug combination for improvement of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review

Chen

Wang

Huang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Ginseng, a well-known herb, is often used in combination with anticancer drugs to enhance chemotherapy. Its wide usage as well as many documentations are often cited to support its clinical benefit of such combination therapy. However the literature based on objective evidence to make such recommendation is still lacking. The present review critically evaluated relevant studies reported in English and Chinese literature on such combination. Based on our review, we found good evidence from in vitro and in vivo animal studies showing enhanced antitumor effect when ginseng is used in combination with some anticancer drugs. However, there is insufficient clinical evidence of such benefit as very few clinical studies are available. Future research should focus on clinically relevant studies of such combination to validate the utility of ginseng in cancer.

show abstract

“…Its bioavailability is low. Gut microbial flora is responsible for the production of different metabolites such as ginsenosides, polysaccharides, peptides, and gintonins [22,23] . However, because of poor membrane permeability and low solubility, absorption of these products is limited.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Korean Red Ginseng on Cisplatin Ototoxicity: Is It Effective Enough?

Olgun¹,

Kırkım²,

Altun³

et al. 2016

Int Adv Otol

View full text Add to dashboard Cite

1 (HEI-OC1) cell line. Cells were treated with CDDP, KRG, and their combination for 24 h. Cell viability, apoptosis, and the expression of 84 apoptosis-related genes were analyzed. In the second part of the study, 30 Wistar albino rats were divided into five groups. Baseline distortion product otoacoustic emissions (DPOAEs) and auditory brainstem response (ABR) measurements were obtained. In groups I, II, and III, only saline, KRG, and CDDP, respectively, were given. In group IV, 500 mg/kg KRG and in group V, 150 mg/kg of KRG were administered for 10 days. In groups III, IV, and V, 16 mg/kg CDDP injections were administered on day 11. On day 14, final DPOAEs and ABR measurements were completed. The rats were then sacrificed, and their inner ear structures were evaluated by transmission electron microscopy. RESULTS:In the first part of the study, pretreatment with 1 mg/mL KRG protected cells from CDDP ototoxicity. This protection was mainly due to a decline in apoptotic gene expression and an increase in antiapoptotic gene expression. In the in vivo part of the study, we found that both KRG doses had otoprotective effects. This protection was more prominent at the lower dose, especially on the spiral ganglion and the brainstem.CONCLUSION: KRG was shown to be an otoprotective agent against CDDP-induced ototoxicity both in vivo and in vitro.

show abstract

Metabolism of Ginseng and its Interactions with Drugs

Cited by 96 publications

References 57 publications

The ginsenoside metabolite compound K inhibits growth, migration and stemness of glioblastoma cells

The ginsenoside metabolite compound K inhibits growth, migration and stemness of glioblastoma cells

Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review

Protective Effect of Korean Red Ginseng on Cisplatin Ototoxicity: Is It Effective Enough?

Contact Info

Product

Resources

About