Protective Effect of Korean Red Ginseng on Cisplatin Ototoxicity: Is It Effective Enough?

Olgun, Yüksel; Kırkım, Günay; Altun, Zekiye; Aktaş, Safiye; Kolatan, Efsun; Kıray, Müge; Bağrıyanık, Alper; Olgun, Aybüke; Kızmazoğlu, Deniz; Özoğul, Candan; Ellıdokuz, Hülya; Erçetin, Pınar; Serbetcioglu, Bulent; Yılmaz, Osman; Günerı, Enis Alpin

doi:10.5152/iao.2016.1989

Cited by 14 publications

(10 citation statements)

References 24 publications

(51 reference statements)

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“…Oshima et al (19) evaluated morphological changes on the surface of corti organ through fluorescence microscopy in their study in which they examined the ototoxicity of daptomycin in guinea pigs. Olgun et al (20) evaluated the spiral ganglion and corti organ surface morphology using electron microscopy in their study in which they detected the protective effects of red ginseng against the ototoxicity of cisplatin. In our study, we used SEM to show ototoxicity-related outer hair cell damage.…”

Section: Discussionmentioning

confidence: 99%

Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study

Abaylı

Kul

Koten

et al. 2017

Turk Arch Otorhinolaryngol

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Objective: This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations. Methods:Electrophysiological assessment was performed with tympanometry, auditory brainstem response (ABR), and distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 40 ears of 20 guinea pigs that were detected to have normal hearing thresholds. The animals were randomly assigned to three groups: Group 1 (n=12) received 0.1 mL rifamycin, Group 2 (n=8) received 0.1 ml gentamycin, and Group 3 (n=20) received 0.1 mL physiological saline. The antibiotics and saline solutions were administered via intratympanic injections. After five injections every other day, electrophysiological tests were performed again on the 15th day. After electrophysiological measurements, the temporal bones of all guinea pigs were prepared for ultrastructural examinations and the cochlear surface morphology was examined by scanning electron microscopy (SEM). Results:The animals in group 3 did not show a statistically significant change in their DPOAE signal/noise ratio (SNR) or ABR thresholds (p>0.05). In groups 1 and 2, the reduction in the DPOAE SNR and the increase in the ABR threshold were statistically significant (p<0.05). Regarding SEM examination results, the animals in groups 1 and 2 showed statistically significant outer hair cell damage and cochlear degeneration due to the ototoxic effect of the drugs (p<0.05), whereas the animals in group 3 showed no significant damage (p>0.05). Conclusion:The results indicate that rifamycin application to the middle ears of guinea pigs has mild ototoxic effects on their inner ears.

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Section: Discussionmentioning

confidence: 99%

Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study

Abaylı

Kul

Koten

et al. 2017

Turk Arch Otorhinolaryngol

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“…186 In several animal models, ginseng protected animals from cisplatin nephrotoxicity and ototoxicity. [187][188][189][190][191][192] Ginseng in rats reduced cisplatininduced nausea and weight loss. 193,194 632…”

Section: Cancermentioning

confidence: 97%

Ginseng: A Qualitative Review of Benefits for Palliative Clinicians

Davis

Behm

2019

Am J Hosp Palliat Care

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Ginseng has been used for centuries to treat various diseases and has been commercially developed and cultivated in the past 300 years. Ginseng products may be fresh, dried (white), or dried and steamed (red). Extracts may be made using water or alcohol. There are over 50 different ginsenosides identified by chromatography. We did an informal systematic qualitative review that centered on fatigue, cancer, dementia, respiratory diseases, and heart failure, and we review 113 studies in 6 tables. There are multiple potential benefits to ginseng in cancer. Ginseng, in certain circumstances, has been shown to improve dementia, chronic obstructive pulmonary disease, and heart failure through randomized trials. Most trials had biases or unknown biases and so most evidence is of low quality. We review the gaps in the evidence and make some recommendations regarding future studies.

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“…There are strong nucleophilic compounds containing sulfur that have the ability to enter interactions with the electrophilic structure of platinum linked to large density of electrons around the sulfur atoms. Amifostine, WR-1065, N-acetyl cysteine, acetyl-l-carnitine, dmethionine, sodium thiosulfate and erdostein thio are among these protective agents as they form complexes with cisplatin due to structure (Altun et al 2014, Altun et al 2016, Altun et al 2010, Gunes et al 2011, Olgun et al 2013, Tufekci et al 2009) (Altun et al 2014, Altun et al 2016, Altun et al 2010, Doğan et al 2014, Gunes et al 2011, Olgun et al 2013, Olgun et al 2016b, Tufekci et al 2009. As ROS formation is the most important factor starting ototoxicity, strategies to prevent ototoxicity include administering free radical scavengers (amifostine, acetyl cysteine, salicylate and vitamin E) to prevent ROS reactions with cellular protein, lipid and DNA.…”

Section: Apoptotic Mechanism Of Cisplatin Toxicitymentioning

confidence: 99%

Cytotoxic and Molecular Mechanisms in Ototoxicity of Cisplatin

2018

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Ototoxicity is based on inner ear dysfunction creating hearing loss, balance disorder or both symptoms depending on the drug or chemical agent. Genetic and nongenetic risk factors, in addition to dose and time, play important roles in cisplatin ototoxicity. Although the changes firstly begin from first line of outer hairy cells on the Corti organ in the inner ear and then progress. Though the effect on the spiral ganglion and stria vascularis in addition to the Corti organ are welldefined, the molecular mechanisms that cause hearing loss are not fully understood. Cellular and molecular mechanisms and particularly apoptotic mechanisms explain cisplatin cytotoxicity leading to cochlea damage. DNA damage induced by cisplatin and ROS production seem to be mainly responsible for cisplatin toxicity. Children treated with cisplatin are at risk of early or late hearing loss which could affect learning, communication, school performance, social communication and general quality of life. For this reason, many protective agents are used with cisplatin without changing its antitumoral efficiency. Studies of compounds to prevent ototoxicity may provide compounds for use in routine clinical practice and prevent one of the major dose-limiting side effects of cisplatin therapy, which will increase treatment efficacy and improve patient quality of life.

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Protective Effect of Korean Red Ginseng on Cisplatin Ototoxicity: Is It Effective Enough?

Cited by 14 publications

References 24 publications

Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study

Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study

Ginseng: A Qualitative Review of Benefits for Palliative Clinicians

Cytotoxic and Molecular Mechanisms in Ototoxicity of Cisplatin

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