METABOLISM IN THE RAT OF THREE AMINO ACIDS LACKING Α-Hydrogen

Christensen, Halvor N.; Aspen, Anita J.; Rice, Edward G.

doi:10.1016/s0021-9258(18)65352-9

Cited by 64 publications

(3 citation statements)

References 17 publications

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“…period of the experiment. Christensen et al (1956) found that at 5 hr. after injection the concentration of oc-aminoisobutyric 1-80, 2-12, 2-38, 2-93 6-1, 7-0, 5-6 6-2 8-9, 7-2, 7-3, 9-6 8-3, 5-4, 6-8, 12, 7-5, 7-7 11 12-9 15-2, 10-2, 12-2 15-5, 12 7-4, 9-6, 8-6, 2-2, 2-5, 2*3, 3-2 5-1, 4-0 7.7, 10.9, 8-3, 6-0 3 0, 259, 1-3, 1-5 8-3, 5-7, 7-4, 3-5 acid was not falling rapidly in the serum, and the distribution ratio had reached a maximum in the liver.…”

Section: Resultsmentioning

confidence: 99%

“…In the present work, the connexion between growth of the rat uterus during pregnancy and the concentration of free amino acids in the tissue has been studied, as well as the power of the pregnant uterus at different stages to accumulate free amino acids. The latter question has been studied by means of the unnatural amino acid, oc-amino[14C]isobutyric acid, which cannot disappear through metabolism in the tissue (Christensen, Aspen & Rice, 1956). Some experiments on the uptake of [14C]ornithine, a natural amino acid believed not to be incorporated into protein, were also made, as in the work of Manchester & Young (1960) on the effect of insulin on amino acid accumulation in the diaphragm.…”

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confidence: 99%

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Amino acids and growth of the pregnant uterus

Williams¹,

Needham²

1964

Biochemical Journal

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Amino acids and growth of the pregnant uterus

Williams¹,

Needham²

1964

Biochemical Journal

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“…Acronycine (1), also known as acronine, one of a group of alkaloids isolated from the bark of an Australian tree, has been shown to have broad spectrum antitumor activity against experimental neoplasms in laboratory animals. 1 Acronycine, possessing an acridone system fused to a gemdimethyldihydropyran ring, is unique among cancer chemotherapeutic agents. It represents a new lead in chemotherapy.…”

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confidence: 99%

Preparation and antitumor properties of analogs of acronycine

Liska¹

1972

J. Med. Chem.

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Nutrient effects on microbial transformation of pesticides in nitrifying surface waters

Vink¹,

Schraa

Zee³

1999

Environ. Toxicol.

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Multivariate analyses of a large set of physical, chemical, and biological measurements indicated possible effects that specific surface water properties have on biotransformation rates of pesticides. In this study, we investigated the roles of Mg, Mn, and P, which were identified as relevant, discriminating environmental variables in the overall biotransformation process as it occurred under nitrifying conditions. Nematicide aldicarb, herbicides simazine and MCPA were selected as their chemical group representatives. Series of mechanically aerated incubation vessels were set up to test nutrient enrichment effects on microbial development and subsequent pesticide transformation. Accounting for alterations in system conditions, relevant (physico)chemical characteristics were monitored. An increase in total microbial population was observed in surface water samples in the presence of both aldicarb and simazine. No increase was observed when MCPA was added, which was probably cometabolized. Large phosphorus concentrations not only favored bacterial growth, but also increased the residence time of dissolved Mn which under certain conditions promoted biotransformation. Furthermore, PO4 enrichment decreases aldicarb's aerobic metabolites' concentrations. Simazine was persistent over a period of at least 80 days, except for a short period coinciding with the nitrification period in which NH 4+ dissipates and NO2 and NO 3− are formed. Selective bacterial growth was observed on simazine's transformation product DES. Relationships of Mg/Mn concentrations to MCPA transformation rates, and of PO4/PT concentrations to aldicarb transformation rates, are presented. These relationships are assessed as environmental indicators for potential biotransformation, but only under conditions warranting development and growth of a degrading population over a prolonged period. ©1999 John Wiley & Sons, Inc. Environ Toxicol 14: 329–338, 1999

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METABOLISM IN THE RAT OF THREE AMINO ACIDS LACKING Α-Hydrogen

Cited by 64 publications

References 17 publications

Amino acids and growth of the pregnant uterus

Amino acids and growth of the pregnant uterus

Preparation and antitumor properties of analogs of acronycine

Nutrient effects on microbial transformation of pesticides in nitrifying surface waters

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