Metabolism in Idiopathic Steatorrhea. I. The Influence of Dietary and Other Factors on Lipid and Mineral Balance

Bassett, Samuel H.; Keutmann, E. Henry; Hyde, Henry Van Zile; Alstine, Helen E. Van; Russ, Ella M.

doi:10.1172/jci101012

Cited by 33 publications

(11 citation statements)

References 16 publications

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“…This report supplements a previous paper (8) and deals specifically with (a) the effect of parenterally administered liver extract on lipid and mineral balances, (b) the effect of diet and other therapeutic procedures on the level of calcium and inorganic phosphorus in the serum, and (c) the effect of administration of vitamin D concen-trates.…”

mentioning

confidence: 54%

“…The fourth patient, S. B., received liver therapy while on the general ward and since dietary control was inadequate balances could not be kept. The impressions gained in his case have been summarized in his case report (8). Lilly's liver extract (concentrate, N.N.R.)'…”

Section: Presentation Of Datamentioning

confidence: 97%

“…The four patients whose case histories have been given in detail elsewhere (8) all received parenteral liver extract and a vitamin D concentrate during some period of the investigation. The diets and methods of investigation were the same as those used previously (8).…”

Section: Presentation Of Datamentioning

confidence: 99%

“…Patient S. B., on the other hand, has shown a definite tendency to develop hypocalcemia and hypophosphatemia when his food was no longer fortified with viosterol. The time interval involved is not known accurately, but relapse has occurred in less than eleven months (see Case report (8)). Direct Our experience with liver extract in treatment of two patients, one of whom had hypochromic anemia and mild steatorrhea, the other a very mild macrocytic anemia and severe steatorrhea did not point to a specific action of the extract on the fatty diarrhea.…”

Section: Presentation Of Datamentioning

confidence: 99%

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Metabolism in Idiopathic Steatorrhea. Ii. Effect of Liver Extract and Vitamin D on Calcium, Phosphorus, Nitrogen, and Lipid Balances

Bassett¹,

Keutmann²,

Hyde³

et al. 1939

J. Clin. Invest.

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Amelioration of the symptoms of tropical sprue, particularly the anemia and gastro-intestinal disturbances, has followed the oral and parenteral administration of liver or liver extracts (1,2,3,4). It has been claimed that similar treatment is effective in the treatment of idiopathic steatorrhea (non-tropical sprue) (5). Barker and Rhoads (6), in a study of the blood lipids in sprue, came to the conclusion that liver extract must exert some specific effect on intestinal absorption. The plasma lipids of the treated cases increased after a meal containing fat, while those patients, who received only a sprue diet, failed to show a similar increase during the test. Ross (7), on the other hand, in an investigation of celiac disease (a condition perhaps identical with idiopathic steatorrhea) was unable to demonstrate any effect on the absorption of carbohydrate after injections of liver extract (campolon). He believed that this form of treatment improved the utilization of intravenous glucose.Whether identical metabolic defects exist in these three diseases is still an open question. It, therefore, seems pertinent to describe the results of balance studies of patients undergoing treatment with liver extract, who have never resided in the tropics and yet have presented the syndrome of sprue. The term idiopathic steatorrhea as used in this connection has been considered synonymous with non-tropical sprue.

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confidence: 54%

Section: Presentation Of Datamentioning

confidence: 97%

Section: Presentation Of Datamentioning

confidence: 99%

Section: Presentation Of Datamentioning

confidence: 99%

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Metabolism in Idiopathic Steatorrhea. Ii. Effect of Liver Extract and Vitamin D on Calcium, Phosphorus, Nitrogen, and Lipid Balances

Bassett¹,

Keutmann²,

Hyde³

et al. 1939

J. Clin. Invest.

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“…reported by Bassett et al (1939). On the other hand, the results show that once vitamin D was made available the excess of fat in the facces did not prevent calcium absorption by soap formation.…”

Section: Absorption Of Vitamin D In Steatrrhea Mical Journalmentioning

confidence: 69%