Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration

McKenna, Michael J.; Zempel, J.A.; Madrid, E.O.; Braun, Werner; Gehring, P.J.

doi:10.1016/0041-008x(78)90173-4

Cited by 60 publications

(17 citation statements)

References 8 publications

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“…This is in contrast to experiments where dichloroethylene was administered in corn oil, in which peak concentrations in exhaled air were observed in 30 to 60 minutes (McKenna et al, 1978), and for tetrachloroethylene in corn oil, which yielded a peak blood concentration in 60 minutes (Pegg et al, 1979). Dosing of humans with chloroform in olive oil (Fry et al, 1972) also showed peak blood levels of this compound in 1 hour.…”

Section: -2mentioning

confidence: 45%

“…A study which appears to contradict to the generally observed effect of food in slowing absorption is that of McKenna et al (1978), in which fasted rats appeared to absorb dichioroethylene more slowly than fed rats. Peak exhalation of dichloroethylene administered by gavage in corn oil occurred at 1 hour for fasted animals and at 30 minutes for fed rats.…”

Section: -2mentioning

confidence: 72%

“…After the oral administration of volatile halogenated hydrocarbons, the time courses of both the blood concentration and the concentration of these chemicals in exhaled air exhibit biphasic decreases (Putcha et al, 1986;Chieco et al, 1981;D'Souza et al, 1985;McKenna et al, 1978;Pegg et al, 1979). from the GI tract in two phases, an initial rapid phase and a slower long-term phase, and effects of GI contents on both phases are apparent.…”

Section: The Nature Of the Data Reflecting Gi Absorptionmentioning

confidence: 99%

“…A more 7-I systematic experimental approach, as described above, would be necessary to quantitatively define the GI absorption process for a specific chemical and specific experimental conditions. The only data analyzed that is inconsistent with a retarding effect of food or oil on absorption is that of McKenna et al (1978), in which exhalation data were presented. As discussed previously, the results of McKenna et al are consistent with direct loss of a portion of the volatile chemical from the stomach by gastric eructation.…”

Section: Gi Contents and Transit Timementioning

confidence: 99%

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Identification of Critical Biological Parameters Affecting Gastrointestinal Absorption

DeSesso¹,

Mavis²

1990

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Section: -2mentioning

confidence: 45%

Section: -2mentioning

confidence: 72%

Section: The Nature Of the Data Reflecting Gi Absorptionmentioning

confidence: 99%

Section: Gi Contents and Transit Timementioning

confidence: 99%

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Identification of Critical Biological Parameters Affecting Gastrointestinal Absorption

DeSesso¹,

Mavis²

1990

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“…In fact, thiodiacetic acid has been found in mice after administration of chloroacetic acid and S-carboxymethylcysteine (Yllner 1971b) and in rats treated with chloroacetaldehyde, chloroacetic acid and S-carboxymethylcysteine (Green and Hathway 1977). Furthermore, it has been detected as a metabolite of compounds which can be converted metabolically to chloroacetaldehyde and chloroacetic acid, such as vinyl chloride Hathway 1975, andWatanabe et al 1976), vinylidene chloride Hathway 1978a, and1978b;McKenna et al 1978;Reichert et al ICI-CH2-CH2-OHI ~ C|-CH2-CHO . CI-CH2-COOH ,,.…”

Section: Discussionmentioning

confidence: 96%

Toxicokinetics of chloroethanol in the rat after single oral administration

Grunow

Altmann

1982

Arch Toxicol

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The excretion and tissue distribution of 14C-labelled chloroethanol were studied in rats following single oral administration of 5 and 50 mg/kg body weight. At both dose levels, the radioactivity was rapidly eliminated, mainly in the urine. On the first day after application of 5 mg/kg body weight, 77.2% of the dose were found in the urine, 1.7% in the faeces, and 1.0% as carbon dioxide in the expired air. Only 2.8% were excreted by these routes during the following 3 days. The residual radioactivity remaining in the tissues after 4 days was almost equally distributed and amounted to about 0.4% of the dose in the liver and 3% in the whole organism. At the higher dose level, excretion rates and tissue concentrations were similar. Examination of the urine by anion exchange chromatography on DEAE-Sephadex revealed two metabolites which were identified by GC/MS analysis as thiodiacetic acid and thionyldiacetic acid. These metabolites represented almost the whole urinary radioactivity. They were excreted in approximately equal amounts at the low dose whereas the thiodiacetic acid predominated with about 70% of the urinary radioactivity at the high dose. Unchanged chloroethanol, chloroacetic acid, S-carboxymethylcysteine and sulphonyldiacetic acid were not found in the urine.

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Unsaturated Halogenated Hydrocarbons

Belpoggi,

Tibaldi,

Gnudi

et al. 2023

Patty's Toxicology

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This chapter contains details on 12 unsaturated halogenated hydrocarbons. The considered chemicals are 1,3‐dichloropropene (DCP), cis ‐ and trans ‐1,2‐dichloroethylene (DCE), dichloroacetylene (DCA), allyl chloride (AC), hexachlorobutadiene (HCBD), β‐chloropropene, vinylidene chloride (VDC), vinyl chloride (VC), vinyl bromide (VB), vinyl fluoride (VF), trichloroethene (TCE), and tetrachloroethene (PCE). These compounds are used as fumigants, pesticides, solvents, and chemical intermediates. This chapter follows the outline determined for compounds and includes physical and chemical properties, production and use, exposure assessment in air and workplace, toxic effects (experimental and epidemiological studies), community methods for monitoring, regulations, and guidelines.

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Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration

Cited by 60 publications

References 8 publications

Identification of Critical Biological Parameters Affecting Gastrointestinal Absorption

Identification of Critical Biological Parameters Affecting Gastrointestinal Absorption

Toxicokinetics of chloroethanol in the rat after single oral administration

Unsaturated Halogenated Hydrocarbons

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