Metabolism and Menstrual Cycle Rhythmicity of Serotonin in Primary Headaches

D’Andrea, Giovanni; Hasselmark, L.; Cananzi, A.R.; Alecci, M.; Perini, Francesco; Zamberlan, F.; Welch, K. M. A.

doi:10.1111/j.1526-4610.1995.hed3504216.x

Cited by 37 publications

(30 citation statements)

References 9 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main product of tryptophan hydroxylase is serotonin (5-HT), whereas tryptamine is the neuromodulator that derives from the decarboxylase enzyme activity [47]. Numerous studies have been done, in the last decades, to explore possible anomalies of this in indole in migraine patients with very few compelling results.…”

Section: Biochemical Tryptophan Anomalies and Painful Attackmentioning

confidence: 99%

Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism

D’Andrea¹,

Cevoli

Colavito³

et al. 2015

Neurol Sci

View full text Add to dashboard Cite

The pathogenesis of migraine as well as cluster headache (CH) is yet a debated question. In this review, we discuss the possible role of the of tyrosine and tryptophan metabolism in the pathogenesis of these primary headaches. These include the abnormalities in the synthesis of neurotransmitters: high level of DA, low level of NE and very elevated levels of octopamine and synephrine (neuromodulators) in plasma of episodic migraine without aura and CH patients. We hypothesize that the imbalance between the levels of neurotransmitters and elusive amines synthesis is due to a metabolic shift directing tyrosine toward an increased decarboxylase and reduced hydroxylase enzyme activities. The metabolic shift of the tyrosine is favored by a state of neuronal hyperexcitability and a reduced mitochondrial activity present in migraine. In addition we present biochemical studies performed in chronic migraine and chronic tension-type headache patients to verify if the same anomalies of the tyrosine and tryptophan metabolism are present in these primary headaches and, if so, their possible role in the chronicity process of CM and CTTH. The results show that important abnormalities of tyrosine metabolism are present only in CM patients (very high plasma levels of DA, NE and tryptamine). Tryptamine plasma levels were found significantly lower in both CM and CTTH patients. In view of this, we propose that migraine and, possibly, CH attacks derive from neurotransmitter and neuromodulator metabolic abnormalities in a hyperexcitable and hypoenergetic brain that spread from the frontal lobe, downstream, resulting in abnormally activated nuclei of the pain matrix. The low tryptamine plasma levels found in CM and CTTH patients suggest that these two primary chronic headaches are characterized by a common insufficient serotoninergic control of the pain threshold.

show abstract

Section: Biochemical Tryptophan Anomalies and Painful Attackmentioning

confidence: 99%

Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism

D’Andrea¹,

Cevoli

Colavito³

et al. 2015

Neurol Sci

View full text Add to dashboard Cite

show abstract

“…Changes in serotonin content were also noticed in women with menstrual migraine, in relation to the cyclic hormonal variations. In these women, platelet serotonin levels peaked in the follicular period and decreased in the luteal phase, when 5HIAA values were particularly increased [16,17]. These data suggest an aberration in menstrual cycle-related changes of serotonin in women migraineurs, possibly due to increased catabolism or reduced synthesis which predisposes these patients to migraine attacks.…”

Section: Monamine Metabolism In Migraine: Focus On Serotoninmentioning

confidence: 77%

“…The alteration of MAO-B activity in platelets was reported particularly during migraine attacks, and was more accentuated in women with migraine related to menstrual cycle; this change is not specific for migraine as it was also found in patients with tension-type headache [16].…”

Section: Platelet Enzymes In Migrainementioning

confidence: 92%

“…The latter finding was supported by early studies which demonstrated Hedman et al [1] 1988 MA Decreased beta-adrenoreceptor response to stimulation with isoprenaline Herman et al [2] 1989 MA and MwA Decreased sensitivity of platelets to PAF Takeshima et al [3] 1989 Migraine, type not specified Increased activation during cold pressure test Kovacs et al [4] 1990 MA Increased activation to ADP and PAF D'Andrea et al [5] 1994 MA and MwA Decreased collagen-induced aggregation Kitano et al [6] 1994 MA and MwA Continuous activation measured as increased values of 11-dehydrothromboxane B2 Tozzi et al [7] 1996 MA and MwA Perturbed platelet viscosity; Decreased stimulation-induced influx of external calcium through the platelet membrane; Hyperaggregation to adenosine diphosphate and collagen MA, migraine with aura; MwA, migraine without aura; PAF, platelet-activating factor S63 a reduced platelet content of serotonin that was attributed to an unidentified plasma releasing factor. The principal data on serotonin metabolism in migraine outside the attacks are summarized in Table 2 [9][10][11][12][13][14][15][16][17]. Differences in platelet serotonin content have been observed between migraine with aura and migraine without aura patients assessed between attacks [15].…”

Section: Monamine Metabolism In Migraine: Focus On Serotoninmentioning

confidence: 99%

See 1 more Smart Citation

Platelets in migraine

Sarchielli

Gallai

2001

J Headache Pain

View full text Add to dashboard Cite

Modification in platelet activation and aggregation has been demonstrated in migraine patients both during and between attacks. A different pattern in the secretion of platelet products has also been observed in patients affected by migraine compared with controls. The most important variation concerns a hyposecretion of dense body products. Platelets share structural and functional analogies with monoaminergic neurons, in particular serotoninergic neurons, and have been used as a peripheral model to study monaminergic function in migraine patients. A reduced turnover of serotonin has been shown in migraine patients in the interictal period, whereas a reduced content of this monoamine was detected in patients with chronic daily headache (CDH), particularly in those with analgesic abuse. Nitric oxide metabolism was also studied in platelets of migraine patients between and during attacks. An increased activity of nitric oxide synthase (NOS), which was more accentuated during attacks, was found in these patients compared to healthy individuals. The increase in platelet NOS activity was also confirmed in CDH patients in association with a reduction of serotonin content and increased calcium levels. Variations in aggregation to different agents and secretion may not, at the moment, be indicative of similar changes in cerebral circulation of migraine patients. Its occurrence should be confirmed in samples of jugular venous blood during attacks to establish a definite link with migraine pathogenesis. Moreover changes in serotonin and NO metabolism observed in platelets of migraine patients may only indirectly suggest similar modifications in the neuronal pathways involved in inducing and maintaining head pain in migraineurs.

show abstract

“…In addition to the menstrual cycle hormones, endogenous opioids, serotonin and adrenergic central system of many pure menstrual migraine or menstrually related migraine sufferers may be altered in the premenstrual syndrome 3,27 . Therefore, studies are needed to investigate the pattern of these hormones during the lactation period and their association with the reduction of migraine recurrence during postpartum.…”

Section: Discussionmentioning

confidence: 99%

Exclusive breastfeeding protects against postpartum migraine recurrence attacks?

Serva

Caminha³

et al. 2012

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Migraine, mainly without aura, is influenced by cyclical hormones changes that occur during the women's reproductive life [1][2][3][4] . It is predominantly during the menstrual period that attacks occur and, in some cases, exclusively 5 . The most accepted hypothesis for the physiopathology of attacks during menstruation lies in the sharp decrease of estrogens durestrogens dur-during the premenstrual period 1,5,6 . However, the majority of the pregnant women that are migraine sufferers before pregnancy show migraine improvement or even disappearance during pregnancy 7,8 . Absence of cyclical hormonal fluctuations during pregnancy, mainly estrogens that rise during this period, is pointed as one of the most important causes of such behavior 4,8 . AbsTRACT Objectives: To observe postpartum migraine recurrence among migraine sufferers before pregnancy, its classifications and associated factors and to compare women, who were exclusively breastfeeding, with those that used other forms of infant feeding. Methods: Out of 686 consecutively assisted women, at the first postnatal week, 266 were identified as migraine sufferers before pregnancy. Among those, one in five that were exclusively breastfeeding (53) and all the ones consecutively using others forms of infant feeding (40) were interviewed at the first and forth postpartum weeks. Results: After multivariable analysis, exclusive breastfeeding, no breastfeeding problems, and low income were associated with decrease in migraine recurrence at the first postpartum week. At the fourth week, exclusive breastfeeding continued to be a protective factor. Conclusions: A decrease in postpartum migraine recurrence seems to be another advantage of exclusive breastfeeding.Key words: migraine without aura, migraine with aura, breast feeding, postpartum period. REsumoObjetivos: Observar a recorrência de enxaqueca no período pós-parto em mulheres com enxaqueca antes da gestação, suas classificações e fatores associados e comparar mulheres que apenas amamentavam com aquelas que alimentavam seus filhos de outro modo. Métodos: De 686 mulheres consecutivamente assistidas na primeira semana pós-parto, 266 foram identificadas como portadoras de enxaqueca antes da gestação. Destas, uma em cada cinco que se encontravam amamentando exclusivamente (53) e aquelas que usavam outras modalidades de alimentação (40) foram entrevistadas na primeira e quarta semanas pós-parto. Resultados: Após análise multivariada, observou-se que praticar aleitamento materno exclusivo, não ter problemas relacionados à amamentação e ter baixa renda estavam associados à diminuição da recorrência da enxaqueca na primeira semana pós-parto. Na quarta semana, a prática do aleitamento materno exclusivo continuou sendo fator protetor em relação à enxaqueca. Conclusões: A diminuição da recorrência da enxaqueca pós-parto parece ser uma vantagem adicional do aleitamento materno exclusivo.Palavras-Chave: enxaqueca sem aura, enxaqueca com aura, aleitamento materno, período pós-parto.

show abstract

Metabolism and Menstrual Cycle Rhythmicity of Serotonin in Primary Headaches

Cited by 37 publications

References 9 publications

Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism

Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism

Platelets in migraine

Exclusive breastfeeding protects against postpartum migraine recurrence attacks?

Contact Info

Product

Resources

About