Metabolically healthy obese and metabolically unhealthy non-obese phenotypes in a Russian population

Rotar, О. P.; Boyarinova, M.; Орлов, А. В.; Солнцев, В. Н.; Zhernakova, Juliya V.; Шальнова, С. А.; Деев, А. Д.; Konradi, Alexandra; Баранова, Е. И.; Чазова, И Е; Boytsov, S. А.; Shlyakhto, E. V.

doi:10.1007/s10654-016-0221-z

Cited by 34 publications

(24 citation statements)

References 11 publications

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“…Taking into account the sample stratification in relation to age, it can be argued that the lowest BMI values of 24.91±3.29 kg·m -2 have been determined at the age of 18-30 years, which can be considered a limit value in relation to overweight. At the age of 30-40 years, BMI values in males reach an average of 27.74±4.26 kg·m -2 , while after the age lished, which corresponds with the results of previous research (Rotar et al, 2016).…”

Section: Discussionsupporting

confidence: 91%

BMI: Analysis of the population indicators in working population of the Republic of Serbia in relation to gender and age

Dopsaj¹,

Marković²,

Jovanović³

et al. 2018

Fizička kultura

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Section: Discussionsupporting

confidence: 91%

BMI: Analysis of the population indicators in working population of the Republic of Serbia in relation to gender and age

Dopsaj¹,

Marković²,

Jovanović³

et al. 2018

Fizička kultura

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“…BP was assessed in accordance with the guidelines on the management of arterial hypertension of the European Society of Cardiology and European Society of Hypertension [12][13][14]. An automatic tonometer "OMRON M3 Expert" (Japan) was used for the BP and HR assessment: two measurements with the 2-minute interval were performed on the right hand after 5 minutes of rest in supine posi- Blood tests included fasting lipids, creatinine and glucose (Abbott Architect 8000, Roche-diagnostics, USA), C-reactive protein (Cobas Integra 400 plus, Switzerland; Roche-diagnostics).…”

Section: Methodsmentioning

confidence: 99%

Is self-reported insomnia a risk factor for subclinical carotid atherosclerosis?

Korostovtseva

Alieva

Rotar

et al. 2019

Arterial Hypertension

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Background. Insomnia is considered an additional cardiovascular (CV) risk factor (RF). However, the data on its association with vascular damage is controversial. We analyzed the relation between self-reported insomnia and carotid atherosclerosis in the population-based sample. Material and methods. We selected 985 (males -38%; mean age 45.2 ± 11.6 years) participants of the St Petersburg population-based sample (the ESSE-RF study) who did not have previously known CV events. All subjects underwent a structured interview (lifestyle, medical history). Insomnia was diagnosed when complaints occurred ≥ 3 times/week (the questions: "How often did you have difficulties in falling asleep for > 30 min after going to bed in the last month?", "How often did you have difficulties in falling asleep after midnight awakening in the last month?"). Subclinical atherosclerosis was assessed by carotid intima-media thickness (IMT): normal ≤ 0.9 mm, increased IMT 0.9-13 mm, IMT > 13 mm indicated an atherosclerotic plaque. Results. In total, 209 subjects reported at least one insomnia complaint; 79 participants (8%) reported both sleeponset and sleep-maintenance problems. IMT thickening was found in 142 subjects (14.4%). IMT values were higher in those with frequent nocturnal awakenings vs. non-insomniacs (0.75 ± 0.18 vs. 0.71 ± 0.17 mm, p = 0.006). They also showed greater prevalence of thickened IMT (c 2 = 4.6, p = 0.026). Mean IMT weakly correlated with insomnia complaints (r = 0.10, p = 0.002), but the association was no longer significant after adjustment for age, BP and total cholesterol level. Conclusion. We demonstrated an association between insomnia complaints and subclinical carotid atherosclerosis, although we assume it to be weak compared to the common CV RF.

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“…The study was approved by the Institutional Review Boards of 3 main centers: Almazov National Medical Research Centre (St Petersburg), National Research Center for Preventive Medicine (Moscow), Russian Cardiology Research and Production Complex (Moscow) and the associate centers. Detailed study design and enrollment process were described previously elsewhere [17]. All participants gave written informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…The multicenter study "Epidemiology of cardiovascular disease in different regions of the Russian Federation -ESSE-RF" is the first epidemiological study to evaluate the sleep duration among Russians [17]. The main objective of this epidemiological study was to study the prevalence of risk factors and cardiovascular diseases in 13 regions of the Russian Federation (RF) with different climate, geographic, economic and demographic characteristics, to elaborate the risk model for Russian population, and to investigate the traditional and new cardiovascular risk factors.…”

Section: Introductionmentioning

confidence: 99%

Sleep duration and cardiovascular risk: results of the large-scale epidemiology study ESSE-RF

Bochkarev

Korostovtseva

Медведева

et al. 2019

Arterial Hypertension

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Background. The recent data suggest that sleep disorders are associated with cardiovascular diseases. We assessed the relation between self-reported sleep duration and cardiovascular and metabolic disorders in the large-scale epidemiological study. Material and methods. The ESSE-RF is a population-based cross-sectional study involving 22,258 participants aged 25-64 years from 13 regions of the Russian Federation. In 2012-2014, all subjects underwent a structured interview including questions about average daily sleep duration, lifestyle, complaints and diseases. The current analyses considered the associations with the following disorders: obesity, hypertension, coronary artery disease, myocardial infarction, stroke (cerebral thrombosis or hemorrhage) and diabetes mellitus. Results. Altogether 20,359 respondents were included in the final analysis. The mean self-reported sleep duration was 7.0 h per night: 23.3% participants reported sleeping less than 6 h while 4.5% subjects slept more than 9 h. We found both short and long sleep duration to be associated with self-reported cardiovascular diseases. The association was independent of age, sex, body mass index, blood pressure, lipids and glucose levels. The multivariable odds were higher for obesity in short-sleepers compared to those sleeping 7-8 h. In the meanwhile, the association was U-shaped for coronary artery disease. A J-shaped relation was found for myocardial infarction. No relation was found for hypertension, diabetes mellitus or stroke. Conclusions. Differences in sleep duration may have health consequences given associations between short and long sleep duration and cardiometabolic outcomes.

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Metabolically healthy obese and metabolically unhealthy non-obese phenotypes in a Russian population

Abstract: Half of obese Russian inhabitants are metabolically healthy. At the same time, metabolic abnormalities were detected in one third of non-obese participants with a shift to male gender.

Cited by 34 publications

References 11 publications

BMI: Analysis of the population indicators in working population of the Republic of Serbia in relation to gender and age

BMI: Analysis of the population indicators in working population of the Republic of Serbia in relation to gender and age

Is self-reported insomnia a risk factor for subclinical carotid atherosclerosis?

Sleep duration and cardiovascular risk: results of the large-scale epidemiology study ESSE-RF

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