Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer

FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma

“…Fructose-1, 6-biphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis that converts fructose-1, 6-bisphosphate to fructose-6-phosphate and negatively regulates aerobic glycolysis in pancreatic cancer cells [ 15 ]. The reduction of FBP1 expression in pancreatic cancer tissue compared with adjacent normal tissue is associated with a poor prognosis [ 16 , 17 ]. Therefore, FBP1 functions as a tumor suppressor in pancreatic cancers.…”

The clinical utility of CA125/MUC16 in pancreatic cancer: A consensus of diagnostic, prognostic and predictive updates by the Chinese Study Group for Pancreatic Cancer (CSPAC)

“…when 18 F-FDG PET/CT was not available, we used CA19-9 and CA125 levels to establish equations for metabolic tumor volume (MTV) and total lesion glycolysis (TLG) based on their functional properties reflecting metabolic tumor burden. Our results suggested that the metabolic tumor burden estimated by serum tumor biomarkers may be suitable for monitoring the response to treatment and the progression of pC (49). Recently, we reported that pre-operative CA125 levels can predict post-operative early recurrence (Liu et al, unpublished data).…”

“…we recommend the use of CA125 for diagnosis (including metastasis and differential diagnosis between benign and malignant diseases), particularlyy in cases which are CA19-9-negative. Simultaneous assessments, including various biomarkers, oncogenomic analyses and functional imaging tests, such as positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography ( 18 FDG pET/CT) are important for the accurate diagnosis of pC (47)(48)(49)(50).…”

18F-Fluorodeoxyglucose positron emission tomography/computed tomography comparison of gastric lymphoma and gastric carcinoma

“…However, SUVmax is a single voxel value that shows the highest intensity of 18 F-FDG uptake within the region of interest and may not represent total tumor metabolism[32]. Instead of SUVmax, volumetric parameters of metabolism such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) derived from 18 F-FDG PET have been recently used for differential analysis, stage stratification survival analysis, and oncogenomic alteration for a variety of malignancies, such as pancreatic cancer[33], non-small-cell lung cancer[34] and head and neck cancer[35]. In view of the potential clinical value of MTV and TLG in the diagnostic performance of PET/CT, we will focus on differentiating gastric lymphoma from gastric carcinoma based on these volumetric parameters of metabolism, and perform a correlation analysis between prognosis and MTV or TLG.…”