Metabolic, toxicological, and safety considerations for drugs used to treat ADHD

Duong, Sophie; Chung, Kara; Wigal, Sharon B.

doi:10.1517/17425255.2012.671295

Cited by 30 publications

(20 citation statements)

References 59 publications

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“…For example, sleep disturbances, which are often reported in individuals with MDD, 38 are also adverse events that can be associated with psychostimulant medications. 33 In bipolar disorder, treatment with stimulant medications can be associated with the acute onset or exacerbation of mania/ hypomania, 14 so nonstimulant options for treating ADHD may be warranted.…”

Section: Mood Disordersmentioning

confidence: 99%

Comorbidities in Adult Attention-Deficit/Hyperactivity Disorder: A Practical Guide to Diagnosis in Primary Care

Mao

Findling

2014

Postgraduate Medicine

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Diagnosis and management of attention-deficit/hyperactivity disorder (ADHD) in adults is complex and challenging because of the frequent comorbidity of other psychiatric disorders that have symptoms overlapping with those of ADHD. The presence of comorbidities can create challenges to making an accurate diagnosis and also impact treatment options and outcomes. This review discusses disorders that may be comorbid with ADHD in adults, including anxiety, mood, substance use disorder, antisocial personality disorder, and borderline personality disorder. Suggestions for recognizing these comorbidities and distinguishing them from ADHD and perspectives on their possible impact on ADHD treatment are included. Adjunctive nonpharmacologic modalities may be especially helpful in the case of comorbid mood, anxiety, substance abuse, or personality disorders.

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Section: Mood Disordersmentioning

confidence: 99%

Comorbidities in Adult Attention-Deficit/Hyperactivity Disorder: A Practical Guide to Diagnosis in Primary Care

Mao

Findling

2014

Postgraduate Medicine

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“…The prevalence of ADHD is as high as 5-10% in children and 2.4-5% in adolescents [130][131][132]. Monotherapy with amphetamines or with methylphenidate (MPH) is the first-line pharmacological treatment of ADHD [130].…”

Section: Methylphenidatementioning

confidence: 99%

“…Monotherapy with amphetamines or with methylphenidate (MPH) is the first-line pharmacological treatment of ADHD [130]. The Daytrana® patch ( [132,134].…”

Section: Methylphenidatementioning

confidence: 99%

“…Because both clearance and first-pass effect are stereo selective, the d/l enantiomer ratio differs after oral and transdermal administration [132,136]. Typically, very low levels (if any) of l-MPH are detectable after oral administration [130,132,136]; in contrast, they are significantly higher (x50 fold) after transdermal delivery even though this enantiomer contributes only ~5-10% of the drug's pharmacological activity. Application of the patch to an inflamed skin site reduced the d-MPH lag time to less than one hour, t max to only 4 h, and caused a 3-fold increase in C max and AUC [131].…”

Section: Methylphenidatementioning

confidence: 99%

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Effective use of transdermal drug delivery in children

Delgado‐Charro

Guy

2014

Advanced Drug Delivery Reviews

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“…La importancia de estudiar la interacción de estas tres funciones ejecutivas se orienta en la posibilidad de desarrollar técnicas de tratamiento basadas en el funcionamiento ejecutivo como método primordial en el abordaje terapéutico de esta población infantil (Cantwell, 1996;DeBonis, 2010;Duong, Chung & Wigal, 2012;Valverde & Inchauspe, 2014).…”

Section: Introductionunclassified

Control inhibitorio, monitorización y habla autodirigida en el Trastorno por Déficit de Atención con Hiperactividad

Ramos

Pérez-Salas

Lepe

2016

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Resumen: El trastorno por déficit de atención con hiperactividad (TDAH) es un trastorno del neurodesarrollo que afecta aproximadamente entre el 3% y 10% de la población infantil. En lo empírico y teórico se ha descrito que las alteraciones en el control inhibitorio, monitorización y habla autodirigida serían aspectos cognitivos deficitarios en este cuadro clínico. En el presente artículo realizamos una revisión de artículos indexados en las principales bases de datos que reportan estudios empíricos y propuestas teóricas sobre el control inhibitorio, monitorización y el habla autodirigida en población con trastorno por déficit de atención con hiperactividad. Como conclusión se afirma que las funciones ejecutivas descritas podrían componer modelos explicativos de la sintomatología del TDAH en donde se presente una interacción entre las mismas, lo cual aportaría en la comprensión de este trastorno y en su tratamiento.Palabras clave: trastorno por déficit de atención con hiperactividad, monitorización, control inhibitorio, habla autodirigida, función ejecutiva. Control inhibitorio Abstract:ADHD is a neurodevelopmental disorder that affects approximately 3% to 10% of the child population. Theory and research in this field have described that alterations in the inhibitory control, monitoring and self-directed speech are the most deficient cognitive aspects in clinical cases like these. In this article we review the conceptualization of ADHD clinical perspective of this disorder, gender differences and describe the major deficits of executive function present in this disorder. In this article we review articles indexed in major databases that report empirical and theoretical proposals on inhibitory control, monitoring and self-directed population speaks attention deficit disorder with hyperactivity. In conclusion states that executive functions described could compose explanatory models of ADHD symptomatology where an interaction between them, which would contribute to the understanding of this disorder and its treatment is present.

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Metabolic, toxicological, and safety considerations for drugs used to treat ADHD

Cited by 30 publications

References 59 publications

Comorbidities in Adult Attention-Deficit/Hyperactivity Disorder: A Practical Guide to Diagnosis in Primary Care

Comorbidities in Adult Attention-Deficit/Hyperactivity Disorder: A Practical Guide to Diagnosis in Primary Care

Effective use of transdermal drug delivery in children

Control inhibitorio, monitorización y habla autodirigida en el Trastorno por Déficit de Atención con Hiperactividad

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