Metabolic syndrome reduces bone mineral density in overweight adolescents

Silva, Valéria Nóbrega da; Goldberg, Tamara Beres Lederer; Mosca, Luciana Nunes; Rizzo, Anapaula da Conceição Bisi; Teixeira, Altamir dos Santos; Corrente, José Eduardo

doi:10.1016/j.bone.2014.05.011

Cited by 22 publications

(28 citation statements)

References 34 publications

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“…Nonetheless, some of the factors that are released by peripheral fat accumulation into the circulation (adipokines and inflammatory markers) may in turn have a deleterious effect on bone mass. "Osteopenia/osteoporosis", sarcopenia, and obesity are commonly observed in the process of aging, and recent evidence suggested a potential interconnection of these conditions with common pathophysiology, even though this interaction is still poorly understood [51][52][53][54][55][56]. So far, few studies have evaluated the relationship between adiposity, including adipokines, and BMD among ALL survivors [47,56].…”

Section: Causes Of Low Bone Mineral Density Among Acute Lymphoblasticmentioning

confidence: 99%

Are Survivors of Childhood Acute Lymphoblastic Leukemia at Increased Risk for Low Bone Mass?

Siviero-Miachon¹,

Lee²,

Guerra‐Júnior

et al. 2014

J Leuk

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Acute lymphoblastic leukemia is the most prevalent cancer in children. As an increasing number of cancer survivors reaches adulthood, there may be consequences of the treatment, and there is an issue if low bone mass might be included as a significant late effect. Acute lymphoblastic leukemia patients may have their bone mass compromised during therapy and many years after its withdrawal, but the degree of bone mass decline or recovery are not well elucidated to date. Survivors of stem cell transplantation for leukemia have additional risk factors for bone loss and should be evaluated with caution. Our target is to make a warning about the difficulties in assessing and interpreting bone mass in children and adolescents, the limitations in this assessment in acute lymphoblastic leukemia young survivors (including survivors of stem cell transplantation), the possibility of misdiagnoses, the reasons (if there are any) of low bone mass in this particular group of cancer survivors, as well as consider the therapeutic issues available.

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Section: Causes Of Low Bone Mineral Density Among Acute Lymphoblasticmentioning

confidence: 99%

Are Survivors of Childhood Acute Lymphoblastic Leukemia at Increased Risk for Low Bone Mass?

Siviero-Miachon¹,

Lee²,

Guerra‐Júnior

et al. 2014

J Leuk

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“…This combination of metabolic alterations predisposes affected individuals to the development of cardiovascular diseases and type 2 diabetes mellitus [1, 2]. In addition to the cardiovascular problems extensively documented in the scientific literature, previous studies have shown a possible relationship between MetS and bone mass, however the results are still inconsistent [3–7]. …”

Section: Introductionmentioning

confidence: 99%

“…Another hypothesis to explain the diversity of the results of already published studies is the fact that the presence of MetS associated with a reduction in BMD was demonstrated for other ethnic groups and younger individuals, and therefore depends on the population studied. With respect to adolescence, literature reviews on the relationship between MetS and BMD are sparse [4, 5, 7]. …”

Section: Introductionmentioning

confidence: 99%

“…Literature reviews on the relationship between a diagnosis of MetS and risk factors during puberty and BMD in adolescents are sparse [4, 5, 7, 14–16]. Table 1 shows the results of some studies on the topic found in the scientific literature according to date of publication and interest in investigating the risk factors of metabolic syndrome, with bone mass evaluated through densitometry in adolescents.…”

Section: Introductionmentioning

confidence: 99%

“…[16]Georgia/USA140 overweight(7 to 11 years)Cross-sectionalBMC and BMD using DXAPre-diabetes ↓BMC and BMDHyperinsulinemia ↓BMC and BMDPollock et al . [4]Georgia/USA143 overweight adolescents with cardiometabolic risk factors (14 to 18 years)Cross-sectionalBMC using DXA↑HDL-c ↑BMC≥2 MetS components ↓BMCIncreased WC ↑visceral adipose tissue, fasting insulin andHOMA-IR ↓total body BMCLawlor et al [5]United Kingdom2035 adolescents(15 years)Cross-sectionalBMD and BMC using DXAHypertriglyceridemia ↑BMD, BMC and in boysReduced HDL and insulin resistance ↓total body BMD, BMCLee et al [14]South Korea618 adolescents(10 to 19 years)Cross-sectionalBMC using DXAHOMA-IR ↓BMC in boysNóbrega da Silva et al [7]Brazil270 overweight adolescents(10 to 16 years)Cross-sectionalBMD using DXAMetS (+)↓BMD/kg weight lumbar spine, left proximal femur, total and subtotal bodyIncreased WC ↓BMD (lumbar spine and total body) in both gendersHypertriglyceridemia ↓BMD (lumbar spine and total body) in girls. BMC bone mineral content, BMD bone mineral density, MetS(+) with metabolic syndrome, WC waist circumference …”

Section: Introductionmentioning

confidence: 99%

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Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?

Silva

Fiorelli

Silva³

et al. 2017

Nutr Metab (Lond)

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In recent years, there has been growing concern about the occurrence of metabolic syndrome (MetS) at an early age and its effects on bone mass in adolescents. Adolescence is considered a critical period for bone mass gain. Impaired bone acquisition during this phase can lead to “suboptimal” peak bone mass and increase the risk of osteopenia/osteoporosis and fractures in old age. The objective of this review was to perform a critical analysis of articles that specifically focus on this age group, evaluating the influence of MetS and its components on bone mineral density in adolescents. A possible relationship between this syndrome and bone mass has been demonstrated, but the number of studies addressing this topic in adolescents is small. Despite the scarcity of evidence, the results of those studies show that Metabolic Syndrome is negatively correlated with bone mass and also that some components of MetS are negatively correlated with bone mineral density in adolescents. However, the associations between MetS and bone mass development need to be further explored in the age group corresponding to adolescence. Further good-quality studies are necessary to complement the understanding of this relationship.

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