Insulin resistance and bone health in adolescents

Karimi, Fariba; Omrani, Gholamhossein Ranjbar; Dabbaghmanesh, Mohammad Hossein

doi:10.1007/s11657-021-00917-6

Cited by 5 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These factors likely contribute to different patterns of bone acquisition across the growing years in individuals with obesity and insulin resistance. Karimi et al [50] evaluated cross-sectional associations between HOMA-IR and bone outcomes from DXA in 423 boys and girls ages 9-19 years. In unadjusted analyses, HOMA-IR was positively associated with BMD at most skeletal regions, but after accounting for sex, age, BMI, puberty, physical activity, fat mass, and lean mass, many of these associations were negative.…”

Section: Key Pointsmentioning

confidence: 99%

“…Most recent clinical studies evaluating relationships between insulin resistance and bone health have used dual-energy X-ray absorptiometry (DXA) to assess BMD and bone mineral content (BMC) [17 , [45][46][47][48][49][50][51]. Bone outcomes from DXA have strong clinical application, but DXA is limited by its inability to distinguish between cortical and trabecular bone compartments because of its two-dimensional…”

Section: Clinical Studies Of Insulin Resistance and Bone Healthmentioning

confidence: 99%

See 1 more Smart Citation

Insulin resistance and skeletal health

Lei

Kindler

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Purpose of reviewBone fragility is a complication of type 2 diabetes (T2D), and insulin resistance is suspected to contribute to diabetes-related bone deficits. This article provides an overview of emerging clinical research involving insulin resistance and bone health by summarizing recent publications, identifying existing knowledge gaps, and suggesting 'next steps' for this evolving field of research. Recent findingsClinical studies in children and adults report greater bone density in people with increased insulin resistance, but these associations are often attenuated when adjusting for body size. Advancements in bone imaging methods allow for assessment of nuanced characteristics of bone quality and strength that extend beyond standard bone mineral density assessment methods. For example, several recent studies focusing on lumbar spine trabecular bone score, a relatively new measure of trabecular bone quality from dual-energy X-ray absorptiometry, have reported generally consistent inverse associations with insulin resistance. Longitudinal studies using advanced imaging methods capable of evaluating trabecular bone microstructure and strength, such as high-resolution peripheral quantitative computed tomography, are lacking. Studies in younger individuals are sparse, but emerging data suggest that peak bone mass attainment might be threatened by diabetes progression, and increased visceral fat, suppressed muscle-bone unit, advanced glycation endproducts, sedentary lifestyle, and poor diet quality might contribute to diabetes effects on bone. Prospective studies during the transition from adolescence to young adulthood are required.

show abstract

Section: Key Pointsmentioning

confidence: 99%

Section: Clinical Studies Of Insulin Resistance and Bone Healthmentioning

confidence: 99%

Insulin resistance and skeletal health

Lei

Kindler

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

show abstract

Pubertal increment in insulin resistance is negatively related to lumbar bone mineral density in 18-year-old males

et al. 2022

View full text Add to dashboard Cite

Relationships between obesity markers and bone parameters in community-dwelling older adults

Lemoine,

Buckinx,

Aidoud

et al. 2024

Aging Clin Exp Res

View full text Add to dashboard Cite

Background Osteoporosis is an age-related condition that can lead to fragility fractures and other serious consequences. The literature data on the impact of obesity on bone health are contradictory. The main reasons for this discrepancy could be the imperfect nature of the body mass index (BMI) as a marker of obesity, the metabolic status (inflammation and metabolically healthy obesity), and/or heterogeneity in bone variables and architecture or sex. Aims To examine the relationship between bone variables and three validated obesity criteria. Methods In this cross-sectional study, participants were classified as obese according to their BMI, waist circumference (WC), and fat mass (FM). Bone variables and architecture were assessed using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, respectively. Results One hundred sixty-eight adults aged 55 or over (men: 68%) were included. 48 (28%) participants were obese according to the BMI, with 108 (64%) according to the FM, and 146 (87%) according to the WC. Bone variables were positively correlated with WC and BMI (Pearson’s r = 0.2–0.42). In men only, the obesity measures were negatively correlated with cortical bone density (Pearson’s r = − 0.32 to − 0.19) and positively correlated with cortical bone area (Pearson’s r = 0.22–0.39). Conclusion Our findings indicate that independent of sex and obesity criteria, when significant, being obese seems to lead to higher bone parameters than being non-obese, except for cortical bone density. Thus, in the obese population, assessing cortical density might help the physician to identify bone alteration. Further researches are needed to confirm our findings.

show abstract

Insulin resistance and bone health in adolescents

Cited by 5 publications

References 44 publications

Insulin resistance and skeletal health

Insulin resistance and skeletal health

Pubertal increment in insulin resistance is negatively related to lumbar bone mineral density in 18-year-old males

Relationships between obesity markers and bone parameters in community-dwelling older adults

Contact Info

Product

Resources

About