Metabolic syndrome – Neurotrophic hypothesis

Hristova, Mariyana G.; Aloe, Luigi

doi:10.1016/j.mehy.2005.08.055

Cited by 75 publications

(42 citation statements)

References 26 publications

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“…The increase in TNF-α and IL-6 serum levels in MetS also play a role in the pathogenesis in psoriasis patients (2)(3)(4)(5)(6)(7)29). TNF-α and IL-6 serum and tissue levels were similar in all three groups in our study.…”

Section: Discussionsupporting

confidence: 66%

“…Tumor necrosis factor-α (TNF), interleukin-1β (IL), IL-6, IL-8, IL-10, haptoglobulin, leptin and adiponectin are secreted from adipose tissue and initiate inflammation by passing into the circulation. The neurotrophins (NTs) are composed of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), NT-3, NT-4 and NT-5 and are believed to be associated with inflammatory diseases as well as MetS (4,5). In recent studies, NTs have been reported to be effective not only on the peripheral and central nervous system but also on the immune and endocrine systems (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the Role of Neurotrophins in the Psoriasis and Metabolic Syndrome Relationship

Bulur¹,

Erdoğan²,

Çiftçi³

et al. 2017

tdd

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ÖzAmaç: Psoriasis hastalarında ve sağlıklı kontrollerde serum ve deri örneklerinde beyin türevli nörotrofik faktör (BDNF), sinir büyüme faktörü (NGF), tümör nekroz faktör-α (TNF) ve interlökin-6 (IL) düzeylerini belirleyerek metabolik sendrom (MetS) ve psoriasis ilişkisinde nörotrofinlerin yerini değerlendirmeyi amaçladık. Yöntemler: Serum BDNF, NGF, TNF-α ve IL-6 düzeyleri ticari hazır ELISA kitleri ile değerlendirildi. BDNF, NGF, TNF-α ve IL-6 antikorları ile BDNF, NGF, TNF-α ve IL-6'nın derideki ekspresyon düzeyi belirlendi. Bulgular: MetS risk faktörlerinden herhangi birinin eşlik etmediği 39 psoriasis vulgaris hastası, MetS'nin eşlik ettiği 21 psoriasis vulgaris hastası ile 15 sağlıklı kontrol çalışmaya dahil edildi. BDNF'nin serum, epidermal ve dermal infiltrasyon düzeyi kontrol grubunda psoriasis hastalarına göre belirgin olarak yüksek saptandı (p=0,017; p=0,019; p=0,002). Serum NGF, TNF-α ve IL-6 düzeyleri açısından gruplar arasında farklılık saptanmaz iken (p˃0,05), psoriasis hastalarında epidermiste NGF'nin infiltrasyon düzeyi kontrol grubuna göre daha fazla olup istatistiksel olarak anlamlı fark tespit edildi (p=0,003). Psoriasis hasta grupları arasında ise serum BDNF düzeyi, epidermal ve dermal BDNF infiltrasyon düzeyi ve epidermal NGF infiltrasyon düzeyi ise benzerdi (p>0,05). Sonuç: Çalışmamızdaki sonuçlar nörotrofinlerin psoriasis patogenezindeki yerini desteklemektedir. Ancak çalışmamızda psoriasis grupları arasında serum ve doku BDNF, NGF düzeylerinin değişmemiş olması, psoriasis immünopatogenezinde nörotrofinlerin metabolik durumdan bağımsız olarak inflamatuvar süreç ile ilişkili olduğunu düşündürmüştür. Anahtar kelimeler: Beyin türevli nörotrofik faktör, sinir büyüme faktörü, nörotrofin, metabolik sendrom, psoriasis, immünopatogenez Objective: We aimed to evaluate the role of neurotrophins in relation to metabolic syndrome (MetS) and psoriasis by determining brain derived neurotrophic hormon (BDNF), nerve growth factor (NGF), tumor necrosis factor-α (TNF) and interleukin-6 (IL) levels in serum and skin samples of psoriasis patients and healthy controls. Methods: The BDNF, NGF, TNF-α and IL-6 levels were assessed using commercially available ELISA kits. The level of expression BDNF, NGF, TNF-α and IL-6 antibodies was determined by BDNF, NGF, TNF-α and IL-6 Antibodies. Results: Thirty nine psoriasis vulgaris patients without MetS risk factors, 21 patients with psoriasis vulgaris accompanied by MetS and 15 healthy controls were included in the study. The serum BDNF levels, epidermal and the dermal infiltration levels of BDNF were significantly higher in the control group than in the psoriasis patients (p=0.017, p=0.019, p=0.002). There was no difference between the groups in terms of serum NGF, TNF-α and IL-6 levels (p˃0.05), but the infiltration level of NGF in the epidermis was higher in the psoriasis patients than the control group and statistically significant difference was found (p=0.003). Serum BDNF levels, epidermal and dermal BDNF infiltration level and the epidermal NGF stainin...

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Evaluating the Role of Neurotrophins in the Psoriasis and Metabolic Syndrome Relationship

Bulur¹,

Erdoğan²,

Çiftçi³

et al. 2017

tdd

View full text Add to dashboard Cite

show abstract

“…Moreover, HC and hypertriglyceridemia are often associated with DM and this increment may be explained on the basis of STZ-induced diabetes; there is excess of fatty acids in the serum, which promotes conversion of excess fatty acids into phospholipids and cholesterol in the liver. The significant elevation in lipid profile in serum of HC-HG rats was achieved also by Hristova and Aloe [61] and Borai et al [2], who attributed hyperlipidemia in DM to elevated level of cortisol, which has an important role in the process of fat accumulation as cortisol promotes the liberation of free fatty acids from adipose tissue into blood stream by inducing and maintaining the synthesis of the hormone sensitive lipase, thus increasing free fatty acids level which contributes to cardio-vascular risk.…”

Section: Histopathological Investigationsupporting

confidence: 56%

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

Abduallah¹,

Abd‐Alla²,

Ali³

et al. 2016

Asian J Pharm Clin Res

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Objective: This study in bioinformatics aims to investigate the potential effect of Ipomoea tricolor and Sophora tomentosa on liver function enzymes activity, serum lipid profile, oxidative stress biomarkers, and on blood glucose in high fat diet-induced hypercholesterolemia (HC) and STZ-induced hyperglycemia (HG) in rats.Methods: Blood glucose level, liver function enzymes, alanine aminotransferases and aspartate aminotransferases, alkaline phosphatase, and lactate dehydrogenase (LDH) were determined. Besides, lipid profile including total cholesterol (TC), triacylglycerol (TG), total lipid, and high-density lipoprotein-cholesterol was investigated. Moreover, oxidative stress biomarkers, lipid peroxide, and nitric oxide as well as non-enzymatic antioxidant, glutathione (GSH) were also examined in different therapeutic groups.Results: A significant increase in blood glucose level, liver function enzyme activities, LDH, lipid profile and oxidative stress markers, while significant decrease in LDH-C and GSH level in HC-HG induced rats compared to control one. A marked amelioration in all biochemical parameters under investigation on treatment of HC-HG rats with I. tricolor and S. tomentosa with different fluctuating percentages of improvement. Histopathological examination of liver and pancreas was also performed and declared HC-HG showed congestion in portal vessels and sinusoids with mild centrilobular hepatocyte degeneration, marked hepatocyte ballooning and hydropic degeneration, while HC-HG treated rats with I. tricolor and S. tomentosa showed normal lobular hepatic architecture with mild sinusoidal dilatation and congestion. On the other hand, a histological organization of pancreas of HC-HG rats showing disarrangement changes in pancreatic blood vessels and interlobular duct as well as disordered in acini. The treatment of HC-HG rats with I. tricolor and S. tomentosa showed enhancement in Langerhans cells and restore of most pancreatic tissue in comparison with standard drugs. Conclusion:The statistical results showed that each extract ameliorated high blood glucose level liver injury, HC and oxidative stress indicating relieving of oxidative damage associated with the complexity of HG and HC. These results demonstrated that these two plants extracts may be a candidate intelligent antioxidant, hypolipidemic, hypoglycemic, and hepatoprotective nutraceuticals which need further clinical investigation to be applied effectively to reduce perturbation in HC associated diabetes.

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“…In addition to major depression, reduced serum and plasma BDNF levels have also recently been reported in several other disorders including; schizophrenia (26), bipolar disorder (27), eating disorders such as bulimia nervosa and anorexia nervosa (28), Huntington's disease (29), Alzheimer's disease (30), autism (31) and even lower respiratory infections (32). Interestingly, there are also several recent reports suggesting that BDNF levels are decreased in individuals with type-2 diabetes (33,34) and purporting a link between reduced circulating BDNF levels and metabolic syndrome (35,36). Although the seemingly non-specific association of reduced serum BDNF levels to a broad range of disorders detracts from its appeal as a specific diagnostic biomarker, it may inform us about a common pathophysiological mechanism that is shared by several different disease processes.…”

Section: What Is the Utility Of The Measure As A Biomarker?mentioning

confidence: 98%

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen

Duman

Sanacora

2008

Biological Psychiatry

1,072

706

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Metabolic syndrome – Neurotrophic hypothesis

Cited by 75 publications

References 26 publications

Evaluating the Role of Neurotrophins in the Psoriasis and Metabolic Syndrome Relationship

Evaluating the Role of Neurotrophins in the Psoriasis and Metabolic Syndrome Relationship

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

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