Evaluating the Role of Neurotrophins in the Psoriasis and Metabolic Syndrome Relationship

Abstract

ÖzAmaç: Psoriasis hastalarında ve sağlıklı kontrollerde serum ve deri örneklerinde beyin türevli nörotrofik faktör (BDNF), sinir büyüme faktörü (NGF), tümör nekroz faktör-α (TNF) ve interlökin-6 (IL) düzeylerini belirleyerek metabolik sendrom (MetS) ve psoriasis ilişkisinde nörotrofinlerin yerini değerlendirmeyi amaçladık. Yöntemler: Serum BDNF, NGF, TNF-α ve IL-6 düzeyleri ticari hazır ELISA kitleri ile değerlendirildi. BDNF, NGF, TNF-α ve IL-6 antikorları ile BDNF, NGF, TNF-α ve IL-6'nın derideki ekspresyon düzeyi belirlendi. Bulgular: MetS risk faktörlerinden herhangi birinin eşlik etmediği 39 psoriasis vulgaris hastası, MetS'nin eşlik ettiği 21 psoriasis vulgaris hastası ile 15 sağlıklı kontrol çalışmaya dahil edildi. BDNF'nin serum, epidermal ve dermal infiltrasyon düzeyi kontrol grubunda psoriasis hastalarına göre belirgin olarak yüksek saptandı (p=0,017; p=0,019; p=0,002). Serum NGF, TNF-α ve IL-6 düzeyleri açısından gruplar arasında farklılık saptanmaz iken (p˃0,05), psoriasis hastalarında epidermiste NGF'nin infiltrasyon düzeyi kontrol grubuna göre daha fazla olup istatistiksel olarak anlamlı fark tespit edildi (p=0,003). Psoriasis hasta grupları arasında ise serum BDNF düzeyi, epidermal ve dermal BDNF infiltrasyon düzeyi ve epidermal NGF infiltrasyon düzeyi ise benzerdi (p>0,05). Sonuç: Çalışmamızdaki sonuçlar nörotrofinlerin psoriasis patogenezindeki yerini desteklemektedir. Ancak çalışmamızda psoriasis grupları arasında serum ve doku BDNF, NGF düzeylerinin değişmemiş olması, psoriasis immünopatogenezinde nörotrofinlerin metabolik durumdan bağımsız olarak inflamatuvar süreç ile ilişkili olduğunu düşündürmüştür. Anahtar kelimeler: Beyin türevli nörotrofik faktör, sinir büyüme faktörü, nörotrofin, metabolik sendrom, psoriasis, immünopatogenez Objective: We aimed to evaluate the role of neurotrophins in relation to metabolic syndrome (MetS) and psoriasis by determining brain derived neurotrophic hormon (BDNF), nerve growth factor (NGF), tumor necrosis factor-α (TNF) and interleukin-6 (IL) levels in serum and skin samples of psoriasis patients and healthy controls. Methods: The BDNF, NGF, TNF-α and IL-6 levels were assessed using commercially available ELISA kits. The level of expression BDNF, NGF, TNF-α and IL-6 antibodies was determined by BDNF, NGF, TNF-α and IL-6 Antibodies. Results: Thirty nine psoriasis vulgaris patients without MetS risk factors, 21 patients with psoriasis vulgaris accompanied by MetS and 15 healthy controls were included in the study. The serum BDNF levels, epidermal and the dermal infiltration levels of BDNF were significantly higher in the control group than in the psoriasis patients (p=0.017, p=0.019, p=0.002). There was no difference between the groups in terms of serum NGF, TNF-α and IL-6 levels (p˃0.05), but the infiltration level of NGF in the epidermis was higher in the psoriasis patients than the control group and statistically significant difference was found (p=0.003). Serum BDNF levels, epidermal and dermal BDNF infiltration level and the epidermal NGF stainin...

Metabolic Syndrome Screening and Nutritional Status of Patients with Psoriasis: A Scoping Review

“…Study characteristics are presented in Table 1 . A total of 61.9% of the studies were from Asian countries [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ], and 52.4% were case-control studies [ 29 , 31 , 33 , 37 , 38 , 41 , 42 , 43 , 44 , 45 , 46 ] with a total of 4286 participants. Eight studies matched participants with age and sex [ 31 , 33 , 34 , 37 , 38 , 42 , 43 , 44 ], three studies matched for BMI [ 35 , 41 , 45 ] and only one study matched for ethnicity [ 45 ].…”

“…Eight studies matched participants with age and sex [ 31 , 33 , 34 , 37 , 38 , 42 , 43 , 44 ], three studies matched for BMI [ 35 , 41 , 45 ] and only one study matched for ethnicity [ 45 ]. A total of 71.4% of studies had a higher number of males compared to females [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 37 , 38 , 40 , 41 , 44 , 46 , 47 ]. In total, 52.4% of patients with psoriasis were between 40 and 50 years old [ 30 , 31 , 32 , 35 , 36 , 38 , 39 , 41 , 44 , 46 , 47 ].…”

“…There were four MetS definition criteria used to define MetS in the included studies, as shown in Table 2 . In total, 57.1% of the studies used NCEP ATP II criteria [ 28 , 29 , 31 , 32 , 33 , 35 , 37 , 38 , 39 , 42 , 43 , 48 ], and 33.3% were using International Diabetes Federation (IDF) criteria for MetS [ 30 , 34 , 36 , 38 , 40 , 41 , 44 ]. Two studies used the harmonised guideline [ 45 , 47 ], and one study used the Polish Forum of Prevention criteria [ 46 ].…”

“…Although waist circumference was measured in all studies, two studies did not report any values [ 29 , 35 ]. Variations in the cut-offs for the waist circumference were observed.…”

Leptin Receptor (rs1137101) and Brain-Derived Neurotrophic Factor (rs925946) Gene Variants Are Associated with Obesity in the Early- but Not in the Late-Onset Population of Hungarian Psoriatic Patients

“…Regarding psoriasis, BDNF was found to be crucial in the maintenance of normal keratinocyte apoptosis and epidermal homeostasis [ 63 ], while p75NTR protein was found to be absent in lesional psoriasis skin. Regarding its serum levels as well as its staining intensities, significantly lower levels were detected in both the epidermis and the dermis of psoriatic patients compared to the control group; however, no difference was observed between the psoriasis patients with and without MetS [ 63 , 64 , 65 ]. Interestingly, in assessing the polymorphism rs6265 in the BDNF gene, its combined effect with higher BMI was found to increase the risk and clinical severity of psoriasis in the Chinese Han population [ 66 ]; nevertheless, as shown in both this and our previous [ 21 ] studies, we found no significant results in the case of rs6265 in our psoriasis cohort.…”