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Introduction. With the growth of urbanization processes, the problem of professional exposure to electric and magnetic fields of industrial frequency is an increasingly relevant topic. Recently, the scientists paid a special attention to the long-term health consequences associated with prolonged exposure to harmful physical factors. The previously obtained data on the increase in the levels of lipid metabolism and hormonal and metabolic disorders in workers exposed to electric and magnetic fields of industrial frequency determine the relevance of studying adipokine metabolism and assessing genetic risk factors for predisposition to cardiovascular pathology in employees of the electric power industry. The study aims to research the relationship of biochemical and molecular genetic markers of adipokine metabolism with indicators of hormonal and metabolic disorders for a comprehensive assessment of cardiovascular risk in workers exposed to electric and magnetic fields of industrial frequency. Materials and methods. The researchers examined 144 employees of the main group engaged in the repair and operation of power grid facilities and 40 employees of the control group who are not exposed to electromagnetic fields of industrial frequency.The concentration of leptin and adiponectin was determined in blood serum samples. The authors have calculated the ratio of adiponectin to leptin. We have performed a molecular genetic study of single nucleotide polymorphisms of leptin (LEP) G2548A (rs7799039), leptin receptor (LEPR) A668G (rs1137101) and adiponectin type two receptor (ADIPOR2) G795A (rs16928751) genes. Results. The staff of the main group revealed a higher level of leptin (8.1 (3.7; 14.4) ng/ml) relative to the same indicator in the control group (6.0 (4.1; 11.1) ng/ml), p<0.028. Levels of leptin and adiponectin moderately and weakly correlate with hormonal and metabolic parameters. In the group of employees with less than 10 years of experience, a higher level of adiponectin was established compared to the group with 11–20 years of experience (6.1 (4.6; 9.1) mcg/ml and 4.5 (3.6; 6.4) mcg/ml, respectively); with an increase in work experience of more than 20 years, a significant increase in the concentration of leptin was found (p<0.05). Scientists have identified the significance of single-nucleotide polymorphisms of the LEPR, LEP, ADIPOR2 genes in the development of abdominal obesity, an increase in cholesterol levels and a decrease in the level of total testosterone in workers exposed to electric and magnetic fields of industrial frequency. Limitations. The study is limited to the number of surveyed (144 employees). Conclusion. The results of the study indicate the relationship of biochemical and molecular genetic markers of adipokine metabolism with indicators of hormonal and metabolic disorders in employees exposed to electric and magnetic fields of industrial frequency. When examining workers exposed to electric and magnetic fields of industrial frequency, the use of clinical and laboratory markers of adipokine metabolism (biochemical, molecular genetic) is informative in a comprehensive assessment of cardiovascular risk. Ethics. The work complies with ethical standards developed in accordance with the Helsinki Declaration of the World Medical Association "Ethical Principles of conducting Scientific medical research with human participation" as amended in 2000 and the "Rules of Clinical Practice in the Russian Federation" approved by Order of the Ministry of Health of the Russian Federation No. 200n dated 01.04.2016. Informed consent to participate in the study was received from each of the surveyed, approved in accordance with the established procedure by the local ethics committee of Izmerov Research Institute of Occupational Health (minutes of the meeting of the Ethics committee of Izmerov Research Institute of Occupational Health No. 4 dated 12/25/2013).
Introduction. With the growth of urbanization processes, the problem of professional exposure to electric and magnetic fields of industrial frequency is an increasingly relevant topic. Recently, the scientists paid a special attention to the long-term health consequences associated with prolonged exposure to harmful physical factors. The previously obtained data on the increase in the levels of lipid metabolism and hormonal and metabolic disorders in workers exposed to electric and magnetic fields of industrial frequency determine the relevance of studying adipokine metabolism and assessing genetic risk factors for predisposition to cardiovascular pathology in employees of the electric power industry. The study aims to research the relationship of biochemical and molecular genetic markers of adipokine metabolism with indicators of hormonal and metabolic disorders for a comprehensive assessment of cardiovascular risk in workers exposed to electric and magnetic fields of industrial frequency. Materials and methods. The researchers examined 144 employees of the main group engaged in the repair and operation of power grid facilities and 40 employees of the control group who are not exposed to electromagnetic fields of industrial frequency.The concentration of leptin and adiponectin was determined in blood serum samples. The authors have calculated the ratio of adiponectin to leptin. We have performed a molecular genetic study of single nucleotide polymorphisms of leptin (LEP) G2548A (rs7799039), leptin receptor (LEPR) A668G (rs1137101) and adiponectin type two receptor (ADIPOR2) G795A (rs16928751) genes. Results. The staff of the main group revealed a higher level of leptin (8.1 (3.7; 14.4) ng/ml) relative to the same indicator in the control group (6.0 (4.1; 11.1) ng/ml), p<0.028. Levels of leptin and adiponectin moderately and weakly correlate with hormonal and metabolic parameters. In the group of employees with less than 10 years of experience, a higher level of adiponectin was established compared to the group with 11–20 years of experience (6.1 (4.6; 9.1) mcg/ml and 4.5 (3.6; 6.4) mcg/ml, respectively); with an increase in work experience of more than 20 years, a significant increase in the concentration of leptin was found (p<0.05). Scientists have identified the significance of single-nucleotide polymorphisms of the LEPR, LEP, ADIPOR2 genes in the development of abdominal obesity, an increase in cholesterol levels and a decrease in the level of total testosterone in workers exposed to electric and magnetic fields of industrial frequency. Limitations. The study is limited to the number of surveyed (144 employees). Conclusion. The results of the study indicate the relationship of biochemical and molecular genetic markers of adipokine metabolism with indicators of hormonal and metabolic disorders in employees exposed to electric and magnetic fields of industrial frequency. When examining workers exposed to electric and magnetic fields of industrial frequency, the use of clinical and laboratory markers of adipokine metabolism (biochemical, molecular genetic) is informative in a comprehensive assessment of cardiovascular risk. Ethics. The work complies with ethical standards developed in accordance with the Helsinki Declaration of the World Medical Association "Ethical Principles of conducting Scientific medical research with human participation" as amended in 2000 and the "Rules of Clinical Practice in the Russian Federation" approved by Order of the Ministry of Health of the Russian Federation No. 200n dated 01.04.2016. Informed consent to participate in the study was received from each of the surveyed, approved in accordance with the established procedure by the local ethics committee of Izmerov Research Institute of Occupational Health (minutes of the meeting of the Ethics committee of Izmerov Research Institute of Occupational Health No. 4 dated 12/25/2013).
Introduction. The article discusses the features of nutrition and the formation of the metabolic syndrome in workers in dust-hazardous industries. The relevance and urgency of studying the relation of nutrition to the development of obesity, arterial hypertension, impaired carbohydrate and lipid metabolism is due to the steady progression of the prevalence of metabolic syndrome both in the population as a whole and among workers in hazardous industries. The purpose. Hygienic assessment of the actual nutrition in different age groups from the standpoint of the risk of developing metabolic syndrome in workers of the industrial enterprises. Materials and methods. Sixty four workers aged of 51.0±8.7 years, the average work experience being 18.4±6.9 years were surveyed in the mining and engineering industries,. The ones surveyed were divided into two groups taking into account their age: the first group included people from 30 to 44 years (28 people), the second group included people aged 45 to 60 years (36 ones). The research methods included the assessment of actual nutrition, anthropometry, measurement of blood pressure, clarification of the glycemic profile and lipid spectrum. Results. The actual nutrition of workers in hazardous industries was found to be off-balanced in terms of macronutrient intake. In the age group of 30-44 years, a significant increase in the risk of developing metabolic syndrome was determined due to alcohol consumption, exceeding the norm of added sugar. In the older group (45-60 years), the risk of developing metabolic syndrome increased due to the excessive amount of total fats in the diet and a deficiency of dietary fibers. Limitations. The study included 64 workers aged 30 to 60 years, the correlation analysis of the compared indicators was carried out using a quantitative scale, when calculating the odds ratio, the indicators were measured on a nominal scale. Conclusion. There are revealed age-related features of actual nutrition of workers in dust-hazardous occupations, resulting in the development of abdominal obesity and metabolic syndrome, requiring further study to develop effective measures for the nutritional prevention of cardiovascular diseases and type 2 diabetes mellitus.
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