Metabolic Syndrome in Neuromuscular Disease

Aitkens, Susan G.; Kilmer, David D.; Wright, Nancy C.; McCrory, Megan A.

doi:10.1016/j.apmr.2004.09.012

Cited by 62 publications

(71 citation statements)

References 36 publications

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“…Rendeli et al also reported no significant differences in lipid profiles between SB children and adolescents (ages 1-16 y) and able-bodied controls (79). The trend towards decreased HDL and increased TG observed in our spinal cord dysfunction groups agrees with the results found in adult neuromuscular disease patients by Aitkens and colleagues (80). A higher proportion of their disabled group had decreased HDL and increased systolic blood pressure (80).…”

Section: Discussionsupporting

confidence: 80%

“…The trend towards decreased HDL and increased TG observed in our spinal cord dysfunction groups agrees with the results found in adult neuromuscular disease patients by Aitkens and colleagues (80). A higher proportion of their disabled group had decreased HDL and increased systolic blood pressure (80). They identified decreased HDL, increased BMI, and increased TG as the top 3 risk factors in both their disabled population and able-bodied control group.…”

Section: Discussionsupporting

confidence: 80%

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Metabolic Syndrome in Adolescents With Spinal Cord Dysfunction

Nelson

Widman

Abresch

et al. 2007

The Journal of Spinal Cord Medicine

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Objective: The purpose of this study was to determine the prevalence of components of the metabolic syndrome in adolescents with spinal cord injury (SCI) and spina bifida (SB), and their associations with obesity in subjects with and without SCI and SB.Methods: Fifty-four subjects (20 SCI and 34 SB) age 11 to 20 years with mobility impairments from lower extremity paraparesis were recruited from a hospital-based clinic. Sixty able-bodied subjects who were oversampled for obesity served as controls (CTRL). Subjects were categorized as obese if their percent trunk fat measured by dual x-ray absorptiometry (DXA) was .30.0% for males and .35.0% for females. Ten SCI, 24 SB, and 19 CTRL subjects were classified as obese. Fasting serum samples were collected to determine serum glucose, insulin, and lipid concentrations. Metabolic syndrome was defined as having !3 of the following components: (a) obesity; (b) high-density lipoprotein (HDL) ,45 mg/dL for males; ,50 mg/dL for females; (c) triglycerides !100 mg/dL; (d) systolic or diastolic blood pressure !95th percentile for age/ height/gender, and (e) insulin resistance determined by either fasting serum glucose 100-125 mg/dL; fasting insulin !20lU /mL; or homeostasis model assessment of insulin resistance !4.0.Results: Metabolic syndrome was identified in 32.4% of the SB group and 55% of the SCI group. Metabolic syndrome occurred at a significantly higher frequency in obese subjects (SB ¼ 45.8%, SCI ¼ 100%, CTRL ¼ 63.2%) than nonobese subjects (SB ¼ 0%, SCI ¼ 10%, CTRL ¼ 2.4%). Conclusions:The prevalence of metabolic syndrome in adolescents with SB/SCI is quite high, particularly in obese individuals. These findings have important implications due to the known risks of cardiovascular diseases and diabetes mellitus associated with metabolic syndrome in adults, particularly those with spinal cord dysfunction.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 80%

Metabolic Syndrome in Adolescents With Spinal Cord Dysfunction

Nelson

Widman

Abresch

et al. 2007

The Journal of Spinal Cord Medicine

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“…Moreover, it has been suggested that obesity in NMD patients leads to a high risk of developing chronic diseases. 3 In fact, myotonic dystrophy is thought to be associated with features of the metabolic syndrome, including insulin resistance, increased body fat mass, and hypertriglyceridemia. [3][4][5][6] Body mass index (BMI) has been widely used to screen for overweight in otherwise able-bodied subjects.…”

Section: Muscle Nerve 44: 503-508 2011mentioning

confidence: 99%

Regional body composition and functional impairment in patients with myotonic dystrophy

et al. 2011

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“…Although no studies have been performed on the body composition of PPS patients, patients with neuromuscular diseases have been reported to have reduced muscle mass and increased fat mass compared to healthy individuals [23][24][25] . This reduction of muscle mass is a consequence of disease-related disabilities that induce a sedentary life, which occurs without a reduction in food intake.…”

Section: Body Compositionmentioning

confidence: 99%

Basal Metabolic Rate and Body Composition in Patients with Post-Polio Syndrome

Bargieri¹,

Quadros²,

Pereira³

et al. 2008

Ann Nutr Metab

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The aim of this study was to compare basal metabolic rate (BMR) of post-polio syndrome (PPS) patients with healthy individuals and to determine its correlation to body composition. BMR (kcal/day) was determined by indirect calorimetry and body composition by dual energy X-ray absorptiometry. BMR was lower in the PPS patient group than in the control group, although it was similar in both groups when adjusted for body surface area, total body mass (TBM), lean body mass (LBM) and fat-free mass (FFM). PPS patients also showed reduced TBM, LBM and FFM in relation to controls. As muscle energy expenditure while at rest contributes only 20% to the BMR, a proportional reduction in BMR and FFM or LBM could suggest that muscle mass or other factors may interfere more than predicted. It was concluded that the prediction of BMR from the Harris-Benedict equation in PPS patients must be carefully reviewed.

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Metabolic Syndrome in Neuromuscular Disease

Cited by 62 publications

References 36 publications

Metabolic Syndrome in Adolescents With Spinal Cord Dysfunction

Metabolic Syndrome in Adolescents With Spinal Cord Dysfunction

Regional body composition and functional impairment in patients with myotonic dystrophy

Basal Metabolic Rate and Body Composition in Patients with Post-Polio Syndrome

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