Metabolic syndrome in drug-naïve patients with Depressive Disorders

Grover, Sandeep; Nebhinani, Naresh; Chakrabarti, Subho; Kulhara, Parmanand

doi:10.4103/0253-7176.116247

Cited by 13 publications

(11 citation statements)

References 40 publications

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“…Overall, we identified 31 eligible studies for inclusion in this meta‐analysis (Tables S3 and S4) (Arranz et al, ; Basoglu et al, ; Cai et al, ; Canan et al, ; Chang et al, ; Chen et al, ; Chen et al, ; Dasgupta, Singh, Rout, Saha, & Mandal, ; Enez Darcin, Yalcin Cavus, Dilbaz, Kaya, & Dogan, ; Fernandez‐Egea et al, ; Garcia‐Rizo et al, ; Garcia‐Rizo et al, ; Grover, Nebhinani, Chakrabarti, Avasthi, & Kulhara, ; Kavzoglu & Hariri, ; Keinanen et al, ; Leo et al, ; Misiak et al, ; Nyboe, Vestergaard, Moeller, Lund, & Videbech, ; Petrikis et al, ; Ryan et al, ; Saddichha, Manjunatha, Ameen, & Akhtar, ; Saloojee, Burns, & Motala, ; Sengupta et al, ; Spelman et al, ; Turan, Kesebir, & Suner, ; van Nimwegen et al, ; Venkatasubramanian et al, ; Wani et al, ; Wu et al, ; Yildirim et al, ; Zhang et al, ). Of these studies, one was conducted with patients who had a first episode mania (Turan et al, ), five were conducted with patients who had first episode depression (Canan et al, ; Chang et al, ; Garcia‐Rizo et al, ; Grover et al, ; Leo et al, ) and one was conducted with patients who had first episode mania or depression (Garcia‐Rizo et al, ). Twenty‐four were conducted in patients with FEP (Arranz et al, ; Basoglu et al, ; Cai et al, ; Chen, Broqueres‐You, et al, ; Chen, Du, et al, ; Dasgupta et al, ; Enez Darcin et al, ; Fernandez‐Egea et al, ; Kavzoglu & Hariri, ; Keinanen et al, ; Misiak et al, ; Nyboe et al, ; Petrikis et al, ; Ryan et al, ; Saddichha et al, ; Saloojee et al, ; Sengupta et al, ...…”

Section: Resultsmentioning

confidence: 99%

“…For the fasting blood glucose analysis, 32 outcomes were extracted from 30 studies (Arranz et al, ; Basoglu et al, ; Cai et al, ; Canan et al, ; Chang et al, ; Chen, Broqueres‐You, et al, ; Chen, Du, et al, ; Dasgupta et al, ; Enez Darcin et al, ; Fernandez‐Egea et al, ; Garcia‐Rizo et al, ; Garcia‐Rizo et al, ; Grover et al, ; Kavzoglu & Hariri, ; Keinanen et al, ; Leo et al, ; Misiak et al, ; Nyboe et al, ; Petrikis et al, ; Ryan et al, ; Saddichha et al, ; Saloojee et al, ; Sengupta et al, ; Spelman et al, ; Turan et al, ; van Nimwegen et al, ; Venkatasubramanian et al, ; Wani et al, ; Wu et al, ; Yildirim et al, ; Zhang et al, ). In our overall analysis, there was no significant difference on fasting glucose levels between patient and control groups (ES = 0.10, CI = −0.03‐0.23).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

Küçükgöncü

Košir

Zhou

et al. 2018

Early Intervention Psych

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Aim: To compare the differences of glucose metabolism outcomes between treatment-naïve, patients with first episode psychosis (FEP) and mood disorders.Methods: We conducted a systematic review and meta-analysis of glucose intolerance in treatment-naïve, first episode patients with severe mental illnesses (SMIs). Results:We identified 31 eligible studies. Compared to healthy controls, FEP group have higher insulin and insulin resistance levels, and both groups have higher glucose tolerance test results.No significant differences were found in glucose metabolism outcomes between FEP and mood disorder groups.Conclusions: Our results highlight impaired glucose metabolism at the onset of SMIs, suggesting both patients with psychosis and mood disorders are high-risk groups for diabetes development. K E Y W O R D Sdiabetes, first episode, insulin, mood disorders, psychosis

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

Küçükgöncü

Košir

Zhou

et al. 2018

Early Intervention Psych

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“…[19] This is comparable to the prevalence found in our patients group (26% in recurrent depression and 24% in bipolar depression group). In another study done on drug-naive patients[37] of depression in India, the prevalence of MetS was found to be significantly higher (37.2%) than healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…This has been reported in many of the studies. [243741424344] Over the last 10–15 years, an increasing amount of literature has appeared, examining the cross-sectional and longitudinal relationship between the constructs of obesity and depression. While a large number of these studies have defined obesity by BMI, which is an indicator of general fat distribution.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and central obesity in depression: A cross-sectional study

Agarwal

Garg

et al. 2016

Indian J Psychiatry

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Introduction:The current epidemiological data and meta-analyses indicate a bidirectional association between depression and metabolic syndrome (MetS).Aims:To assess the prevalence of metabolic syndrome and obesity in drug naïve patients (in current episode) having Recurrent Major Depressive Disorder and Bipolar Depression.Method:This was a single point cross sectional observational study that involved administration of diagnostic and assessment tools and blood investigations. Recruitment for the study was done from a period of September 2008 to august 2009.Results:The prevalence of MetS was significantly more in the depression group when compared to healthy controls. The Bipolar depression group had 24% prevalence and recurrent depression group had 26% prevalence as opposed to none in the control group. The prevalence of MetS did not differ significantly amongst the both depression groups. Presence of central obesity was significantly more in the recurrent depression (30%) and Bipolar depression (24%) as compared to controls (8%). There was no statistically significant difference between the two depression subgroups.Discussion:Our study adds to the mounting evidence that links the presence of depression and metabolic syndrome. As we had ensured a drug free period of at least 3 months, the findings in our study indicate that the metabolic syndrome observed in our study is independent of drug exposure.Conclusions:This study demonstrated significantly more incidence of metabolic syndrome and central obesity in patients of depression than age and sex matched controls.

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“…There was a weak association between depression and low high-density lipoprotein cholesterol, but not with other component criteria of the metabolic syndrome (Foley DL et al, 2010). 26 Among Indian studies one crosssectional study found 37% of the depressed patients had MS, wherein their age, sex matched healthy counterparts' prevalence of MS was 16.3% and this difference was significant (Grover S et al, 2013). 27 Among our patients 16(31.4%) had metabolic syndrome, whereas in controls it was 8 (17.4%).…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Prevalence of Metabolic Syndrome in Depressed Patients Attending a Tertiary Care Centre in Eastern India

Chattopadhyay¹,

Bhattacharya²,

Roy³

et al. 2018

jemds

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BACKGROUND Metabolic syndrome (MS) is rampant all over the world. Depression is expected to be the second most common cause of loss of DALY (Disability Adjusted Life Events) by 2020 after coronary artery disease as per WHO (World Health Organization). Previous studies show connection between depression and MS. Most studies are from western world. We tried to find MS in clinically depressed patients attending a tertiary care hospital of Eastern India. Aims and Objectives-Our objective was to assess the prevalence of MS in patients with depression who had never been treated with antidepressants for their depressive disorder and compare the same with a matched group of healthy patients. We followed the criteria proposed by the International Diabetes Federation (IDF) in diagnosing MS. MATERIALS AND METHODS There are two groups. Study group (51) comprised clinically depressed patients as per ICD-10. Second group comprised healthy controls (46) who were matched for age, sex, gender, education and socioeconomic profile. Anthropometric measurement and assessment of metabolic parameters were noted in both groups. Cases were given 'Beck Depressive Inventory (BDI)' to assess severity of depression. RESULTS 31.4% of study group and 17.4% of control group had MS. Most common of MS among study group was low HDL and among control group was central obesity. CONCLUSION Our study strongly indicates association of depression and MS. Low HDL was the most common abnormality in our patient group, in which females were more in number.

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Metabolic syndrome in drug-naïve patients with Depressive Disorders

Cited by 13 publications

References 40 publications

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

Metabolic syndrome and central obesity in depression: A cross-sectional study

Comparative Study of Prevalence of Metabolic Syndrome in Depressed Patients Attending a Tertiary Care Centre in Eastern India

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