Metabolic syndrome – From the neurotrophic hypothesis to a theory

Hristova, Mariyana G.

doi:10.1016/j.mehy.2013.07.018

Cited by 34 publications

(38 citation statements)

References 150 publications

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“…The increase in TNF-α and IL-6 serum levels in MetS also play a role in the pathogenesis in psoriasis patients (2)(3)(4)(5)(6)(7)29). TNF-α and IL-6 serum and tissue levels were similar in all three groups in our study.…”

Section: Discussionsupporting

confidence: 64%

“…Recent studies have suggested that chronic inflammation plays an important role in the development of MetS and obesity, and neurotrophins are thought to be one of the factors in the pathogenesis of this inflammation (6). BDNF and NGF were reported to be associated with diabetes and cardiometabolic risk factors in addition to their neurological effects (7,12,(14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

“…The neurotrophins (NTs) are composed of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), NT-3, NT-4 and NT-5 and are believed to be associated with inflammatory diseases as well as MetS (4,5). In recent studies, NTs have been reported to be effective not only on the peripheral and central nervous system but also on the immune and endocrine systems (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…BDNF is a recently identified NT, and responsible for the regulation of synaptic activities and development of neurons (6,(9)(10)(11)(12). Besides, it has been shown to be associated with lipid level elevation and to be a potential marker for the peripheral inflammatory response (6).…”

Section: Introductionmentioning

confidence: 99%

“…Besides, it has been shown to be associated with lipid level elevation and to be a potential marker for the peripheral inflammatory response (6).…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the Role of Neurotrophins in the Psoriasis and Metabolic Syndrome Relationship

Bulur¹,

Erdoğan²,

Çiftçi³

et al. 2017

tdd

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ÖzAmaç: Psoriasis hastalarında ve sağlıklı kontrollerde serum ve deri örneklerinde beyin türevli nörotrofik faktör (BDNF), sinir büyüme faktörü (NGF), tümör nekroz faktör-α (TNF) ve interlökin-6 (IL) düzeylerini belirleyerek metabolik sendrom (MetS) ve psoriasis ilişkisinde nörotrofinlerin yerini değerlendirmeyi amaçladık. Yöntemler: Serum BDNF, NGF, TNF-α ve IL-6 düzeyleri ticari hazır ELISA kitleri ile değerlendirildi. BDNF, NGF, TNF-α ve IL-6 antikorları ile BDNF, NGF, TNF-α ve IL-6'nın derideki ekspresyon düzeyi belirlendi. Bulgular: MetS risk faktörlerinden herhangi birinin eşlik etmediği 39 psoriasis vulgaris hastası, MetS'nin eşlik ettiği 21 psoriasis vulgaris hastası ile 15 sağlıklı kontrol çalışmaya dahil edildi. BDNF'nin serum, epidermal ve dermal infiltrasyon düzeyi kontrol grubunda psoriasis hastalarına göre belirgin olarak yüksek saptandı (p=0,017; p=0,019; p=0,002). Serum NGF, TNF-α ve IL-6 düzeyleri açısından gruplar arasında farklılık saptanmaz iken (p˃0,05), psoriasis hastalarında epidermiste NGF'nin infiltrasyon düzeyi kontrol grubuna göre daha fazla olup istatistiksel olarak anlamlı fark tespit edildi (p=0,003). Psoriasis hasta grupları arasında ise serum BDNF düzeyi, epidermal ve dermal BDNF infiltrasyon düzeyi ve epidermal NGF infiltrasyon düzeyi ise benzerdi (p>0,05). Sonuç: Çalışmamızdaki sonuçlar nörotrofinlerin psoriasis patogenezindeki yerini desteklemektedir. Ancak çalışmamızda psoriasis grupları arasında serum ve doku BDNF, NGF düzeylerinin değişmemiş olması, psoriasis immünopatogenezinde nörotrofinlerin metabolik durumdan bağımsız olarak inflamatuvar süreç ile ilişkili olduğunu düşündürmüştür. Anahtar kelimeler: Beyin türevli nörotrofik faktör, sinir büyüme faktörü, nörotrofin, metabolik sendrom, psoriasis, immünopatogenez Objective: We aimed to evaluate the role of neurotrophins in relation to metabolic syndrome (MetS) and psoriasis by determining brain derived neurotrophic hormon (BDNF), nerve growth factor (NGF), tumor necrosis factor-α (TNF) and interleukin-6 (IL) levels in serum and skin samples of psoriasis patients and healthy controls. Methods: The BDNF, NGF, TNF-α and IL-6 levels were assessed using commercially available ELISA kits. The level of expression BDNF, NGF, TNF-α and IL-6 antibodies was determined by BDNF, NGF, TNF-α and IL-6 Antibodies. Results: Thirty nine psoriasis vulgaris patients without MetS risk factors, 21 patients with psoriasis vulgaris accompanied by MetS and 15 healthy controls were included in the study. The serum BDNF levels, epidermal and the dermal infiltration levels of BDNF were significantly higher in the control group than in the psoriasis patients (p=0.017, p=0.019, p=0.002). There was no difference between the groups in terms of serum NGF, TNF-α and IL-6 levels (p˃0.05), but the infiltration level of NGF in the epidermis was higher in the psoriasis patients than the control group and statistically significant difference was found (p=0.003). Serum BDNF levels, epidermal and dermal BDNF infiltration level and the epidermal NGF stainin...

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Besides, it has been shown to be associated with lipid level elevation and to be a potential marker for the peripheral inflammatory response (6).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluating the Role of Neurotrophins in the Psoriasis and Metabolic Syndrome Relationship

Bulur¹,

Erdoğan²,

Çiftçi³

et al. 2017

tdd

View full text Add to dashboard Cite

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At the Crossroad Between Obesity and Gastric Cancer

Garai

Uddo

Mohler

et al. 2014

Methods in Molecular Biology

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Obesity has reached epidemic proportions worldwide with disproportionate prevalence in different communities and ethnic groups. Recently, the American Medical Association recognized obesity as a disease, which is a significant milestone that opens the possibilities of treating obesity under standardized health plans. Obesity is an inflammatory disease characterized by elevated levels of biomarkers associated with abnormal lipid profiles, glucose levels, and blood pressure that lead to the onset of metabolic syndrome. Interestingly, inflammatory biomarkers, in particular, have been implicated in the risk of developing several types of cancer. Likewise, obesity has been linked to esophageal, breast, gallbladder, kidney, pancreatic, and colorectal cancers. Thus, there exists a link between obesity status and tumor appearance, which may be associated to the differential levels and the circulating profiles of several inflammatory molecules. For example, mediators of the inflammatory responses in both obesity and gastric cancer risk are the same: pro-inflammatory molecules produced by the activated cells infiltrating the inflamed tissues. These molecules trigger pathways of activation shared by obesity and cancer. Therefore, understanding how these different pathways are modulated would help reduce the impact that both diseases, and their concomitant existence, have on society.

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