Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: The Northern Manhattan Study (NOMAS)

Suzuki, Takeki; Hirata, Kumiko; Elkind, Mitchell S.V.; Jin, Zhezhen; Rundek, Tatjana; Miyake, Yumiko; Boden‐Albala, Bernadette; Tullio, Marco R. Di; Sacco, Ralph L.; Homma, Shunichi

doi:10.1016/j.ahj.2008.02.022

Cited by 132 publications

(117 citation statements)

References 38 publications

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“…27 Flowmediated dilatation has been independently and negatively associated with the area-under-the-curve for glucose in antepartum oral glucose tolerance tests. 27 Considering that endothelial dysfunction is predictive of both future type 2 diabetes and cardiovascular disease, 28,29 these data are consistent with the hypothesis that antepartum glucose intolerance is linked to both of these outcomes.…”

Section: Discussionsupporting

confidence: 75%

Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study

Retnakaran

Shah²

2009

Canadian Medical Association Journal

169

118

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Section: Discussionsupporting

confidence: 75%

Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study

Retnakaran

Shah²

2009

Canadian Medical Association Journal

169

118

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“…11 In our study, the rate of endothelial dysfunction was 63.08% and 28.57% in hypertensive and non-hypertensive subjects respectively (p = 0.01). Similarly, the rate of hypertension was 80.39% and 48.98% in subjects with and without endothelial dysfunction (p = 0.001).…”

Section: Discussionmentioning

confidence: 80%

“…10 ED, defined by a lower flow-mediated dilation (FMD) value, has been found to be associated with cardiovascular events. 11 The brachial-artery flow-mediated dilation (FMD) has been extensively used to identify the ED proposed as a surrogate marker of cardiovascular disease. 12,13,14 Studies have reported diverse association between HTN and ED.…”

Section: Introductionmentioning

confidence: 99%

Endothelial dysfunction and the role of hypertension in Nepalese subjects with major coronary risk factors

Gautam¹,

Gautam

Ghimire³

et al. 2016

Nepalese Heart J.

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Background and Aims: Hypertension is one of the major coronary heart disease risk factors. Endothelial dysfunction is thought to be the preclinical vascular changes in the pathogenesis of atherosclerosis and it its major manifestation; coronary heart disease. This study was designed to assess the endothelial function in subjects with major coronary risk factors including hypertension.Methods: The study was conducted in a tertiary referral centre in Central Nepal. A cross-sectional study was conducted on the cohort of 100 subjects with at least one out of six major coronary heart disease risk factors. JNC 7 criteria were used to define hypertension. Brachial artery flow-mediated dilation was measured using high-resolution ultrasound. Endothelial dysfunction was defined as flow-mediated dilation value <9.99%. The association between endothelial dysfunction and hypertension was assessed by univariate and multivariate analysis.Results: Out of 100 subjects with coronary risk factors (mean age 46.75±9.95 years, mean number of risk factors 2.81± 1.17), 65% subjects were hypertensive and 35% were non-hypertensive. Hypertension as a risk factor was evident in 80.39% and 48.98% subjects with abnormal and normal endothelial response respectively (p = 0.001). In addition, 63.08% and 28.57% subjects with and without hypertension had endothelial dysfunction respectively (p=0.01). Hypertension was the only coronary risk factor associated with endothelial dysfunction in a multivariate model (p=0.04).Conclusion: Hypertension was strongly associated with endothelial dysfunction and it could be the best predictor of endothelial dysfunction and subsequent coronary heart disease in coronary heart diseases risk factor cohorts.Nepalese Heart Journal 2016; 13(1): 13-18

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“…As well as hyperlipidemia, inflammation is a major risk factor of atherosclerosis. Several inflammatory biomarkers, such as hsCRP, cytokines, and biomarkers of endothelial cell activation, have been investigated by other research groups (5,6).…”

Section: Introductionmentioning

confidence: 99%

The functional and compositional properties of lipoproteins are altered in patients with metabolic syndrome with increased cholesteryl ester transfer protein activity

Park

Shin²,

Kim³

et al. 2009

Int J Mol Med

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Abstract.To compare the molecular composition and functional differences at the lipoprotein level, we analyzed individual lipoprotein fractions from male patients with metabolic syndrome (MetS) (n=10) and gender-and age-matched healthy controls (n=14). The MetS group had significantly higher obesity, blood pressure, serum cholesterol, triglyceride (TG), adiponectin, and uric acid levels than the control group, while the serum blood urea nitrogen and creatinine levels of the MetS group were in the normal range. The MetS group had much weaker serum antioxidant ability and were more susceptible to coppermediated low-density lipoprotein (LDL)-oxidation. TG and apoC-III co-accumulated with LDL, high density lipoprotein (HDL) 2 , and HDL 3 in the MetS group. The MetS group had serum amyloid A (SAA)-enriched HDL 2 and HDL 3 , although the serum level of SAA was not higher than in controls. The MetS group had significantly deprived paraoxonase (PON) activity in the serum and HDL, while the MetS group had 38% higher serum cholesteryl ester transfer protein (CETP) activity than that of the control group. Many serum parameters, such as TG, apoC-III, and uric acid, were elevated in the MetS group, and most of these measures were enriched in the LDL and HDL fractions rather than the very low density lipoprotein (VLDL) fraction. The lipid and apolipoprotein composition of HDL was severely altered and its beneficial functions were severely diminished. ApoA-I level was more readily detected in lipoprotein-deficient serum of the MetS group, indicating that the apoA-I exists in a lipid-free state. These results suggest that the MetS group had dysfunctional HDL that enriched TG, apoC-III, CETP, and SAA without antioxidant activity.

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Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: The Northern Manhattan Study (NOMAS)

Abstract: Metabolic syndrome is associated with incident cardiovascular events. Combined use of MetS and FMD identifies those who are at higher risk of cardiovascular events. Metabolic syndrome and noninvasive FMD testing can be used concurrently for cardiovascular risk prediction.

Cited by 132 publications

References 38 publications

Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study

Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study

Endothelial dysfunction and the role of hypertension in Nepalese subjects with major coronary risk factors

The functional and compositional properties of lipoproteins are altered in patients with metabolic syndrome with increased cholesteryl ester transfer protein activity

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