Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism

Iqbal, Jahangir; Qarni, Ali Al; Hawwari, Abbas; Alghanem, Ahmad F.; Gasmelseed, Ahmed

doi:10.2174/1573399813666170705161039

Cited by 74 publications

(51 citation statements)

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“…In addition, the consumption of green tea has been shown to inhibit atherosclerosis, reduce total lipid levels, and improve the ratio of LDL to HDL [ 16 , 17 ]. Diabetes and obesity are closely associated with a spectrum of disorders known as metabolic syndrome (MetS) which includes increased waist diameter, elevated plasma triglycerides, decreased HDL, increased fasting blood glucose, and elevated blood pressure [ 18 , 19 ]. Type 2 diabetes is also associated with insulin resistance and sometimes decreased insulin production.…”

Section: Introductionmentioning

confidence: 99%

Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

Reygaert

2018

BioMed Research International

213

144

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Green tea is one of the most popular drinks consumed worldwide. Produced mainly in Asian countries from the leaves of the Camellia sinensis plant, the potential health benefits have been widely studied. Recently, researchers have studied the ability of green tea to eradicate infectious agents and the ability to actually prevent infections. The important components in green tea that show antimicrobial properties are the catechins. The four main catechins that occur in green tea are (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG). Of these catechins, EGCG and EGC are found in the highest amounts in green tea and have been the subject of most of the studies. These catechins have been shown to demonstrate a variety of antimicrobial properties, both to organisms affected and in mechanisms used. Consumption of green tea has been shown to distribute these compounds and/or their metabolites throughout the body, which allows for not only the possibility of treatment of infections but also the prevention of infections.

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Section: Introductionmentioning

confidence: 99%

Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

Reygaert

2018

BioMed Research International

213

144

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“…Additionally, increased flux of FFA to the liver in the insulin resistant state stimulates production TG and secretion in the form of very-low-density lipoprotein (VLDL). The resulting hypertriglyceridemia leads to lower HDL‐C levels and normal or slightly elevated low-density lipoprotein-cholesterol (LDL-C) levels ( Iqbal et al., 2018 ). This is related to the typical dyslipidemic profile in MetS.…”

Section: Pathogenesis Of Metsmentioning

confidence: 99%

The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review

Salazar-Gómez

Ontiveros-Rodríguez

Pablo-Pérez

et al. 2020

South African Journal of Botany

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Highlights Definition and pathogenesis of metabolic syndrome is briefly described. Sesquiterpene lactones isolated from medicinal plants used in traditional medicine. In vivo and in vitro biological activities of sesquiterpene lactones are considered. Chemical and biological properties of natural sesquiterpene lactones are documented.

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“…High-fat or high-cholesterol diet plays a significant role in the pathogenesis of AS. Several studies have shown that dyslipidemia is an important risk factor for various cardiovascular diseases, characterized by decrease in plasma highdensity lipoprotein (HDL) cholesterol, and increase in plasma triglyceride, low-density lipoprotein (LDL) cholesterol, and total cholesterol (TC) [1]. Among these lipids, LDL has a pivotal role and is a predictive marker of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats

Wang

Zheng

et al. 2020

Med Sci Monit

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Background: The purpose of the present study was to evaluate the regulatory effects of acetyl-L-carnitine (ALCAR) on atherosclerosis in Wister rats and to explore its anti-atherosclerotic mechanism. Material/Methods: We randomly divided 32 Wister rats into 4 groups: a normal diet group (control group, n=8), a normal diet+ALCAR group (ALCAR group, n=8), an atherosclerosis group (AS group, n=8), and an atherosclerosis+ALCAR group (AS+ALCAR group, n=8). The serum lipid distribution, oxidative stress, inflammatory factors and adiponectin (APN) in the blood, and heart and aortic tissues were determined using the standard assay kits, xanthine oxidase method, and ELISA, respectively. HE staining was performed to observe aortic pathology structure change, and the level of angiotensin II (AngII) in the aorta was assessed using radioimmunoassay. In addition, real-time quantitative PCR and Western blot analysis were applied to detect the expression of iNOS, IL-1b, TNF-a, and CRP in the aortic and heart tissues. Results: Compared with the AS group, the levels of serum TC, TG, LDL, and VLDL in rats decreased significantly, while HDL level significantly increased in the AS+ALCAR group. ALCAR administration enhanced the SOD and GSH-Px activities and decreased MDA activity. APN level was significantly elevated in the AS group, but ALCAR had no significant effect on APN. Further, ALCAR reduced the expressions of inflammation factors TNF-a, IL-1b, iNOS, and CRP, and the concentration of AngII in serum, aortic, and heart tissues. Conclusions: ALCAR can inhibit the expressions of inflammatory factors and antioxidation to suppress the development of atherosclerosis by adjusting blood lipid in the myocardium of AS rats.

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Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism

Abstract: In the current review, we have discussed the pathophysiology of lipoprotein biosynthesis and metabolism in the metabolic syndrome. Finally, we describe regulation of lipoprotein metabolism which may be used as a potential target for treating dyslipidemia in metabolic syndrome.

Cited by 74 publications

References 0 publications

Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review

Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats

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