Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

Reygaert, Wanda

doi:10.1155/2018/9105261

Cited by 214 publications

(157 citation statements)

References 104 publications

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“…Stem cells, or precursor cells, are characterized by the ability to proliferate, i.e., self-renew, and maintain a constant, unchanging number of cells; they also have the ability to differentiate into an appropriate cell type. Notably, green tea extract and EGCG inhibit cell growth in these cellular and animal models [42,43].…”

Section: Anticancer Potential Of Green Tea Catechins Based On In Vitrmentioning

confidence: 99%

Beneficial Properties of Green Tea Catechins

Musiał

Kuban–Jankowska

Górska‐Ponikowska

2020

IJMS

397

250

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Green tea (Camellia sinesis) is widely known for its anticancer and anti-inflammatory properties. Among the biologically active compounds contained in Camellia sinesis, the main antioxidant agents are catechins. Recent scientific research indicates that the number of hydroxyl groups and the presence of characteristic structural groups have a major impact on the antioxidant activity of catechins. The best source of these compounds is unfermented green tea. Depending on the type and origin of green tea leaves, their antioxidant properties may be uneven. Catechins exhibit the strong property of neutralizing reactive oxygen and nitrogen species. The group of green tea catechin derivatives includes: epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate. The last of these presents the most potent anti-inflammatory and anticancer potential. Notably, green tea catechins are widely described to be efficient in the prevention of lung cancer, breast cancer, esophageal cancer, stomach cancer, liver cancer and prostate cancer. The current review aims to summarize the potential anticancer effects and molecular signaling pathways of major green tea catechins. It needs to be clearly emphasized that green tea as well as green tea catechols cannot replace the standard chemotherapy. Nonetheless, their beneficial effects may support the standard anticancer approach.

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Section: Anticancer Potential Of Green Tea Catechins Based On In Vitrmentioning

confidence: 99%

Beneficial Properties of Green Tea Catechins

Musiał

Kuban–Jankowska

Górska‐Ponikowska

2020

IJMS

397

250

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“…Dark teas undergo high oxidation levels, whereas green tea completely skips oxidation, avoiding the browning process and thus preserving the green color of the leaf matrix and its richness in bioactive polyphenols. Catechins comprise 80-90% of flavonoid content [4], and they are especially pointed out as green tea (GT) catechins, as flavan-3-ols in GT mostly show a galloyl moiety on the C-3 carbon of catechin core or a pyrogallol B-ring. Catechins are nutraceutical compounds, exerting a preventive efficacy in offsetting oxidant species over-genesis in normal cells, and for their ability to halt or reverse oxidative stress-related diseases [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Coumaroyl Flavonol Glycosides and More in Marketed Green Teas: An Intrinsic Value beyond Much-Lauded Catechins

et al. 2020

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Marketed green teas (GTs) can highly vary in their chemical composition, due to different origins, processing methods, and a lack of standardization of GT-based products. Consequently, biological activities become difficult to correlate to the presence/content of certain constituents. Herein, ultra-high-performance liquid chromatography (UHPLC) combined with high-resolution tandem mass spectrometry (HR MS/MS) was successfully applied to six commercial GT products, extracted by ethanol sonication, to disclose their polyphenol profile beyond the well-known catechins. The relative abundance of each class of metabolites was correlated to antiradical and antilipoperoxidant data through hierarchical clustering analysis, since it reasonably affects the beneficial properties of the product that reaches the consumer. The thiobarbituric acid reactive substances (TBARS) assay demonstrated that GT extracts effectively counteracted the UV-induced lipoperoxidation of hemp oil, which is highly rich in Polyunsaturated Fatty Acids (PUFAs), and therefore highly unstable. The Relative Antioxidant Capacity Index (RACI) comprehensively emphasized that gunpower and blend in filter GTs appeared to be the less active matrices, and except for a GT-based supplement, the Sencha GT, which was particularly rich in flavonol glycosides, was the most active, followed by Bancha GT.

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“…Even when administered intravenously, catechins are partly degraded before they reach the target tissues (25). Catechins also undergo metabolic breakdown in the liver, small intestine, and colon (26). Several recent studies have described the anti-infective characteristics of the primary catechin of green tea leaves, epigallocatechin-3-gallate (EGCG).…”

Section: Catechinsmentioning

confidence: 99%

“…The antimicrobial activity of green tea catechins (GTCs) has been widely researched, and green tea has been shown to function synergistically with various antibiotics in many ways, directly and indirectly, against these pathogens. Antimicrobial activity can also be derived from the anti-inflammatory and antioxidant properties of green tea (26).…”

Section: Catechinsmentioning

confidence: 99%