“…Furthermore, equal weight toward the diagnosis of the metabolic syndrome is given to each criterion. After a couple of decades, Reaven himself questioned the clinical utility of metabolic syndrome as a diagnostic category (2), and some suggested that the time of metabolic syndrome as a condition has already passed (3). Nevertheless, much research on the diagnosis of metabolic syndrome is being published: up to January 23, 2017, 24,173 abstracts could be found on PubMed, when searching for the MeSH term "metabolic syndrome X".…”
“…Furthermore, equal weight toward the diagnosis of the metabolic syndrome is given to each criterion. After a couple of decades, Reaven himself questioned the clinical utility of metabolic syndrome as a diagnostic category (2), and some suggested that the time of metabolic syndrome as a condition has already passed (3). Nevertheless, much research on the diagnosis of metabolic syndrome is being published: up to January 23, 2017, 24,173 abstracts could be found on PubMed, when searching for the MeSH term "metabolic syndrome X".…”
“…One letter to this journal, commenting on the now famous merry-go-round editorial by Prof. Reaven, has optimistically stated that the creator had killed the creature (16).…”
“…Independente destes processos, as concentrações de colesterol intracelular são fundamentais para a homeostase corpórea de colesterol, uma vez que regulam diretamente a expressão do LDLR e sua síntese de novo 42 . A partícula de LDL em excesso na circulação pode ser oxidada ou modificada 43 As partículas de HDL compõem a fração de lipoproteínas plasmáticas de menor tamanho e maior densidade; são bastante heterogêneas, podendo ser divididas em subfrações com propriedades metabólicas diferentes, de acordo com a sua composição, densidade, tamanho e mobilidade eletroforética 17,45,46 .…”
Section: European Atherosclerosis Society (Eas)unclassified
“…Em seguida, por ser extremamente hidrofóbico, o colesterol esterificado se desloca para o núcleo da partícula, mudando a conformação estrutural da HDL para uma partícula esférica 45,49 que continua participando da remoção de colesterol celular preferencialmente via transportador ABCG1 (do inglês, ATP binding cassette transporter G1) e receptor SR-BI (do inglês, scavenger receptor class B type I) 36,49 .…”
Section: European Atherosclerosis Society (Eas)unclassified
A ata de defesa com as respectivas assinaturas dos membros da banca examinadora encontra-se no processo de vida acadêmica do aluno.
Data: DATA DA DEFESA [29/08/2018] Aos meus pais, João (in memoriam) e Cristina, por todo o seu amor e confiança e ao meu marido Robson por todo amor e incentivo pelo meu crescimento.
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