Metabolic syndrome in children and teenagers: worth assessing it, but how?

Filho, Gilberto Da Paz

doi:10.1590/2359-3997000000249

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…In the pediatric population such conclusions are not clear. Due to both lack of long-term follow-up of pediatric patients and different criteria for MS, some authors suggest that the prevalence of individual components of metabolic syndrome in the pediatric population would be more relevant for assessment of the cardiovascular risk than the diagnosis of metabolic syndrome [ 38 , 39 ]. In the studied population, based on IDF criteria [ 19 ], 34 (31.48%) patients were diagnosed with MS, which is comparable to other studies using the same criteria (Strojny et al, 29% [ 40 ]).…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Adiposity Level, Metabolic Syndrome, and Insulin Resistance for the Risk of Nonalcoholic Fatty Liver Disease Diagnosis in Obese Children

Prokopowicz

Małecka-Tendera

Matusik

2018

Canadian Journal of Gastroenterology and Hepatology

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Background Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in obese children. Early diagnosis and treatment are essential for curing or slowing down the disease progression. The aim of the study was to assess the prevalence of NAFLD in this population and to identify anthropometrical and metabolic risk factors for NAFLD prediction and its development. Material and Methods The study included 108 obese children. Anthropometric measurements, NAFLD diagnosis (based on ALT level and/or liver ultrasound), and metabolic syndrome (MS) components were assessed in all patients. Patients were divided into groups with and without NAFLD. Results NAFLD was diagnosed in 49 (45%) patients with similar prevalence in boys (27; 55.10%) and girls [22 (44.9%), p = 0.089]. NAFLD patients had significantly greater waist circumference, WHR, and WHtR and significantly higher total cholesterol, triglyceride, and fasting insulin concentrations as well as higher glucose and insulin concentrations in 120 minutes of OGTT and higher HOMA-IR levels compared to group of patients without NAFLD. In NAFLD patients, MS was significantly more likely to be diagnosed than in group without NAFLD (40.82% versus 22.81%, p = 0.04), but among the MS components only hypertriglyceridemia was significantly more frequently diagnosed in the group with NAFLD (p = 0.002). Among analysed parameters the best independent risk factor for NAFLD was fasting insulin concentration with the cut-off point = 18,9 uIU/ml (AUC = 0.829). Conclusions NAFLD is a very common disease in obese children. NAFLD predictive risk factors include increased waist circumference, elevated WHR and WHtR, and elevated total cholesterol, triglycerides, and fasting insulin as well as elevated glucose and insulin concentration in the OGTT and HOMA-IR index. NAFLD increases the risk of potential cardiovascular complications expressed by diagnosis of metabolic syndrome. The best independent predictive risk factor for diagnosing NAFLD in obese children is fasting insulin > 18.9 uIU/ml.

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Section: Discussionmentioning

confidence: 99%

Predictive Value of Adiposity Level, Metabolic Syndrome, and Insulin Resistance for the Risk of Nonalcoholic Fatty Liver Disease Diagnosis in Obese Children

Prokopowicz

Małecka-Tendera

Matusik

2018

Canadian Journal of Gastroenterology and Hepatology

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“…Researchers emphasized that it differed significantly depending on the definition criteria applied and ranged from 6 to 39% [34]. Some authors suggest that the prevalence of individual components of MetS in the pediatric population would be more relevant for the assessment of cardiovascular risk than the diagnosis of MetS [35]. In 2005, Alberti et al proposed a global definition for MetS in adults.…”

Section: Definition Of Metabolic Syndrome In Children and Adolescentsmentioning

confidence: 99%

From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)—New Terminology in Pediatric Patients as a Step in Good Scientific Direction?

Flisiak-Jackiewicz

Bobrus-Chociej

Wasilewska

et al. 2021

JCM

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, which predispose to more serious hepatic conditions. It ranges from simple liver steatosis to nonalcoholic steatohepatitis (NASH), which may progress to cirrhosis, and even end-stage liver disease. Since obesity became one of the most important health concerns wordwide, a considerable increase in the prevalance of NAFLD and other metabolic implications has been observed, both in adults and children. Due to the coexistence of visceral obesity, insulin resistance, dyslipidemia, NAFLD is considered to be the hepatic manifestation of metabolic syndrome (MetS). These relationships between NAFLD and MetS led to the set up in adults of a new term combining both of these conditions, called metabolic dysfunction-associated fatty liver disease (MAFLD). Based on these findings, we propose a set of criteria, which may be useful to diagnose MAFLD in children and adolescents.

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“…Researchers emphasized that it differed significantly depending on the definition criteria applied and ranged from 6 to 39%[29]. Some authors suggest that the prevalence of individual components of MetS in the pediatric population would be more relevant for the assessment of cardiovascular risk than the diagnosis of MetS[30]. In 2005, Alberti et al proposed a global definition for MetS in adults.…”

mentioning

confidence: 99%

From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) – New Terminology in Pediatric Patients as a Step in Good Scientific Direction?

Flisiak-Jackiewicz¹,

Bobrus-Chociej²,

Wasilewska³

et al. 2021

Preprint

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, which predispose to more serious hepatic conditions. It ranges from simple liver steatosis to nonalcoholic steatohepatitis (NASH), which may progress to cirrhosis and even end-stage liver disease. Since obesity became one of the most important health concerns wordwide, a considerable increase in the prevalance of NAFLD and other metabolic implications has been observed, both in adults, and children. Due to the coexistence of visceral obesity, insulin resistance, dyslipidemia, NAFLD is considered to be the hepatic manifestation of metabolic syndrome (MetS). These relationship between NAFLD and MetS led to set up in adults new term combining both of these conditions, called metabolic dysfunction-associated fatty liver disease (MAFLD). Based of these findings, we propose set of criteria, which may be useful to diagnose MAFLD in children and adolescents.

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Metabolic syndrome in children and teenagers: worth assessing it, but how?

Cited by 5 publications

References 23 publications

Predictive Value of Adiposity Level, Metabolic Syndrome, and Insulin Resistance for the Risk of Nonalcoholic Fatty Liver Disease Diagnosis in Obese Children

Predictive Value of Adiposity Level, Metabolic Syndrome, and Insulin Resistance for the Risk of Nonalcoholic Fatty Liver Disease Diagnosis in Obese Children

From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)—New Terminology in Pediatric Patients as a Step in Good Scientific Direction?

From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) – New Terminology in Pediatric Patients as a Step in Good Scientific Direction?

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