Metabolic syndrome and lipid metabolism disorders: Molecular and biochemical aspects

Tkachenko, Oksana; Polishchuk, I I; Gorchakova, Nadiya; Zaychenko, Hanna

doi:10.5937/afmnai2001005t

Cited by 4 publications

(8 citation statements)

References 30 publications

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“…Obesity is basically provoked by an imbalance between the energy intake and expenditure, as mentioned above; this alteration leads to an enlargement of the white adipose tissue because of the accumulation of lipids, which also occurs in peripheral relevant organs [ 11 ]. This lipotoxic situation provokes a dysfunction in the adipose tissue that is linked to an altered lipid metabolism, impaired adipose tissue expandability and adipocyte hypertrophy [ 6 ]. Indeed, all these defects in the adipose tissue functions and the peripheral lipotoxicity are crucial in the beginning of the metabolic syndrome, and in the development of insulin resistance [ 6 ].…”

Section: Metabolic Diseasesmentioning

confidence: 99%

“…This lipotoxic situation provokes a dysfunction in the adipose tissue that is linked to an altered lipid metabolism, impaired adipose tissue expandability and adipocyte hypertrophy [ 6 ]. Indeed, all these defects in the adipose tissue functions and the peripheral lipotoxicity are crucial in the beginning of the metabolic syndrome, and in the development of insulin resistance [ 6 ]. At molecular level, changes in the adipose tissue are responsible for modifications in pathways related to the lipid metabolism (lipogenesis and lipolysis), as well as in hormones (leptin, adiponectin, etc.)…”

Section: Metabolic Diseasesmentioning

confidence: 99%

“…At molecular level, changes in the adipose tissue are responsible for modifications in pathways related to the lipid metabolism (lipogenesis and lipolysis), as well as in hormones (leptin, adiponectin, etc.) [ 6 , 11 , 15 ]. Moreover, an enhanced oxidative stress together with a chronic low-grade inflammation are present in obesity [ 5 , 6 ].…”

Section: Metabolic Diseasesmentioning

confidence: 99%

“…All together suggests that inflammation constitutes a main and common player in the development and progression of the above mentioned prominent metabolic diseases [ 2 , 3 , 4 , 5 , 6 ]. In addition, it should be considered that the relationship between immunity and metabolism is bidirectional and comprises both the role of inflammation in the pathogenesis of metabolic disorders and the effect of the metabolic state, including the inflammatory situation on the regulation of immune cells [ 7 , 8 ].…”

Section: Metabolic Diseasesmentioning

confidence: 99%

“…Indeed, the mentioned diseases are considered the most prevalent disorders worldwide [ 1 ]. Theses illnesses present a very different pathophysiology, but oxidative stress and inflammation are common key players involved in their development and progression [ 2 , 3 , 4 , 5 , 6 ]. Importantly, the metabolic state also influences immunity and inflammation, and it should be considered that these relations are bidirectional [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Dietary Flavanols on Microbiota, Immunity and Inflammation in Metabolic Diseases

Martín

Ramos

2021

Nutrients

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Flavanols are natural occurring polyphenols abundant in fruits and vegetables to which have been attributed to beneficial effects on health, and also against metabolic diseases, such as diabetes, obesity and metabolic syndrome. These positive properties have been associated to the modulation of different molecular pathways, and importantly, to the regulation of immunological reactions (pro-inflammatory cytokines, chemokines, adhesion molecules, nuclear factor-κB [NF-κB], inducible enzymes), and the activity of cells of the immune system. In addition, flavanols can modulate the composition and function of gut microbiome in a prebiotic-like manner, resulting in the positive regulation of metabolic pathways and immune responses, and reduction of low-grade chronic inflammation. Moreover, the biotransformation of flavanols by gut bacteria increases their bioavailability generating a number of metabolites with potential to affect human metabolism, including during metabolic diseases. However, the exact mechanisms by which flavanols act on the microbiota and immune system to influence health and disease remain unclear, especially in humans where these connections have been scarcely explored. This review seeks to summarize recent advances on the complex interaction of flavanols with gut microbiota, immunity and inflammation focus on metabolic diseases.

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Section: Metabolic Diseasesmentioning

confidence: 99%

Section: Metabolic Diseasesmentioning

confidence: 99%

Section: Metabolic Diseasesmentioning

confidence: 99%

Section: Metabolic Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Dietary Flavanols on Microbiota, Immunity and Inflammation in Metabolic Diseases

Martín

Ramos

2021

Nutrients

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Effects of marine phenolics on diabetes, obesity, and metabolic syndrome

García-Díez¹,

Ramos²

2023

Marine Phenolic Compounds

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Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Ramos

2021

Cells

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Type 2 diabetes (T2D) and obesity are relevant worldwide chronic diseases. A common complication in both pathologies is the dysregulation of the insulin-signaling pathway that is crucial to maintain an accurate glucose homeostasis. Flavonoids are naturally occurring phenolic compounds abundant in fruits, vegetables and seeds. Rising evidence supports a role for the flavonoids against T2D and obesity, and at present, these compounds are considered as important potential chemopreventive agents. This review summarizes in vitro and in vivo studies providing data related to the effects of flavonoids and flavonoid-rich foods on the modulation of the insulin route during T2D and obesity. Notably, few human studies have evaluated the regulatory effect of these phenolic compounds at molecular level on the insulin pathway. In this context, it is also important to note that the mechanism of action for the flavonoids is not fully characterized and that a proper dosage to obtain a beneficial effect on health has not been defined yet. Further investigations will contribute to solve all these critical challenges and will enable the use of flavonoids to prevent, delay or support the treatment of T2D and obesity.

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Metabolic syndrome and lipid metabolism disorders: Molecular and biochemical aspects

Cited by 4 publications

References 30 publications

Impact of Dietary Flavanols on Microbiota, Immunity and Inflammation in Metabolic Diseases

Impact of Dietary Flavanols on Microbiota, Immunity and Inflammation in Metabolic Diseases

Effects of marine phenolics on diabetes, obesity, and metabolic syndrome

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

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