Metabolic syndrome and its components associated with chronic kidney disease

Maleki, Ali; Montazeri, Mahdi; Rashidi, Negin; Montazeri, Mohammad; Yousefi-Abdolmaleki, Elham

doi:10.4103/1735-1995.163969

Cited by 12 publications

(5 citation statements)

References 32 publications

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“…This result reflects greater adherence to the lifestyle changes in the initial phases of the intervention, but the overall reductions in caloric intake and increased energy expenditures throughout the study may have resulted in sustained improved metabolic parameters and greater renal blood flow. Previous studies have shown improved renal hemodynamics following weight loss, including increased renal profusion and decreased systemic hypertension [25]. Weight loss has also been shown to reduce microalbuminuria and proteinuria that can lead to glomerular basement membrane damage and fibrosis [3,[26][27].…”

Section: Discussionmentioning

confidence: 99%

Impact of a Community-Based Weight Loss Program on Renal Function

Schwasinger-Schmidt

Elhomsy

Paull-Forney

2020

Cureus

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Introduction Obesity is associated with increased morbidity and mortality and is an independent risk factor for the development and progression of chronic kidney disease (CKD). This study investigated the effect of a community-based, lifestyle-focused, weight-loss intervention on renal function among participants at baseline following 12 weeks of therapy. Methods A retrospective analysis of adults enrolled in a weight management program from 2009 to 2014 was conducted. Participants consumed at least 800 kilocalories per day in meal replacements, attended weekly behavioral education classes, and expended approximately 300 kilocalories per day in physical activity. The primary outcome was the association of weight loss and changes in glomerular filtration rate (GFR). Secondary outcomes included changes in blood sugar levels, lipid parameters, blood pressure, and the use of medication for hypertension and diabetes mellitus. Results Of the 71 participants, 63.4% were female, the average weight was 289 pounds, the average body mass index (BMI) of 53, and baseline GFR 47 ml/min/1.73m 2. Following 12 weeks of the intervention, 76.1% of participants improved in CKD stage, 22.4% remained within the same stage, and 1.5% progressed to a higher stage (3A to 3B). Analysis revealed a correlation between weight loss and improved GFR (p=0.0006). Improvements were noted in blood sugar levels, blood pressure, and lipids (p<0.05). Medications were reduced in 61.8% of participants for hypertension and 83.3% for diabetes. Conclusions A significant correlation was observed between weight loss and improved renal function, with most participants improving in CKD stage. Participants also improved in markers of chronic disease and required fewer medications. When controlling for both diabetes and hypertension, the effect of improved renal function persisted.

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Section: Discussionmentioning

confidence: 99%

Impact of a Community-Based Weight Loss Program on Renal Function

Schwasinger-Schmidt

Elhomsy

Paull-Forney

2020

Cureus

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“…In Japan, Tozawa et al (29) Each component of metabolic syndrome can cause renal damage; however, the components may not contribute equally to the risk of developing CKD (25,31,32). Many studies have further reported the gradient associations between CKD risk and the number of components of metabolic syndrome (29,30,(32)(33)(34). The multiple mechanisms of renal damage caused by each metabolic syndrome component and their interactions with each other are not yet thoroughly understood.…”

Section: Discussionmentioning

confidence: 99%

“…Several other studies have reported similar results. Although metabolic syndrome itself is an independent risk factor associated with CKD, dyslipidemia (including both hypertriglyceridemia and low HDL-C level) is not significantly associated with the development of CKD (26,29,30,33,34,43). Some studies have shown that hypertriglyceridemia or low HDL-C levels are only significantly associated with the development of CKD in patients with metabolic syndrome (32,44).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Risk Factors Associated With Chronic Kidney Disease in a Middle-Aged and Elderly Taiwanese Population: A Cross-Sectional Study

Chen

Hsu

et al. 2021

Front. Med.

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Background: This study aimed to quantify the proportion of participants with chronic kidney disease (CKD) and associated metabolic risk factors in a middle-aged and elderly population in Guishan District, Taoyuan City, Taiwan.Methods: This cross-sectional study enrolled residents aged 50–90 years living in one community. All participants received a standardized personal interview, including a structured questionnaire, anthropometric measurements, and blood samples collected for laboratory testing. CKD was defined as the presence of kidney damage (urine albumin-creatinine ratio ≥30 mg/g) or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. Multiple logistic regression models were used to evaluate the risk factors associated with CKD.Results: A total of 400 participants were enrolled. The overall proportion of participants with CKD was 20.5% (95% confidence interval [CI]: 16.54–24.46%). The proportions of participants with CKD among those aged 50–64, 65–74, and 75 years and over were 17.7, 18.8, and 35.7%, respectively (p = 0.01). Multiple logistic regression model revealed that elevated blood pressure (odds ratio [OR] = 2.23, 95% CI: 1.16–4.30), hyperglycemia (OR = 2.87, 95% CI: 1.64–5.00), hyperuricemia (OR = 1.38, 95% CI: 1.14–1.69), and metabolic syndrome (OR = 2.30, 95% CI: 1.31–4.06) were significantly associated with CKD.Conclusions: The prevalence of CKD in the study population was high. Hypertension, hyperglycemia, hyperuricemia, and metabolic syndrome are significantly associated with CKD in a middle-aged and elderly population in Taiwan.

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“…Встановлено розвиток нефропатії за різних форм метаболічного синдрому за рахунок ліпотоксичності, гіперглікемії, ендотоксинемії [8][9][10][11].…”

Section: вступunclassified

Renoprotective Action of Phytotherapy in Experimental Metabolic Syndrome

Stepan¹

2020

Clin. and experim. pathol.

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Вищий державний навчальний заклад України «Буковинський державний медичний університет», м. Чернівці Мета роботи-дослідити лікувально-профілактичну дію на нирки щурів з експериментальним метаболічним синдромом двох рослинних екстрактів: з виноградної вижимки та з деревини дуба. Матеріали та методи. Використовували екстракт «Виноградний» (водноспиртова витяжка з виноградної вичавки) і екстракт «Дубовий», що містить фенольні речовини з дуба. Досліди проведені на щурах, у яких відтворювали метаболічний синдром (МС) шляхом утримання щурів на високожировому раціоні, при відтворенні кишкового дисбактеріозу та імунодефіциту (за рахунок введення цитостатика). Екстракт «Виноградний» вводили з кормом, а екстракт «Дубовий»-із питною водою, обидва в дозі 50 мг сухих речовин на кг живої маси. Фітопрепарати вводили щодня протягом 40 днів. У сироватці крові визначали активність еластази, уреази, лізоциму та аланінамінотрансферази (АЛТ). У гомогенаті нирок визначали активність еластази, уреази, лізоциму, каталази і вміст малонового діальдегіду (МДА). За співвідношенням активності каталази і вмісту МДА розраховували антиоксидантно-прооксидантний індекс (АПІ), а за співвідношенням відносних активностей уреази і лізоциму-ступінь дисбіозу. Результати. Показано, що у щурів із МС у нирках збільшується активність еластази, уреази, вміст МДА і ступінь дисбіозу при зниженні активності лізоциму, каталази й індексу АПІ. У сироватці крові щурів із МС збільшується активність еластази, уреази, АЛТ і знижується активність лізоциму. Фітопрепарати знижували активність еластази, уреази, вміст МДА і ступінь дисбіозу, проте збільшували активність лізоциму, каталази й індекс АПІ; більш суттєвий ефект виявлено в екстракта «Дубовий». Висновки. При МС у нирках розвивається запально-дистрофічний процес, обумовлений системним запаленням і бактеріємією. Фітопрепарати, особливо «Дубовий», здійснюють ренопротекторний ефект.

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Metabolic syndrome and its components associated with chronic kidney disease

Cited by 12 publications

References 32 publications

Impact of a Community-Based Weight Loss Program on Renal Function

Impact of a Community-Based Weight Loss Program on Renal Function

Metabolic Risk Factors Associated With Chronic Kidney Disease in a Middle-Aged and Elderly Taiwanese Population: A Cross-Sectional Study

Renoprotective Action of Phytotherapy in Experimental Metabolic Syndrome

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