Metabolic syndrome and endometrial cancer risk

Rosato, Valentina; Zucchetto, Antonella; Bosetti, Cristina; Maso, Luigino Dal; Montella, Maurizio; Pelucchi, Claudio; Negri, Eva; Franceschi, Silvia; Vecchia, Carlo La

doi:10.1093/annonc/mdq464

Cited by 141 publications

(114 citation statements)

References 39 publications

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“…Endogenous estrogen exposure has also been cited. Direct associations between the metabolic syndrome and its individual components and endometrial cancer risk have been previously described [48]. Brancati, et al [39] reported that Blacks suffer a two-fold increased risk of diabetes when compared with Whites, even when controlling for the usual surrogates for obesity, BMI and waist-to-hip ratio.…”

Section: Discussionmentioning

confidence: 94%

Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment

Oliver

Enewold²,

Zhu

et al. 2011

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 94%

Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment

Oliver

Enewold²,

Zhu

et al. 2011

Gynecologic Oncology

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“…In diabetic patients, the increased levels of oestrogen and androgen and the decreasing level of progesterone are considered potentially carcinogenic conditions for the breast, endometrium and ovaries. Hyperinsulinism also indirectly produces changes in sex hormone-binding globulin (SHBG) levels, including increases in the levels of oestrogen [69]. High BMI (and hyperadiponectinemia) and non-alcoholic fatty liver may also increase circulating SHBG [70,71].…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

Hernandez

Pasupuleti

Benítes-Zapata

et al. 2015

European Journal of Cancer

132

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Aim: It has been suggested that chronic hyperinsulinemia from insulin resistance is involved in the etiology of endometrial cancer (EC). We performed a systematic review and meta-analysis to assess whether insulin resistance is associated with the risk of EC. Methods: We searched PubMed-Medline, Embase, Scopus, and Web of Science for articles published from database inception through 30th September 2014. We included all observational studies evaluating components defining insulin resistance in women with and without EC. Quality of the included studies was assessed by NewcastleeOttawa scale. Randomeffects models and inverse variance method were used to meta-analyze the association between insulin resistance components and EC. Results: Twenty-five studies satisfied our inclusion criteria. Fasting insulin levels (13 studies, n Z 4088) were higher in women with EC (mean difference [MD] 33.94 pmol/L, 95% confidence interval [CI] 15.04e52.85, p Z 0.0004). No differences were seen in postmenopausal versus pre-and postmenopausal subgroup analysis. Similarly, non-fasting/fasting C-peptide levels (five studies, n Z 1938) were also higher in women with EC (MD 0.14 nmol/L, 95% * Corresponding author: Research Center, School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Building F, Campus Villa, Avenida Alameda de San Marcos Cuadra 2 s/n, Chorrillos, Lima 9, Peru. Tel.: þ51 1 3133333x2730.E-mail addresses: adrianhernandezdiaz@gmail.com (A.V. Hernandez), lepiscean@gmail.com (V. Pasupuleti), vbeniteszapata@gmail. com (V.A. Benites-Zapata), tpriyaleela@gmail.com (P. Thota), abhishekdp@gmail.com (A. Deshpande), faustino.perez@unizar.es (F.R. Perez-Lopez).1 Contributed equally to the study.

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“…Originally, the concern regarding metabolic syndrome was primarily focused on its contribution to increased cardiovascular disease and type 2 diabetes mellitus risk. However, recent evidence has shown a carcinogenic role of the metabolic syndrome in certain types of cancer [6][7][8][9][10][11]. However to date, epidemiological studies on metabolic syndrome and gastroesophageal cancer are sparse.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and esophageal and gastric cancer

Lin

Ness-Jensen

Hveem

et al. 2015

Cancer Causes Control

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Background The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear. Methods This was a large nationwide cohort study based on data from 11 prospective population-based cohorts in Norway with long-term follow-up, the Cohort of Norway (CONOR) and the third Nord-Trøndelag Health Study (HUNT3). The metabolic syndrome was assessed by objective anthropometric and metabolic biochemical measures and was defined by the presence of at least three of the following five factors: increased waist circumference, elevated triglycerides, low highdensity lipoprotein cholesterol, hypertension and high glucose. Newly diagnosed cases of esophageal adenocarcinoma, esophageal squamous-cell carcinoma and gastric adenocarcinoma were identified from the Norwegian Cancer Registry. Hazard ratios (HRs) and 95 % confidence intervals (CIs) were estimated using Cox proportional hazard models with adjustment for potential confounders. Result Among 192,903 participants followed up for an average of 10.6 years, 62 developed esophageal adenocarcinoma, 64 had esophageal squamous-cell carcinoma and 373 had gastric adenocarcinoma. The metabolic syndrome was significantly associated with an increased risk of gastric adenocarcinoma (HR 1.44, 95 % CI 1.14-1.82), but not associated with esophageal adenocarcinoma (HR 1.32, 95 % CI 0.77-2.26) or esophageal squamous-cell carcinoma (HR 1.08, 95 % CI 0.64-1.83). Increased waist circumference was associated with an increased HR of esophageal adenocarcinoma (HR 2.48,. No significant association was found between any single component of the metabolic syndrome and risk of esophageal squamous-cell carcinoma. High waist circumference (HR 1.71, 95 % CI 1.05-2.80), hypertension (HR 2.41, 95 % CI 1.44-4.03) and non-fasting glucose (HR 1.74, 95 % CI 1.18-2.56) were also related to an increased risk of gastric adenocarcinoma in women, but not in men. Conclusion Metabolic syndrome was associated with an increased risk of gastric adenocarcinoma in women. Of the individual components of the metabolic syndrome, high waist circumference was positively associated with risk of esophageal adenocarcinoma. Positive associations were also observed for women between high waist circumference, hypertension, high non-fasting glucose and risk of gastric adenocarcinoma. However, further evidence is warranted due to the limited number of cases and the inability to effectively identify gastric cardia adenocarcinoma.

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Metabolic syndrome and endometrial cancer risk

Abstract: This study indicates a direct association between various MetS components, besides overweight, with the risk of endometrial cancer.

Cited by 141 publications

References 39 publications

Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment

Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment

Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

Metabolic syndrome and esophageal and gastric cancer

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