Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Jung, Jun‐Sub; Kwon, Do Young; Han, Changsu; Park, Moon Ho

doi:10.5551/jat.18655

Cited by 19 publications

(21 citation statements)

References 43 publications

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“…In the Young Finns Study cohort, patients with MetS at baseline had an accelerated C-IMTp during 6-years of follow-up compared with those without [60] (Table 7; supplementary material). Similar findings were reported in middle-aged Japanese women [69], in middle-aged men free of diabetes and CVD [70], in an elderly population [71] and in apparently healthy adults [72] followed for variable periods. In the population-based Tromsø Study, MetS at baseline was associated with C-IMTp during 13-years follow-up in subjects below 50 years of age at baseline [73].…”

Section: Metabolic Syndrome and C-imtpsupporting

confidence: 80%

Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression: Inferences from Observational Cohort Studies and Interventional Trials

Frigerio

Werba

Amato

et al. 2020

CPD

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In the present review, associations between traditional vascular risk factors (VRFs) and carotid intimamedial thickness progression (C-IMTp) as well as the effects of therapies for VRFs control on C-IMTp were appraised to infer causality between each VRF and C-IMTp. Cohort studies indicate that smoking, binge drinking, fatness, diabetes, hypertension and hypercholesterolemia are associated with accelerated C-IMTp. An exception is physical activity, with mixed data. Interventions for the control of obesity, diabetes, hypertension and hypercholesterolemia decelerate C-IMTp. Conversely, scarce information is available regarding the effect of smoking cessation, stop of excessive alcohol intake and management of the metabolic syndrome. Altogether, these data support a causative role of several traditional VRFs on C-IMTp. Shortcomings in study design and/or ultrasonographic protocols may account for most negative studies, which underlines the importance of careful consideration of methodological aspects in investigations using C-IMTp as the outcome.

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Section: Metabolic Syndrome and C-imtpsupporting

confidence: 80%

Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression: Inferences from Observational Cohort Studies and Interventional Trials

Frigerio

Werba

Amato

et al. 2020

CPD

View full text Add to dashboard Cite

show abstract

“…Furthermore, the connection between early markers of atherosclerosis and metabolic conditions was related to the morpho-structural alteration in vascular beds to the systemic dysfunction of the human metabolism. In particular, Jung et al 35) observed that 370 patients (median age: 66 years), followed-up for at least 25 months and without any evidence of carotid atherosclerotic alterations (i.e., increased intima-media thickness and/or carotid plaque) at the enrolment phase, can early develop atherosclerotic plaques at carotid level in relation to the onset of metabolic syndrome. In particular, C-IMT, i.e., the change over time of the intima-media thickness of the carotid, was associated with metabolic syndrome onset at multivariate regression model.…”

Section: Resultsmentioning

confidence: 99%

Endothelial and Metabolic Function Interactions in Overweight/Obese Children:

Ciccone¹,

Faienza²,

Altomare³

et al. 2016

J Atheroscler Thromb

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“…20, 21 Matsui et al reported that the maximum home SBP was significantly associated with left ventricular mass index and IMT, and assessment of the maximum home SBP may increase the predictive value of hypertensive target organ damage in the heart and arteries. 22 It has been reported that the metabolic syndrome is associated with progression of early carotid atherosclerosis in the general population 23 and with subclinical atherosclerosis. 24 However, the association between IMT and the HbA1c value or the severity of diabetes mellitus is controversial.…”

Section: Resultsmentioning

confidence: 99%