Metabolic Syndrome and Cognitive Function: Cross-Sectional Study on Community-Dwelling Non-Demented Older Adults in Japan

Buyo, Momoko; Takahashi, Shun; Iwahara, Akihiko; Tsuji, Takao; Yamada, Shinichi; Hattori, Satoshi; Uematsu, Yoshihiko; Arita, Mikio; Ukai, Shigeo

doi:10.1007/s12603-020-1412-6

Cited by 14 publications

(16 citation statements)

References 29 publications

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“…The results from the cross-sectional Leiden 85-Plus Study showed no correlation of the TG concentrations with cognitive decline in 561 subjects aged ≥85 years [ 36 ]. Furthermore, in males, recent data from a cross-sectional study on 2150 Japanese participants (aged 60–90 years) found that high TG levels decrease the global cognitive impairment risk [ 37 ].…”

Section: Triglycerides and Different Types Of Cognitive Impairmentmentioning

confidence: 99%

The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence

Dimache¹,

Șalaru

Sascău

et al. 2021

Nutrients

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The burden of cognitive disorders is huge and still growing, however the etiology and the degree of cognitive impairment vary considerably. Neurodegenerative and vascular mechanisms were most frequently assessed in patients with dementia. Recent studies have shown the possible involvement of triglycerides levels in cognitive function through putative mechanisms such as brain blood barrier dysfunction or amyloid metabolism imbalance, but not all research in the field found this association. Several clinical studies evaluated the relationship between different forms of cognitive decline and levels of serum triglycerides, independent of other cardiovascular risk factors. This review focuses on the role of triglycerides in cognitive decline, cerebral amyloidosis and vascular impairment. Considering that the management of hypertriglyceridemia benefits from lifestyle modification, diet, and specific drug therapy, future studies are requested to appraise the triglycerides–cognitive impairment relationship.

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Section: Triglycerides and Different Types Of Cognitive Impairmentmentioning

confidence: 99%

The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence

Dimache¹,

Șalaru

Sascău

et al. 2021

Nutrients

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“…28 However, there have also been some studies that reported no significant association between global cognitive function and MetS. 15,16 In this study, MetS had no effect on global cognition status in the overall population. The mechanism for this relationship is not clear, but it may be related to the nutritional and metabolic status of the population.…”

mentioning

confidence: 45%

“…Some studies have indicated that MetS was an independent risk factor for cognitive impairment, [12][13][14] while other studies reported that there were no significant relationships between MetS and global cognitive function, especially in low-income people. 15,16 Therefore, this study's purpose was to explore the associations between MetS and its components with cognition among low-income adults in Northern China.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Metabolic Syndrome and Cognitive Function: A Population-Based Study of Middle-Aged and Elderly Adults in Rural China

Zhan¹,

Wang²,

Liu³

et al. 2021

DMSO

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Introduction To explore the relationship between metabolic syndrome (MetS) and cognitive impairment in a low-income and low-education population. Methods All residents aged ≥45 years in a low-income population in Tianjin, China, were eligible to participate in this study. The Mini-Mental State Examination (MMSE) scale was used to conduct a preliminary screening and assessment of the participants’ cognitive statuses. The MMSE components are orientation, registration, attention and calculation, recall, and language. Results In this population, the prevalences of MetS and cognitive impairment were 54.1% and 44.5%, respectively. In the overall population, the registration score was 0.105 points lower in the elevated triglycerides (TG) group than in the normal TG group (β, −0.105; 95% confidence interval [CI]: −0.201, −0.010; P=0.030). In men, high TG was associated with registration scores that were 0.152 points lower than those in the normal TG group (95% CI: −0.281, −0.022; P=0.022), while larger WC and lower HDL-C had positive effects on cognitive scores (all P<0.05). However, in women, there were no significant differences between cognitive scores and MetS or its components. Conclusion In this population, first, TG had a great impact on cognition, even greater than the impact of MetS on cognition. Second, the impact of MetS components on cognition was more obvious in men, and not all of the effects were negative. Therefore, the effect of MetS on cognition may need to be analyzed separately for different populations, and it may be that the effect of a single component is greater than the overall effect. When formulating prevention strategies for cognitive impairments, population differences must also be taken into consideration.

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“…However, the combined contribution of these conditions in the early stages of deteriorating cognitive health remains unclear. MetS has been related to dysfunction in global cognition and executive function in some previous studies ( 7–9 ), but not in other studies ( 10 , 11 ). Yet, a possible link between MetS and other cognitive domains (eg, memory, language, visuospatial abilities) remains controversial ( 7 , 12 ).…”

mentioning

confidence: 75%

Metabolic Syndrome Is Associated With Poor Cognition: A Population-Based Study of 70-Year-Old Adults Without Dementia

Marseglia

Darin‐Mattsson

Skoog

et al. 2021

The Journals of Gerontology: Series A

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Background Individual conditions of metabolic syndrome (MetS) have been related to dementia, however, their combined impact on the preclinical stage is unknown. We investigated the associations between MetS and domain-specific cognitive function as well as the role of sociodemographic, cardiovascular, and genetic factors. Methods Within the Gothenburg H70 Birth Cohort Study-Birth cohort 1944, 1131 dementia-free participants (aged 70 years) were examined during 2014-2016. MetS (central obesity plus at least two factors [reduced HDL-cholesterol, elevated triglycerides, blood pressure, or blood glucose]) was identified according to the International Diabetes Federation criteria. Five cognitive domains (memory, attention/perceptual speed, executive function, verbal fluency, visuospatial abilities) were generated after z-standardizing raw scores from ten neuropsychological tests. Education, heart disease, claudication (indicating peripheral atherosclerosis), and apolipoprotein (APOE) genotype were ascertained by trained staff. Data were analyzed with linear regression models. Results Overall, 618 participants (55%) had MetS. In multi-adjusted linear regressions, MetS was related to poorer performance in attention/perceptual speed (β -0.14 [95% CI -0.25, -0.02]), executive function (β -0.12 [95% CI -0.23, -0.01]), and verbal fluency (β -0.19 [95% CI -0.30, -0.08]). These associations were present only among individuals who did not carry any APOE-ε4 allele or were highly educated. However, among those with MetS, high education was related to better cognitive performance. MetS together with comorbid heart disease or claudication was associated with even worse cognitive performance than each alone. Conclusions MetS is associated with poor attention/perceptual speed, executive function, and verbal fluency performance. Education, APOE-ε4 allele, and comorbid cardiovascular disease influenced the observed associations.

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Metabolic Syndrome and Cognitive Function: Cross-Sectional Study on Community-Dwelling Non-Demented Older Adults in Japan

Cited by 14 publications

References 29 publications

The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence

The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence

Relationship Between Metabolic Syndrome and Cognitive Function: A Population-Based Study of Middle-Aged and Elderly Adults in Rural China

Metabolic Syndrome Is Associated With Poor Cognition: A Population-Based Study of 70-Year-Old Adults Without Dementia

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