Metabolic Syndrome Is Associated With Poor Cognition: A Population-Based Study of 70-Year-Old Adults Without Dementia

Marseglia, Anna; Darin‐Mattsson, Alexander; Skoog, Johan; Rydén, Lina; Hadarsson-Bodin, Timothy; Kern, Silke; Sterner, Therese Rydberg; Shang, Ying; Zettergren, Anna; Westman, Eric; Skoog, Ingmar

doi:10.1093/gerona/glab195

Cited by 25 publications

(18 citation statements)

References 40 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decreased heme biosynthesis in erythroid cells then causes anemia ( 30 ). Previous studies also showed that thiamine deficiency induced anorexia by inhibiting the hypothalamic adenosine monophosphate-activated protein kinase signal pathway and disrupting neuroendocrine feedback control of food intake and energy metabolism, which may be related to malnutrition in AD patients ( 31 ). Although adults with vitamin B12 or folate deficiency can also present with megaloblastic anemias, our results suggest that anemia in AD patients may be caused by TDP reduction more than folate or B12 deficiency.…”

Section: Discussionmentioning

confidence: 99%

Association Between Blood Biochemical Factors Contributing to Cognitive Decline and B Vitamins in Patients With Alzheimer's Disease

et al. 2022

View full text Add to dashboard Cite

BackgroundMalnutrition, metabolism stress, inflammation, peripheral organs dysfunction, and B vitamins deficiency significantly contribute to the progression and mortality of Alzheimer's disease (AD). However, it is unclear which blood biochemical indicators are most closely related to cognitive decline and B vitamins deficiency (thiamine, folate, vitamin B12) in patients with AD.MethodsThis was a cross-sectional study of 206 AD patients recruited from six hospitals in China. Thiamine diphosphate (TDP), the bioactive form of thiamine, was measured by high-performance liquid chromatography fluoroscopy (HPLC) at a single center. Levels of biochemical indicators (except TDP) were measured by regular and standard laboratory tests in each hospital. Pearson's rank correlation analysis was used to assess relationships between B vitamins and biochemical indicators. T-test was used to compare the difference between ApoE ε4 and non-ApoE ε4 groups. Differences were considered statistically significant as P < 0.05.ResultsAmong the biochemical results, in AD population, malnutrition indicators (erythrocyte, hemoglobin, serum albumin, and total protein) were most significantly associated with cognitive function, as was free triiodothyronine (FT3) levels which had been observed in previous study. Malnutrition and FT3 levels depend on age but not apolipoprotein E (ApoE) genotype. Meanwhile, Among the B vitamins, TDP was the most significantly associated with malnutrition indicators and FT3.ConclusionOur results indicated that TDP reduction could be a modifiable risk factor for malnutrition and FT3 that contributed to cognitive decline in AD patients. Correcting thiamine metabolism could serve as an optional therapy target for AD treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Association Between Blood Biochemical Factors Contributing to Cognitive Decline and B Vitamins in Patients With Alzheimer's Disease

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Most subjects finished their education at secondary level or even before that. Higher education can negatively influence the association between MetS and cognitive decline [ 7 ]. Similar to most studies concerning MetS, we also focus on the older population.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers link MetS with a dysfunction in global cognition and increased dementia risk [ 3 , 4 , 5 , 6 ]. Nevertheless, there is no agreement on the specific domains that are impaired [ 7 ]. Many studies demonstrated a strong association between MetS and lower frontal lobe functions, such as executive functions attention and verbal fluency [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, there is no agreement on the specific domains that are impaired [ 7 ]. Many studies demonstrated a strong association between MetS and lower frontal lobe functions, such as executive functions attention and verbal fluency [ 7 , 8 , 9 , 10 ]. Some, however, failed to confirm this connection [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some, however, failed to confirm this connection [ 11 , 12 ]. When it comes to other core cognitive domains, including episodic memory, perceptual speed, or visuospatial abilities, there is even less consensus, as available research studies are not consistent with each other [ 7 , 13 ]. Metabolic risk factors, for instance, hypertension and diabetes, have been hypothesized to play a great role in the pathogenesis of Alzheimer’s disease (AD) and the development of vascular dementia [ 1 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Verbal Fluency in Metabolic Syndrome

2022

View full text Add to dashboard Cite

Metabolic syndrome (MetS) or otherwise insulin resistance (IR) is described as a cluster of several commonly occurring disorders, including abdominal obesity; lipids disorders, such as hypertriglyceridemia; and low levels of high-density-lipoprotein cholesterol (HDL-C), hypertension (≥130/85 mmHg), and carbohydrates disorders, such as impaired fasting glucose or diabetes mellitus type 2. Type 2 diabetes (T2DM) constitutes insulin resistance, which is a strong risk factor for strokes. Patients with MetS are often prone to cognitive decline. Metabolic risk factors, hypertension, and diabetes, amongst them, have been hypothesized to play a great role in the pathogenesis of Alzheimer’s disease (AD) and the development of vascular dementia. For neuropsychological diagnostic and theoretical purposes verbal fluency is defined as a cognitive function that facilitates information retrieval from memory. It engages executive control and other cognitive processes, such as selective attention, selective inhibition, mental set shifting, internal response generation, and self-monitoring, as well as imagination and psychomotor skills. A total of 90 subjects, divided into 2 groups, patients with MetS (45) and healthy controls (45), were assessed. A significant difference in performance was found between the patients and controls, both in the phonetic (p < 0.01) and semantic fluency trials (p < 0.001). The MetS patients produced less words in the letter K and animal categories. The analysis of descriptive statistics shows that the group of patients with metabolic syndrome generated fewer words in both the phonetic and semantic categories. Our study shows that there is an association between metabolic factors and the verbal fluency performance of MetS patients. This is true, especially for phonetic verbal fluency, which is traditionally connected with the frontal cortex. Lower switching signifies possible executive dysfunctions amongst people with MetS. Subjects with this condition generated more diverse words and created less standard associations. This further implies the existence of dysexecutive syndrome and the need for diagnosing patients in this direction and involving this group of people in therapy. The proper correction of MetS components may improve cognitive function.

show abstract

Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease

Hatch

Gao

et al. 2023

Human Brain Mapping

View full text Add to dashboard Cite

Metabolic illnesses (MET) are detrimental to brain integrity and are common comorbidities in patients with mental illnesses, including major depressive disorder (MDD). We quantified effects of MET on standard regional brain morphometric measures from 3D brain MRI as well as diffusion MRI in a large sample of UK BioBank participants. The pattern of regional effect sizes of MET in non‐psychiatric UKBB subjects was significantly correlated with the spatial profile of regional effects reported by the largest meta‐analyses in MDD but not in bipolar disorder, schizophrenia or Alzheimer's disease. We used a regional vulnerability index (RVI) for MET (RVI‐MET) to measure individual's brain similarity to the expected patterns in MET in the UK Biobank sample. Subjects with MET showed a higher effect size for RVI‐MET than for any of the individual brain measures. We replicated elevation of RVI‐MET in a sample of MDD participants with MET versus non‐MET. RVI‐MET scores were significantly correlated with the volume of white matter hyperintensities, a neurological consequence of MET and age, in both groups. Higher RVI‐MET in both samples was associated with obesity, tobacco smoking and frequent alcohol use but was unrelated to antidepressant use. In summary, MET effects on the brain were regionally specific and individual similarity to the pattern was more strongly associated with MET than any regional brain structural metric. Effects of MET overlapped with the reported brain differences in MDD, likely due to higher incidence of MET, smoking and alcohol use in subjects with MDD.

show abstract

Metabolic Syndrome Is Associated With Poor Cognition: A Population-Based Study of 70-Year-Old Adults Without Dementia

Cited by 25 publications

References 40 publications

Association Between Blood Biochemical Factors Contributing to Cognitive Decline and B Vitamins in Patients With Alzheimer's Disease

Association Between Blood Biochemical Factors Contributing to Cognitive Decline and B Vitamins in Patients With Alzheimer's Disease

Verbal Fluency in Metabolic Syndrome

Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease

Contact Info

Product

Resources

About