Metabolic syndrome among type 2 diabetic patients in Ethiopia: a cross-sectional study

Birarra, Mequanent Kassa; Gelayee, Dessalegn Asmelashe

doi:10.1186/s12872-018-0880-7

Cited by 39 publications

(51 citation statements)

References 41 publications

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“…One of the findings of the present study is the variability of the overall prevalence of MetS among the study participants according to IDF, WHO, harmonized, and NCEP-III diagnostic criteria which is 59.9%, 31.2%, 65.6%, and 70.1%. A study from Gonder, Ethiopia observed a prevalence of 70.3%, 57%, and 45.3% by NCEP-ATP III, IDF, and WHO criteria, respectively,18 which is relatively comparable with our study. The variation on the prevalence of MetS among these different criteria was observed by other previous studies that compare different MetS diagnostic criteria 17,19.…”

Section: Discussionsupporting

confidence: 90%

<p>A Comparative Prevalence Of Metabolic Syndrome Among Type 2 Diabetes Mellitus Patients In Hawassa University Comprehensive Specialized Hospital Using Four Different Diagnostic Criteria</p>

Wube¹,

Nuru²,

Tesfaye³

2019

DMSO

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BackgroundRecognition of MetS in type two diabetic patients is important in starting the appropriate preventive and therapeutic measures. The commonly used definitions of MetS have similarities and discrepancies. Different definitions defined metabolic syndrome differently. IDF, WHO, NCEP-ATP III, and the harmonized definitions were used frequently to determine the prevalence of metabolic syndrome.ObjectivesThis study was aimed to investigate the prevalence of MetS and its associated factors among patients with type 2 Diabetes Mellitus using four definitions and to identify the concordance and the difference of these four definitions.MethodsA cross-sectional study was conducted from February 28 to May 30/2017 at Hawassa university comprehensive specialized hospital. The study involved 314 study participants selected by simple random sampling technique. Logistic regression was used to determine associated factors of metabolic syndrome, and kappa statistics was used to determine the concordance between different definitions of metabolic syndrome. In any cases, a p-value of <0.05 was considered to be statistically significant.ResultThe prevalence of metabolic syndrome according to IDF, WHO, harmonized, and NCEP-ATP III diagnostic criteria was 59.9%, 31.2%, 65.6%, and 70.1%, respectively. Our study found the maximum agreement between IDF and NCEP criteria (K=0.54, P<0.001) and IDF and Harmonized(K=0.65, P<0.001). Uric acid level was associated factor of metabolic syndrome by all the four definitions, and total cholesterol was associated factors by the three definitions.ConclusionThe prevalence of metabolic syndrome varies based on the definition used and the highest prevalence of MetS was observed with NCEP-ATP III and the different types of criteria do not always diagnose the same group of individuals.

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Section: Discussionsupporting

confidence: 90%

<p>A Comparative Prevalence Of Metabolic Syndrome Among Type 2 Diabetes Mellitus Patients In Hawassa University Comprehensive Specialized Hospital Using Four Different Diagnostic Criteria</p>

Wube¹,

Nuru²,

Tesfaye³

2019

DMSO

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“…The prevalence of MetS in our Malaysian patients with T2D as defined by revised NCEP ATP III criteria was higher than that reported in Ethiopians [28], Nepalese [29], Iranian [30], sub-Saharan Africans [31]; White, Black, and Mexican Americans [32]. On the other hand, a lower prevalence of MetS 45.8 and 28% was reported from India using NCEP ATP III and IDF criteria, respectively [9], and Ghana 43.83% according to NCEP ATP III and 69.14% by IDF criteria [33].…”

Section: Discussioncontrasting

confidence: 81%

Relationship of metabolic syndrome defined by IDF or revised NCEP ATP III with glycemic control among Malaysians with Type 2 Diabetes

Saif-Ali

Kamaruddin

Al‐Habori

et al. 2020

Diabetol Metab Syndr

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Background: The chronic complications of Type 2 Diabetes (T2D) such as macrovascular disease is amplified with the increase in the number of metabolic syndrome (MetS) risk factors. This research aims to study the relationship of MetS, diagnosed by the International Diabetes Federation (IDF) or revised National Cholesterol Education Programs Adult Treatment Panel III (NCEP ATP III) criteria, with glycemic control, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), C-peptide, and insulin resistance in T2D patients. Methods: The study is a cross-sectional observational study which, involved 485 T2D patients who are receiving treatment at the University Kebangsaan Malaysia Medical Center (UKMMC), Kuala Lumpur, Malaysia. The MetS among the T2D patients was diagnosed based on IDF and revised NCEP ATP III criteria. C-peptide and HbA1c levels were determined by an automated quantitative immunoassay analyzer and high-performance liquid chromatography, respectively. The MetS factors; FBG, triglyceride, and high-density lipoprotein cholesterol were measured by spectrophotometer. Results: Application of the IDF and revised NCEP ATP III criteria respectively resulted in 73% and 85% of the T2D subjects being diagnosed with MetS. The concordance of these criteria in diagnosing MetS among T2D patients was low (κ = 0.33, P < 0.001). Both IDF and revised NCEP ATP III criteria indicated that T2D patients with 5 MetS factors had higher insulin resistance (P = 2.1 × 10 −13 ; 1.4 × 10 −11), C-peptide (P = 1.21 × 10 −13 ; 4.1 × 10 −11), FBG (P = 0.01; 0.021), and HbA1c (P = 0.039; 0.018) than those T2D patients without MetS, respectively. Conclusion: Although there is a low concordance between IDF and revised NCEP ATP III criteria in the diagnosis of MetS among T2D patients, both criteria showed that T2D patients with 5 MetS factors had higher insulin resistance, C-peptide, FBG, and HbA1c.

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“…The prevalence of MetS in our Malaysian T2D de ned by IDF was similar to that reported in Ethiopians [28], Nepalese [29], Iranian [30], sub-Saharan Africans [31], and White American (70%) but higher than the Black (65%) and Mexican Americans (62%) [32] even though NCEP criteria were used in their study. On the other hand, a lower prevalence of MetS was reported from India 45.8, 57.7 and 28% using NCEP-ATP III, WHO and IDF criteria respectively [9] and Ghana 43.83% with NCEP-ATP III, 63.58% with WHO, and 69.14% with IDF criteria [34].…”

Section: Discussionsupporting

confidence: 85%

Relationship of Metabolic Syndrome Defined by IDF or Revised NCEP with Glycemic Control among Malaysians with Type 2 Diabetes

Saif-Ali

Kamaruddin²,

Al‐Habori

et al. 2020

Preprint

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Background Chronic complication of Type 2 Diabetes (T2D) such as macrovascular disease is amplified with the increase in the number of the metabolic syndrome (MetS) risk factors. Specific criteria for diagnosis of MetS are essential to help in glycemic control and reduce cardiovascular morbidity and mortality in diabetic patients with metabolic syndrome.Methods The study is cross-sectional observational study which involved 485 T2D patients who are receiving treatment at the University Kebangsaan Malaysia Medical Center (UKMMC), Kuala Lumpur, Malaysia. Metabolic syndrome among the T2D patients was diagnosed based on IDF and NCEP-R criteria. C-peptide and glycated hemoglobin (HbA1c) levels were determined by an automated quantitative immunoassay analyzer and high-performance liquid chromatography, respectively. The metabolic syndrome factors, glucose, triglyceride and HDL cholesterol were measured by spectrophotometer Results Application of IDF and NCEP-R criteria respectively resulted in 73% and 85% of T2D subjects being diagnosed with MetS. The concordance of these criteria in diagnosing MetS among T2D was low (κ =0.33, P<0.001). Both IDF and NCEP-R criteria indicated that T2D with five criteria of MetS had higher insulin resistance (P=2.1×10-13, P=1.4×10-11), C-peptide (P=1.21×10-13; 4.1×10-11), blood glucose (P=0.01; 0.021) and HbA1c (P=0.039; 0.018) than those T2D without MetS respectively. Conclusion Although, there is a low concordance between IDF and NCEP-R criteria in the diagnosis of MetS among T2D, both criteria showed that T2D with five criteria of MetS had higher insulin resistance, blood glucose and HbA1c.

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Metabolic syndrome among type 2 diabetic patients in Ethiopia: a cross-sectional study

Cited by 39 publications

References 41 publications

<p>A Comparative Prevalence Of Metabolic Syndrome Among Type 2 Diabetes Mellitus Patients In Hawassa University Comprehensive Specialized Hospital Using Four Different Diagnostic Criteria</p>

<p>A Comparative Prevalence Of Metabolic Syndrome Among Type 2 Diabetes Mellitus Patients In Hawassa University Comprehensive Specialized Hospital Using Four Different Diagnostic Criteria</p>

Relationship of metabolic syndrome defined by IDF or revised NCEP ATP III with glycemic control among Malaysians with Type 2 Diabetes

Relationship of Metabolic Syndrome Defined by IDF or Revised NCEP with Glycemic Control among Malaysians with Type 2 Diabetes

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