Metabolic studies with acetylcysteine

Sheffner, A. Leonard; Medler, E. M.; Bailey, K.R.; Gallo, Duane G.; Mueller, A. J.; Sarett, Herbert P.

doi:10.1016/0006-2952(66)90197-3

Cited by 86 publications

(44 citation statements)

References 10 publications

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“…875 NAC, N-acetylated cysteine, is a simple, nontoxic compound used against cystic fibrosis and coughing, capable of breaking disulfide bonds and dissolving mucus. 876,877 NAC can also act as a chelator 878 via some of its potential donor lone pairs on thiol, carboxylate, amine, and carbonyl. NAC is a membranepenetrable precursor to cysteine and is usually hydrolyzed to cysteine or forms disulfides with life times up to 6 h. 879 NAC has been shown to be beneficial in schizophrenia, possibly by inhibiting GABA-R, 880 and in various other neurological disorders.…”

Section: Natural Metal Chelators Againstmentioning

confidence: 99%

Bioinorganic Chemistry of Alzheimer’s Disease

2012

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Section: Natural Metal Chelators Againstmentioning

confidence: 99%

Bioinorganic Chemistry of Alzheimer’s Disease

2012

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“…NAC is rapidly absorbed after oral administration in both animals and humans [46][47][48]. The maximum plasma concentration is reached 2-3 h after administration [30] and the plasma half-life is 6.3 h. NAC undergoes extensive hepatic metabolism, resulting in a low bioavailability of y10% for the unchanged molecule.…”

Section: Clinical Pharmacologymentioning

confidence: 99%

Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease

Dekhuijzen¹

2004

European Respiratory Journal

269

186

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Oxidative stress has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease.Both reactive oxidant species from inhaled cigarette smoke and those endogenously formed by inflammatory cells constitute an increased intrapulmonary oxidant burden. Structural changes to essential components of the lung are caused by oxidative stress, contributing to irreversible damage of both parenchyma and airway walls. In addition, oxidative stress results in alterations in the local immune response, increasing the risk of infections and exacerbations, which, in turn, may accelerate lung function decline.The antioxidant N-acetylcysteine, a glutathione precursor, has been applied in these patients in order to reduce symptoms, exacerbations and the accelerated lung function decline. This article reviews the presently available experimental and clinical data on the antioxidative effects of N-acetylcysteine in chronic obstructive pulmonary disease.

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“…N-Acetyl-L-cysteine (L-NAC) and Lbuthionine-SR-sulfoximine (BSO) were from Sigma Chemical Co. (St. Louis, MO, USA). N-Acetyl-Dcysteine (D-NAC) was synthesized according to the method of Sheffner et al (8). In brief, D-NAC was chemically synthesized from D-cysteine and acetic anhydride.…”

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confidence: 99%

Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation

et al. 2004

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Abstract. We examined the effects of the stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on cellular glutathione (GSH) concentration and whether NAC-regulated cellular GSH levels are directly associated with angiotensin II (Ang II)-induced intracellular signaling events in vascular smooth muscle cells (VSMC). Both L-NAC and D-NAC similarly increased intracellular GSH concentration. We found that L-NAC and D-NAC both inhibited Ang IIinduced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and [ 3 H]-thymidine incorporation in VSMC. Our present study indicates the comparable effects of NAC stereoisomers in regulating intracellular GSH and the redox-dependent intracellular signaling mechanisms in VSMC.

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Metabolic studies with acetylcysteine

Cited by 86 publications

References 10 publications

Bioinorganic Chemistry of Alzheimer’s Disease

Bioinorganic Chemistry of Alzheimer’s Disease

Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease

Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation

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