Metabolic Studies in a Child with Ménière's Disease

Ménière's disease and plasmatic hyperosmolarity

“…(1) Alterations of serum electrolytes, generally by potassium, are present, but extremely rare (Talbott and Brown, 1940;Clayton et al, 1962;Weille, 1967). (2) Alteration of the acid-base equilibrium of the blood in the direction of alkalosis may be seen in a high percentage of cases (Weille, 1967;Celestino et al, 1969;Celestino and Iannetti, 1970).…”

Acid-base equilibrium in Menière's disease

“…Furstenberg et al (1934) claim that they constantly succeeded in reproducing the symptoms in 14 patients suffering from Meniere's disease by administering intravenously sodium bicarbonate. Perlman et al (1953), Golding-Wood (i960), Clayton et al (1962) report on the contrary negative results in this respect. The results of Golding-Wood seem the most important because they concern 27 subjects treated in the same way as Furstenberg and others did.…”

“…These attacks ceased when the Addison's disease was adequately controlled and the electrolytes were stabilized. Clayton et al (1962) were able to ascertain, by a systematic control of a patient suffering from Meniere's disease, that the attacks of vertigo were preceded by an increase of kalaemia and a reduction of natraemia.…”