Metabolic Score for Visceral Fat: a novel predictor for the risk of type 2 diabetes mellitus

Feng, Yifei; Yang, Xingjin; Yang, Li; Wu, Yuying; Han, Minghui; Qie, Ranran; Huang, Shengbing; Wu, Xiaoyan; Zhang, Yanyan; Zhang, Jinli; Hu, Huifang; Yuan, Lijun; Li, Tianze; Liu, Dechen; Hu, Fulan; Zhang, Ming; Zeng, Yunhong; Luo, Xinping; Lu, Jie; Sun, Liang; Hu, Dongsheng; Zhao, Yang

doi:10.1017/s0007114521004116

Cited by 15 publications

(16 citation statements)

References 47 publications

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“… 31 A cohort study from Henan (China), revealed METS-VF to be positively correlated with the risk of hypertension and type-2 diabetes mellitus. 32 , 33 In our study, with an increase in METS-VF quartile, CKD risk increased gradually, reaching 29.19% in Q4. Compared with Q1, the CKD risk increased by 3.04-times in Q4.…”

Section: Discussionsupporting

confidence: 51%

Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

Feng¹,

Chen²,

Wang³

et al. 2022

DMSO

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Purpose Metabolic disorders are closely related to the occurrence and development of chronic kidney disease (CKD). We explored the prospective association between the Metabolic Score for Visceral Fat (METS-VF) and CKD in a 5-year follow-up study. Patients and Methods In this cohort study, 631 adults not suffering from CKD from Wanzhai Town, in China in 2012 were included at baseline and followed up in 2017 and 2018. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between METS-VF and CKD risk. Area under the receiver operating characteristic curve (AUC) analyses were used to evaluate the ability of METS-VF, waist-to-height ratio (WhtR), visceral adiposity index (VAI), homeostatic model assessment of insulin resistance (HOMA-IR), body mass index (BMI) to predict CKD risk. Results We identified 103 CKD cases during follow-up. After adjustment for confounding factors, comparing the lowest quartile of METS-VF, the OR (95% CI) of CKD risk in the highest quartile was 3.04 (1.39–6.64). The per Standard deviation (SD) increase in METS-VF was positively correlated with CKD risk. The AUC of METS-VF for predicting CKD risk was, in general, higher than that for WhtR, VAI, HOMA-IR, and BMI. Conclusion METS-VF may be an indicator for predicting CKD risk.

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Section: Discussionsupporting

confidence: 51%

Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

Feng¹,

Chen²,

Wang³

et al. 2022

DMSO

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“…In their study, Yu et al discovered that the METS-VF had a robust predictive capacity for chronic kidney disease (CKD) when in comparison to alternative evaluation markers of central adiposity [ 43 ]. Additionally, in comparison to other evaluation indicators of obesity, METS-VF demonstrates reliability and applicability as a predictor of hypertension and diabetes within the Chinese population [ 44 , 45 ]. A 36,876-person study found a favorable correlation between METS-VF and asthma [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating a novel surrogate indicator of adipose accumulation in relation to erectile dysfunction

Deng,

Ke,

Guo

2024

Lipids Health Dis

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Introduction Although previous studies have linked obesity and erectile dysfunction, the novel surrogate indicators of adipose accumulation are more essential and dependable factors to consider. Therefore, the primary objective of the current investigation was to examine and clarify the association between metabolic score for visceral fat (METS-VF) and erectile dysfunction. Methods Firstly, multivariate logistic regression analysis, smoothed curve fitting, and threshold effect analysis were employed to investigate the association between METS-VF and erectile dysfunction. Mediation analysis was also performed to evaluate the mediating role of homocysteine and inflammation. After that, subgroup analysis was carried out to examine the stability of the correlation of METS-VF with erectile dysfunction in various population settings. Furthermore, the area under the receiver operating characteristic (ROC) curve and eXtreme Gradient Boosting (XGBoost) algorithm were utilized to assess the capability of identifying METS-VF in comparison to the other four obesity-related indicators in identifying erectile dysfunction. Results After adjusting for all confounding factors, METS-VF was strongly and favourablely correlated with erectile dysfunction. With each additional unit rise in METS-VF, the prevalence of erectile dysfunction increased by 141%. A J-shaped relationship between METS-VF and erectile dysfunction was discovered through smoothed curve fitting. Marital status, physical activity, and smoking status can potentially modify this association. This finding of the ROC curve suggests that METS-VF had a powerful identifying capacity for erectile dysfunction (AUC = 0.7351). Homocysteine and inflammation mediated 4.24% and 2.81%, respectively. Conclusion The findings of the current investigation suggest that METS-VF can be considered a dependable identifying indicator of erectile dysfunction.

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“…Moreover, the METS-VF was reported to have the ability to provide relatively accurate measurements of visceral adiposity and insulin resistance even in metabolically healthy obese individuals who do not have substantial laboratory disturbances ( 17 ). Meanwhile, the METS-VF has been demonstrated to be a strong predictor for hypertension and diabetes in Western and Chinese populations, and has stronger predictive power than several of the abovementioned indices ( 17 , 32 , 33 ). Overall, these characteristics and advantages of the METS-VF may facilitate its use in CKD risk prediction.…”

Section: Discussionmentioning

confidence: 99%

Association between metabolic scores for visceral fat and chronic kidney disease: A cross-sectional study

Meng

Kan

et al. 2022

Front. Endocrinol.

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IntroductionCentral obesity is closely linked to the risk of chronic kidney disease (CKD). This study aimed to evaluate the association between the novel central obesity index- metabolic score for visceral fat (METS-VF) and the risk of CKD in a Chinese population, and to compare its ability to predict CKD with other central obesity indices including waist circumference (WC), waist-to-height ratio (WHtR), lipid accumulation product (LAP), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), and cardiometabolic index (CMI).MethodsThis cross-sectional study included 8866 individuals from China. Demographic information, lifestyle data, and medical history data were collected, and physical examinations, anthropometric measurements and laboratory tests were performed for each participant. CKD was defined as an estimated GFR< 60 ml/min/1.73m2. Multivariate logistic regression models were used to evaluate the association between the METS-VF and the prevalence of CKD. Receiver operating characteristic (ROC) analyses were performed to assess and compare the predictive abilities of the central obesity indices and determine the optimal cut-off points.ResultsA graded increase in the prevalence of CKD was observed with increasing METS-VF tertiles. Moreover, the METS-VF was independently associated with the risk of CKD after adjustment for current smoking, current drinking, physical activity level, diabetes, hypertension, CVD history and BMI. Compared with participants with a METS-VF in the lowest tertile, the multivariate-adjusted ORs and 95% CIs for participants with a METS-VF in the highest tertile were 3.943 (2.435-6.385) in the overall population, 3.585 (1.585-8.109) for men and 4.627 (2.485-8.616) for women. Significant interactions were found between the METS-VF and the risk of CKD by age (P value for interaction = 0.023). In ROC analysis, the METS-VF had a higher AUC value than other indices for predicting CKD in men and had comparable or higher AUC than other indices for women. For predicting CKD, the optimal cut-off value of the METS-VF was 6.891 for men and 6.744 for women. The METS-VF yielded the greatest Youden index among all indices for both sexes.ConclusionA higher METS-VF was independently associated with a greater risk of CKD. The METS-VF can be a useful clinical indicator for identifying CKD, as it had superior predictive power for CKD when compared with other central obesity indices.

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Metabolic Score for Visceral Fat: a novel predictor for the risk of type 2 diabetes mellitus

Cited by 15 publications

References 47 publications

Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

Investigating a novel surrogate indicator of adipose accumulation in relation to erectile dysfunction

Association between metabolic scores for visceral fat and chronic kidney disease: A cross-sectional study

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