Metabolic responses to prolonged starvation, food restriction, and refeeding in the brown trout, Salmo trutta: Oxidative stress and antioxidant defenses

Bayır, Abdulkadir; Sirkecioğlu, Ahmet; Bayır, Mehtap; Haliloğlu, H. İbrahim; Kocaman, Esat Mahmut; Aras, N. Mevlüt

doi:10.1016/j.cbpb.2011.04.008

Cited by 101 publications

(83 citation statements)

References 38 publications

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“…Through the regulation of catalases as well as other mechanisms, the SR modulates this equilibrium. Interestingly, nutrient starvation is associated with increased antioxidant defenses in several eukaryotic species, such as yeast, fish, and plants (71)(72)(73)(74). Although cellular responses to nutrient limitation are clearly very different between eukaryotic and prokaryotic organisms, starvation may be a universal stress signal that triggers protective antioxidant defense mechanisms necessary for long-term survival.…”

Section: Figmentioning

confidence: 99%

The Stringent Response Controls Catalases in Pseudomonas aeruginosa and Is Required for Hydrogen Peroxide and Antibiotic Tolerance

et al. 2013

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e Pseudomonas aeruginosa, a human opportunistic pathogen, possesses a number of antioxidant defense enzymes under the control of multiple regulatory systems. We recently reported that inactivation of the P. aeruginosa stringent response (SR), a starvation stress response controlled by the alarmone (p)ppGpp, caused impaired antioxidant defenses and antibiotic tolerance. Since catalases are key antioxidant enzymes in P. aeruginosa, we compared the levels of H 2 O 2 susceptibility and catalase activity in P. aeruginosa wild-type and ⌬relA ⌬spoT (⌬SR) mutant cells. We found that the SR was required for optimal catalase activity and mediated H 2 O 2 tolerance during both planktonic and biofilm growth. Upon amino acid starvation, induction of the SR upregulated catalase activity. Full expression of katA and katB also required the SR, and this regulation occurred through both RpoSindependent and RpoS-dependent mechanisms. Furthermore, overexpression of katA was sufficient to restore H 2 O 2 tolerance and to partially rescue the antibiotic tolerance of ⌬SR cells. All together, these results suggest that the SR regulates catalases and that this is an important mechanism in protecting nutrient-starved and biofilm bacteria from H 2 O 2 -and antibiotic-mediated killing.

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Section: Figmentioning

confidence: 99%

The Stringent Response Controls Catalases in Pseudomonas aeruginosa and Is Required for Hydrogen Peroxide and Antibiotic Tolerance

et al. 2013

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“…Many fish species are routinely affected in the wild by periods of starvation of a variable length (Pérez-Jiménez et al, 2007;Furné et al, 2009;Bayir et al, 2011). This situation has clear effects on their metabolism, being reflected in different responses mainly related to the type of substrates used to provide energy, the growth rates observed, and in the functionality of their digestive system (Jobling, 2001).…”

Section: Introductionmentioning

confidence: 99%

Starving/re-feeding processes induce metabolic modifications in thick-lipped grey mullet (Chelon labrosus, Risso 1827)

Pujante

Martos-Sitcha

Moyano

et al. 2015

Comparative Biochemistry and Physiology Part B: Biochemistry an

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The effects of starvation and re-feeding on metabolites and tissue composition, GH/IGF-I axis, and digestive enzyme activities in juvenile thick-lipped grey mullet (Chelon labrosus) were evaluated. Fish were divided into three feeding groups (n=72, 82.00±4.09 g initial body mass). The control group was fed 1% of their body mass once a day throughout the experiment with commercial pellets. The other two groups were deprived of feed for 21 days (starved), or re-fed for 7 days after 14 days of food deprivation (re-fed). Full-length cDNAs from pituitary GH and hepatic IGF-I were cloned by screening a cDNA library or by PCR techniques. Furthermore, changes in their mRNA expressions were assessed by real time PCR in specimens maintained under the different feeding patterns. Results showed a negative growth in starved and re-feeding groups. Starvation induced a significant increase in plasma triglycerides as well as a decrease in liver glucose and glycogen. Re-feeding increased plasma glucose, lactate and protein, as well as liver glucose and glycogen. In addition, starvation significantly increased pituitary GH expression, while re-feeding down-regulated it. No significant changes were observed in hepatic IGF-I expression in any dietary treatment. Digestive enzyme activities were not significantly affected either by starvation or by re-feeding. The results of the present work suggest that juveniles of the thick-lipped grey mullet may easily adjust their metabolism under situations characterized by a short-term starvation and re-feeding.

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“…Mechanisms of antioxidant defences in fish include the enzyme system doi: 10.17221/8583-VETMED and low molecular weight antioxidants, similar to those in mammals, although the specific isoforms of enzymes in various fish species have not been well identified (Di Giulio and Meyer 2008). In fish, changes in antioxidant defence enzyme activities can be influenced both by intrinsic factors (age, feeding behaviour, food consumption) and by extrinsic factors, such as toxins present in the water, seasonal and daily changes in dissolved oxygen and water temperature (Bayir et al 2011). In their natural habitats, fish often have periods of poor food supply as a result of lower environmental temperature, spawning, migration and reproduction (Furne et al 2009), and changes of these variables are accompanied with seasonal fluctuations.…”

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confidence: 99%

Assessment of oxidative stress in Flathead mullet (Mugil cephalus) and Gilthead sea bream (Sparus aurata)

Fazio¹,

Piccione²,

Saoca³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:In this work we compared two species of fish with different feeding habits: Flathead mullet (Mugil cephalus) and Gilthead sea bream (Sparus aurata). The aim of this study was to evaluate total oxidant status (TOS), total antioxidant capacity (TAC) and TOS/TAC ratio (OSI), in order to highlight the presence of any differences and correlations in these two different species of fish. Thirty adult fish of Mugil cephalus and thirty of Sparus aurata were used. From each fish 0.6 ml of blood was collected. TOS and TAC indicators were measured in serum obtained from samples previously clotted and centrifuged. Our results showed statistically significant differences between the two species in TAC. TOS and OSI did not show significant differences between Gilthead sea bream and Flathead mullet. A positive relationship between TOS and TAC was found in Flathead mullet (Mugil cephalus), and a negative relation between TOS and TAC in Gilthead sea bream (Sparus aurata). Our study indicates that the oxidative status and the relationship between total oxidant status (TOS) and total antioxidant capacity (TAC) in serum are probably dependent on the fish species and are affected by different feeding habits.Keywords: total oxidant status; total antioxidant capacity; teleost species; redox balance List of abbreviations FRAP = ferric reducing antioxidant potential, ROM = reactive oxygen metabolites, ROS = reactive oxygen species, TAC = total antioxidant capacity, TOS = total oxidant status, OSI = oxidative stress index (TOS/TAC ratio)

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Metabolic responses to prolonged starvation, food restriction, and refeeding in the brown trout, Salmo trutta: Oxidative stress and antioxidant defenses

Cited by 101 publications

References 38 publications

The Stringent Response Controls Catalases in Pseudomonas aeruginosa and Is Required for Hydrogen Peroxide and Antibiotic Tolerance

The Stringent Response Controls Catalases in Pseudomonas aeruginosa and Is Required for Hydrogen Peroxide and Antibiotic Tolerance

Starving/re-feeding processes induce metabolic modifications in thick-lipped grey mullet (Chelon labrosus, Risso 1827)

Assessment of oxidative stress in Flathead mullet (Mugil cephalus) and Gilthead sea bream (Sparus aurata)

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