Metabolic responses to a traditional Mexican diet compared with a commonly consumed US diet in women of Mexican descent: a randomized crossover feeding trial

Santiago‐Torres, Margarita; Kratz, Mario; Lampe, Johanna W.; Tapsoba, Jean de Dieu; Breymeyer, Kara L.; Levy, Lisa; Villaseñor, Adriana; Song, Xiaoling; Neuhouser, Marian L.

doi:10.3945/ajcn.115.119016

Cited by 58 publications

(72 citation statements)

References 55 publications

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“…These foods, including quelites, are also rich in folates, and a dietary folate intake lower than 300 µg/d has been associated with adiposity and insulin resistance in subjects with obesity [53]. Consistent with some of the metabolic effects of the regionalized GENOMEX diet are those of a controlled-feeding trial that assessed metabolic and inflammatory responses to a U.S. dietary pattern compared to a traditional Mexican diet in healthy women of Mexican descent [26]. The traditional Mexican diet improved insulin sensitivity (HOMA-IR), lowered serum concentrations of insulin-like growth factor-binding protein-3 (IGFBP-3), and tended to reduce concentrations of insulin-like growth factor-1 (IGF-1) under conditions of weight stability, while no difference in inflammatory response was revealed.…”

Section: Discussionmentioning

confidence: 93%

“…Notably, compared to a large number of studies examining the benefits of traditional diets such as the widely recommended Mediterranean diet [23,24], there are very few studies evaluating the health effects of the traditional Mexican diet [25][26][27]. Therefore, this study aimed first to evaluate the effects of a regionalized GENOMEX diet on biochemical and anthropometric parameters and, subsequently, their relationship with the genetic profile of DRAG polymorphisms in subjects with metabolic risk factors for obesity-related CD.…”

Section: Introductionmentioning

confidence: 99%

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A Regionalized Genome-Based Mexican Diet Improves Anthropometric and Metabolic Parameters in Subjects at Risk for Obesity-Related Chronic Diseases

et al. 2020

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Obesity-related chronic diseases (CD) are highly prevalent in Mexicans who show moderate to high frequencies of diet-related adaptive gene (DRAG) polymorphisms and recent shifts in traditional dietary habits and lifestyles. This study first evaluated the effects of a regionalized genome-based Mexican (GENOMEX) diet on anthropometric and biochemical parameters and, subsequently their relationship with the genetic profile of DRAG polymorphisms in subjects with metabolic risk factors for obesity-related CD. Thirty-seven eligible subjects underwent a 24-week dietary intervention with a GENOMEX diet. The DRAG polymorphisms were determined by an allelic discrimination real-time assay to evaluate their association with the clinical response to diet. The GENOMEX diet significantly improved anthropometric parameters such as total weight, body mass index, waist circumference, and body fat percentage, with an average weight loss of 6.6% (5.3 ± 5.3 kg). The frequency of subjects with insulin resistance, hypertriglyceridemia and elevated VLDL-c (48.5% vs. 24.2%, p = 0.041; 45.5% vs. 12.1%, p = 0.003; and 39.4% vs. 15.2%, p = 0.027, baseline vs. 24-weeks, respectively) was reduced. A more significant favorable effect in HOMA-IR and insulin was observed in MTHFR 677T adaptive allele carriers, but no other DRAG polymorphism was associated with clinical changes. The GENOMEX diet improved the metabolic risk factors for obesity-related CD. The recommendation and habitual consumption of a traditional Mexican diet based on knowledge of the population's genetic and cultural history may be effective in preventing current obesity-related CD.Abstract: Obesity-related chronic diseases (CD) are highly prevalent in Mexicans who show moderate to high frequencies of diet-related adaptive gene (DRAG) polymorphisms and recent shifts in traditional dietary habits and lifestyles. This study first evaluated the effects of a regionalized genome-based Mexican (GENOMEX) diet on anthropometric and biochemical parameters and, subsequently their relationship with the genetic profile of DRAG polymorphisms in subjects with metabolic risk factors for obesity-related CD. Thirty-seven eligible subjects underwent a 24-week dietary intervention with a GENOMEX diet. The DRAG polymorphisms were determined by an allelic discrimination real-time assay to evaluate their association with the clinical response to diet. The GENOMEX diet significantly improved anthropometric parameters such as total weight, body mass index, waist circumference, and body fat percentage, with an average weight loss of 6.6% (5.3 ± 5.3 kg). The frequency of subjects with insulin resistance, hypertriglyceridemia and elevated VLDL-c (48.5% vs. 24.2%, p = 0.041; 45.5% vs. 12.1%, p = 0.003; and 39.4% vs. 15.2%, p = 0.027, baseline vs. 24-weeks, respectively) was reduced. A more significant favorable effect in HOMA-IR and insulin was observed in MTHFR 677T adaptive allele carriers, but no other DRAG polymorphism was associated with clinical changes. The GENOMEX diet improved the metabolic risk ...

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

A Regionalized Genome-Based Mexican Diet Improves Anthropometric and Metabolic Parameters in Subjects at Risk for Obesity-Related Chronic Diseases

et al. 2020

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“…Starch is the major storage carbohydrate present in dried legumes, root vegetables, and cereals, such as corn. Increasing evidence shows associations between traditional dietary patterns that include corn products and decreased risk of noncommunicable diseases in the Mexican population (Santiago-Torres et al, 2016). Mexico has the highest per capita consumption of corn.…”

Section: Introductionmentioning

confidence: 99%

“…Mexican population eaten corn mainly as tortilla (325 g of tortilla per person per day) and other nixtamalized corn products (Rojas-Molina et al, 2007). Increasing evidence shows associations between traditional dietary patterns that include corn products and decreased risk of noncommunicable diseases in the Mexican population (Santiago-Torres et al, 2016). The presence of polyphenols (PP), resistant starch (RS), and nonstarch polysaccharides (NSP) in corn products makes these foods good candidates to qualify as functional foods, promoting health benefits (Bello-Perez, Osorio-D ıaz, Agama-Acevedo, & Gonzalez-Soto, 2016).…”

Section: Introductionmentioning

confidence: 99%

Gut metabolites associated with pH and antioxidant capacity during in vitro colonic fermentation of Mexican corn products

et al. 2018

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Background and objectives Food is the major factor driving the metabolism of the gut microbiota. In Mexico, nixtamalized corn products are widely consumed. Changes in antioxidant capacity (AOX) in 1,1‐Diphenyl‐2‐picrylhydrazyl (DPPH) and Ferric ion reducing antioxidant power (FRAP), pH values, short‐chain fatty acid concentration, and relative metabolite production during in vitro colonic fermentation of indigestible fractions (IF) isolated from Istmo Totopos (ITs), baked corn tortillas (BCTs), and traditional corn tortillas (TCTs) were analyzed. Findings The consumption of one piece (10 g) of any corn product may potentially maintain appreciable colonic antioxidant status (above 60 mmol TE) until 48 hr of fermentation. A portion of 10 g of corn products produces similar concentrations of acetic (3,050.43–4,181.47 mM), propionic (1,904.78–2,975.18 mM), and butyric acid (1,458.14–2,873.47 mM) at 12 hr of fermentation. Forty‐six volatile compounds were also detected by solid‐phase microextraction–gas chromatography–mass spectrometry (SPME–GC–MS), and six principal components were identified. Positive correlations were found between DPPH, acetic acid, propionic acid, and butyric acid. Conclusions Our results suggest the colonic fermentation potential to increase bioactive compounds and antioxidant activity hence suggesting improved gut health. Additional studies are required to evaluate their in vivo effects. Significance and novelty The study of traditional corn products will facilitate a better understanding of the potential health‐promoting impact of the interactions between indigestible components of the Mexican diet and the gut metabolites.

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“…In another trial the metabolic changes to the traditional Mexican diet compared to a common US diet were investigated in women of Mexican descent in the USA [34]. …”

Section: Types Of Equity-relevant Trialsmentioning

confidence: 99%

Considerations and guidance in designing equity-relevant clinical trials

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Shea

et al. 2017

Int J Equity Health

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Health research has documented disparities in health and health outcomes within and between populations. When these disparities are unfair and avoidable they may be referred to as health inequities. Few trials attend to factors related to health inequities, and there is limited understanding about how to build consideration of health inequities into trials. Due consideration of health inequities is important to inform the design, conduct and reporting of trials so that research can build evidence to more effectively address health inequities and importantly, ensure that inequities are not aggravated. In this paper, we discuss approaches to integrating health equity-considerations in randomized trials by using the PROGRESS Plus framework (Place of residence, Race/ethnicity/culture/language, Occupation, Gender, Religion, Education, Socio-economic status, Social capital and “Plus” that includes other context specific factors) and cover: (i) formulation of research questions, (ii) two specific scenarios relevant to trials about health equity and (iii) describe how the PROGRESS Plus characteristics may influence trial design, conduct and analyses. This guidance is intended to support trialists designing equity-relevant trials and lead to better design, conduct, analyses and reporting, by addressing two main issues: how to avoid aggravating inequity among research participants and how to produce information that is useful to decision-makers who are concerned with health inequities.

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Metabolic responses to a traditional Mexican diet compared with a commonly consumed US diet in women of Mexican descent: a randomized crossover feeding trial

Cited by 58 publications

References 55 publications

A Regionalized Genome-Based Mexican Diet Improves Anthropometric and Metabolic Parameters in Subjects at Risk for Obesity-Related Chronic Diseases

A Regionalized Genome-Based Mexican Diet Improves Anthropometric and Metabolic Parameters in Subjects at Risk for Obesity-Related Chronic Diseases

Gut metabolites associated with pH and antioxidant capacity during in vitro colonic fermentation of Mexican corn products

Considerations and guidance in designing equity-relevant clinical trials

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