Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations

Hunt, Curtiss D.; Herbel, Jo L.; Nielsen, Forrest H.

doi:10.1093/ajcn/65.3.803

Cited by 111 publications

(53 citation statements)

References 25 publications

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“…Whereas, at the molecular level, Boron influences the activities of at least 26 enzymes (Hunt, 1998) and many of these enzymes are essential in energy substrate metabolism. In addition, it has been shown that Boron has many regulative roles in macromineral metabolism (Brown et al, 1989;Hegsted et al, 1991), energy metabolism (Hunt et al, 1997) and on the immune system (Hunt and Idso, 1999). Data of fructose concentration in seminal plasma (Table 1) revealed that there was a significant decrease in fructose concentration (p#0.05) after feeding bucks on different levels of boric acid compared to the control group.…”

Section: Results and Discussion Semen Characteristicsmentioning

confidence: 99%

“…The increase thyroid gland activity and its thyroxin hormone secretion in the Boron groups may be due to the effect of Boron on stimulate energy metabolism. According to Hunt et al (1997), Boron has many regulative roles in energy metabolism (Hunt et al, 1997), moreover, Boron influenced the activities of at least 26 enzymes (Hunt, 1998) and many of these enzymes are essential in energy substrate metabolism. Treating male rabbits with 100, 200 and 400 mg boric acid/kg feed boosted blood testosterone concentration to reach 23.6, 24.4 and 29.5%, respectively above the untreated group values which was not significant.…”

Section: Blood Biochemical Constituentsmentioning

confidence: 99%

“…In addition, it has been shown that Boron has many regulative roles in macromineral metabolism (Brown et al, 1989;Hegsted et al, 1991), energy metabolism (Hunt et al, 1997) and on the immune system (Hunt and Idso, 1999).…”

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Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Elkomy¹,

El-Hady²,

Elghalid³

2015

Asian J. of Poultry Science

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This study was carried out to assess the effect of Boron supplementation on male rabbit's reproductive performance. A total of 20 V. Line (V.L) adult rabbit bucks were divided into four equal experimental groups (5 bucks for each). Groups 2, 3 and 4 were fed rations supplemented with 17.5, 35 and 70 mg boron/kg feed in the form of boric acid (100, 200 and 400 mg boric acid, respectively) over 8 weeks. The first group was served as a control group. Results obtained by the Boron groups revealed that adding Boron to rabbit bucks rations at any tested doses resulted in a non-significant increase in the ejaculate volume of male rabbit by approximately 25% above the control group. Adding Boron at any dose exhibited a significant increase (p#0.01) in sperm concentration, total sperm output, sperm motility, live sperm and normal sperm compared to the control group and the high Boron dose had the highest effect on previous measurements compared to the low and medium Boron doses. Opposite trend was shown in the reaction time (libido) and seminal plasma fructose concentration which showed a significant decrease in these parameters in the Boron treated groups compared to the control. Plasma total protein, glucose, total lipids and triglycerides concentration were boosted in the Boron groups compared to the control (p#0.01) for glucose and triglycerides measurements. On the contrary, treated male rabbits with Boron at any tested doses resulted in a significant reduction in plasma cholesterol concentration. Blood and seminal plasma AST and ALT enzymes activities showed a tendency to decrease by Boron treatments compared to the control group. Treating bucks by different Boron doses resulted in a significant increase (p#0.01) in Total Antioxidant Capacity (TAC) to reach 110, 128 and 163% of blood plasma and 114, 121 and 122% of seminal plasma compared to the control value. On the other side, adding Boron to bucks rations did not affect the activity of seminal plasma alkaline phosphatase enzyme. Blood testosterone hormone had a tendency to increase in the Boron groups compared to the control group but this increase was not significant. It could be concluded that feeding rabbit bucks on rations containing the studied Boron doses results in a significant improvement in semen quality characteristics and had a positive effect on their physiological status.

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Section: Results and Discussion Semen Characteristicsmentioning

confidence: 99%

Section: Blood Biochemical Constituentsmentioning

confidence: 99%

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Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Elkomy¹,

El-Hady²,

Elghalid³

2015

Asian J. of Poultry Science

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“…It interacts with calcium, vitamin D, and magnesium, which are all important in bone metabolism. Boron also increases steroid hormone concentrations in postmenopausal women and has antioxidant properties, which could make it beneficial in preventing atherosclerosis (Hunt et al, 1997;Hunt, 1998;Devirian and Volpe, 2003). Recently, the Expert Committee on Trace Elements in Human Nutrition of the World Health Organization concluded that boron is probably essential in human nutrition (WHO, 1996).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Korkmaz

Uzgören

Bakırdere

et al. 2007

Environmental Toxicology

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Recent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boronrich rural areas, while 587 lived in relatively boron-poor regions. The average and standard deviation values for the age of the women screened with the cervical Pap smear test were 41.55 6 8.38. The mean dietary intake of boron was 8.41 mg/day for women from the boron-rich regions, and 1.26 mg/day for women living in the boron-poor regions (P < 0.0001). Women from the boron-rich regions had no cytopathological indications of cervical cancer, while there were cytopathological findings for 15 women from the boronpoor areas ( 2 ¼ 10.473, P < 0.05). Sixty women, 30 from each region, were chosen for evaluating MN frequencies in exfoliated buccal cells. MN frequencies for women from the boron-rich and boron-poor regions were not significantly different (t ¼ À0.294, P > 0.05). Also, there were no significant correlations between age and MN frequency for women from both the boron-rich (r ¼ 0.133, P ¼ 0.48, P > 0.05) and boron-poor (r ¼ À0.033, P ¼ 0.861, P > 0.05) regions. The results suggest that ingestion of boron in the drinking water decreases the incidence of cervical cancer-related histopathological findings. There was no correlation between the pathological findings from the cervical smears and buccal cell MN frequency suggesting that the two study populations were exposed equally to gentotoxic agents. Nonetheless, cervical cancer-related histopathological findings should be validated by other researchers. # 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 17-25, 2007.

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“…It increases steroid hormone concentrations and has antioxidant properties in postmenopausal women 9,11 . There is also evidence that B plays a role in healthy bones and joints 12,13 .…”

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confidence: 99%

Estimation of human daily boron exposure in a boron-rich area

Korkmaz

Şaylı²,

Sayli

et al. 2007

Br J Nutr

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Although, the safe limits of human daily boron (B) exposure are not absolutely clear, there is a growing interest in B and its effects on human health. The aim of the present study was to estimate daily B exposure in 66 males in Turkey living in a B-rich area using water containing at least 2 mg/l boron, with an average age of 38·55 (SE 1·66) years and an average number of years of residence in the B-rich area of 35·89 (SE 1·73). Another group of males (n 57), living in the city centres of Balıkesir and Ankara, were taken as controls; the average age and number of years of residence for this group were 29·44 (SE 1·43) and 10·26 (SE 1·83) years, respectively. As it is assumed that the B level in urine reflects daily B exposure, the amount of urinary B of both the study and control groups was analysed by using an inductively coupled plasma optical emission spectrometry (ICP-OES) technique. The average daily B exposure value was calculated as 6·77 (SE 0·47) mg in the study group and 1·26 (SE 0·1) mg in the controls. The results of this study are expected to contribute to creating a reference value for a safe daily B exposure. Boron: Daily exposure: Risk assessmentRecent studies conducted both in vitro and epidemiologically have indicated that boron (B) exposure may make significant contributions to human health 1 -3 . Humans are naturally exposed to B via food and drinking water 4 . B is absorbed almost completely by the gastrointestinal and respiratory system if exposure occurs, and is mostly present in body tissues and fluids as boric acid, B(OH) 3 , and in lesser amounts as B(OH) 4 2 anion 5 . Studies indicate that B homeostasis is basically maintained by urinary excretion 6 .B was defined as a trace element in 1980 7 . In spite of the lack of epidemiological data, the WHO reported that boron may provide a physiological benefit for human health 8 . Safe and/or beneficial B levels have not been determined for humans, though animal studies have defined deleterious and beneficial B levels for animals 9 .In a study by Penland 10 , it was outlined that B improves brain function and psychomotor response. It increases steroid hormone concentrations and has antioxidant properties in postmenopausal women 9,11 . There is also evidence that B plays a role in healthy bones and joints 12,13 . Additionally, in recent years there have also been some promising results concerning the treatment of certain malignancies 14,15 .Toxicological effects have also been reported in animals at higher doses, e.g in mice, rats and rabbits skeletal malformations and cardiovascular defects have been observed 16,17 . Although not confirmed, it was claimed that B had a deleterious effect in humans, the target organ being the testis. Atrophy and eventual degeneration of the organ in several animal species at high doses have been shown 18,19 . Initially, reproduction toxicology studies were based upon data obtained from animal studies and adapted to human risk evaluations 20 . It was reported in several field studies that B does not affect human r...

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Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations

Cited by 111 publications

References 25 publications

Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Estimation of human daily boron exposure in a boron-rich area

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