Metabolic recovery following temporary regional myocardial ischemia in the rat

Ibel, H.; Zimmer, Heinz‐Gerd

doi:10.1016/s0022-2828(86)80028-1

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…In the perfused rat hindquarter, supraphysiological concentrations of ribose (5 mM) enhanced the formation of phosphoribosyl pyrophosphate, a precursor of IMP production and, thereby, ATP synthesis (27). Furthermore, increasing ribose by intravenous ribose infusion was found to markedly enhance the recovery of myocardial ATP content as well as the functional capacity in various animal models of myocardial ischemia (11,13,16,22,23,26,(29)(30)(31).…”

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confidence: 96%

No effects of oral ribose supplementation on repeated maximal exercise and de novo ATP resynthesis

Eijnde

Leemputte

Brouns

et al. 2001

Journal of Applied Physiology

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A double-blind randomized study was performed to evaluate the effect of oral ribose supplementation on repeated maximal exercise and ATP recovery after intermittent maximal muscle contractions. Muscle power output was measured during dynamic knee extensions with the right leg on an isokinetic dynamometer before (pretest) and after (posttest) a 6-day training period in conjunction with ribose (R, 4 doses/day at 4 g/dose, n = 10) or placebo (P, n = 9) intake. The exercise protocol consisted of two bouts (A and B) of maximal contractions, separated by 15 s of rest. Bouts A and B consisted of 15 series of 12 contractions each, separated by a 60-min rest period. During the training period, the subjects performed the same exercise protocol twice per day, with 3-5 h of rest between exercise sessions. Blood samples were collected before and after bouts A and B and 24 h after bout B. Knee-extension power outputs were approximately 10% higher in the posttest than in the pretest but were similar between P and R for all contraction series. The exercise increased blood lactate and plasma ammonia concentrations (P < 0.05), with no significant differences between P and R at any time. After a 6-wk washout period, in a subgroup of subjects (n = 8), needle-biopsy samples were taken from the vastus lateralis before, immediately after, and 24 h after an exercise bout similar to the pretest. ATP and total adenine nucleotide content were decreased by approximately 25 and 20% immediately after and 24 h after exercise in P and R. Oral ribose supplementation with 4-g doses four times a day does not beneficially impact on postexercise muscle ATP recovery and maximal intermittent exercise performance.

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mentioning

confidence: 96%

No effects of oral ribose supplementation on repeated maximal exercise and de novo ATP resynthesis

Eijnde

Leemputte

Brouns

et al. 2001

Journal of Applied Physiology

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“…Various preclinical animal studies have consistently reported that a deficiency in myocardial ATP levels follows ischemia. This depletion in high-energy phosphates following ischemia has been investigated in isolated rat hearts and in a chronic canine model [40,41]. Ward and colleagues reported that there is an approximate 50% reduction in myocardial ATP levels following a moderate 20-minute global ischemic insult, for which an extended period of time is required for total recovery [9].…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effectiveness of a Food Supplement Containing Creatine and D-Ribose Combined with a Physical Exercise Program in Increasing Stress Tolerance in Patients with Ischemic Heart Disease

et al. 2019

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The aim of this study is to establish whether a supplement of creatine and ribose combined with a physical exercise program can improve the total work capacity during exercise in a population of patients with known ischemic heart disease. A double-blind, six-month study was designed in which 53 patients were enrolled and randomized to take either a nutraceutical composition containing creatine, D-ribose, vitamin B1, and vitamin B6 (active treatment) or the placebo. Both the nutraceutical supplement and the placebo were supplied by Giellepi S.p.A. Health Science in Lissone, Italy. After six months of study, the cardiac double product at the peak of the load, the delta double product, and the chronotropic index were higher in the active treatment group than in the placebo group. We can conclude that a supplementation with creatine, D-ribose, vitamin B1, and vitamin B6, in addition to standard therapy and a physical exercise program, seems to be helpful in improving exercise tolerance compared to the placebo in a population with cardiovascular disease. However, this needs to be further studied, given that there is no clear evidence that the double product can be used as a surrogate measure of exercise tolerance.

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“…Myocardial ischemia lowers ATP levels, resulting in reduced function, altered cellular homeostasis, and if severe, decreased myocardial viability [6,7]. This depletion in myocardial ATP levels following ischemia persists for hours to days due to slow adenine nucleotide synthesis [8,9]. The conversion of DR in the pentose phosphate pathway (PPP) can aid in producing high-energy phosphate compounds.…”

Section: Myocardial Adenine Nucleotidesmentioning

confidence: 99%