Metabolic Profile of Offspring from DiabeticWistarRats Treated withMentha piperita(Peppermint)

Abstract

This study aimed at evaluating glycemia and lipid profile of offspring from diabetic Wistar rats treated with Mentha piperita (peppermint) juice. Male offspring from nondiabetic dams (control group: 10 animals treated with water and 10 treated with peppermint juice) and from dams with streptozotocin-induced severe diabetes (diabetic group: 10 animals treated with water and 10 treated with peppermint juice) were used. They were treated during 30 days, and, after the treatment period, levels of glycemia, triglycerides, total cholesterol, and fractions were analyzed in the adult phase. The offspring from diabetic dams treated with peppermint showed significantly reduced levels of glucose, cholesterol, LDL-c, and triglycerides and significant increase in HDL-c levels. The use of the M. piperita juice has potential as culturally appropriate strategy to aid in the prevention of DM, dyslipidemia, and its complications.

Changes in the Content of Phenolic Compounds and Biological Activity in Traditional Mexican Herbal Infusions with Different Drying Methods

“…On the other hand, a trial was conducted with male offspring of non-diabetic mothers and mothers with severe streptozotocin-induced diabetes. It was found that the offspring of diabetic mothers, treated with mint, showed significantly reduced glucose levels [9]. However, the content of polyphenols, could participate in the glucose metabolism pathways related to the absorption of glucose in the intestine, the secretion of insulin by the β-cells of the islets, the regulation of liver glucose production, insulin receptor activity in insulin-sensitive tissues and glucose uptake, and regulation of intrahepatic glucose production [10].…”

“…Furthermore, the antioxidant activity of herbs and spices, associated with type 2 diabetes, may be a primary factor in vascular diseases that diabetics often develop [8]. Due to the different effects of advanced protein glycation in diabetes and the pathologies caused by age, it has been proposed that the inhibition of glycation can prevent the progression of different pathologies of diabetic complications and delay aging [9][10][11]. Therefore, studies have focused on the characterization of phenolic and other phytochemical compounds with biological activity, which are supplied to human organisms as food components or as specific preventive pharmaceutical products, and can improve glucose metabolism, as well as the general health of diabetic patients [12,13].…”

Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.)—A review

“…In a study of Barbalho et al (), the effect of peppermint leaf juice at a dose of 0.29 g/kg (100 g/L) on glucose tolerance level was studied in wistar non‐diabetic and streptozotocin (STZ) diabetic induced rats. Peppermint leaf juice (100 g/L) showed significantly reduced glucose, LDL‐c, cholesterol and triglycerides levels and significant rise in HDL‐c.…”

Some Medicinal Benefits of Psidium Guajava (Guava) and Portulaca oleracea

“…Studies have demonstrated that the consumption of fruits, vegetables, and seeds can be helpful to prevent the risk factors of many diseases due to the bioactive compounds. Many plants have been used for the purpose of reducing risk factors associated with the occurrence of chronic disorders and for many other purposes [12][13][14][15][16]. Psidium guajava L. is a small medicinal tree that is native to South America.…”