Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain

López-Sáez, Juan-Bosco; Martinez-Rubio, Jose Antonio; Alvarez, María; Carrera, Carmen Gonzalez; Dominguez‐Villar, Margarita; Mier, Antonio Garcia de Lomas; Doménech, Charo; Senra-Varela, Avelino

doi:10.2174/1874189400802010001

Cited by 13 publications

(9 citation statements)

References 23 publications

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“…Dyslipidemia often coexists with obesity and hyperinsulinemia. Few studies have explored the association between dyslipidemia and breast cancer risk [14,22], and in relation to breast cancer survival [11,36], although it has been suggested that dyslipidemia acts as a prognostic factor for breast cancer [35]. Our observation that total cholesterol was associated with overall breast cancer survival is supported [11].…”

Section: Discussionsupporting

confidence: 56%

“…Our observation that high BMI is related to adverse clinical outcomes in women with breast cancer is supported [1,3,[31][32][33] and challenging since systemic therapeutic regimens are often associated with weight gain [34] and, some suggest, dyslipidemia [35]. Moreover, obese premenopausal breast cancer patients have been observed to have more aggressive tumors than thin patients [1].…”

Section: Discussionmentioning

confidence: 78%

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Metabolic profile, physical activity, and mortality in breast cancer patients

Emaus

Veierød

Tretli

et al. 2009

Breast Cancer Res Treat

119

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Metabolic components [body mass index (BMI), blood pressure, serum lipids] and physical activity may affect biological mechanisms of importance for breast cancer prognosis. A population-based survival study among 1,364 breast cancer cases within the Norwegian Counties Study during 1974-2005 was conducted. Pre-diagnostic measurements of BMI, blood pressure, serum lipids, and self-reported physical activity were assessed. Multivariable Cox proportional hazard models were used in analyses (SAS version 9.11). Among these breast cancer cases (age at diagnosis 27-79 years), 429 women died (8.2 mean follow-up years). Those with a BMI >or= 30 kg/m(2) had a 1.47 higher risk of dying during follow-up than women with a BMI of 18.5-25 kg/m(2) [hazard ratio (HR) = 1.47, 95% CI 1.08-1.99]. Women with BMI < 25 kg/m(2) and age of diagnosis >or=55 years had a 66% reduction in overall mortality if they regularly exercised before diagnosis compared with sedentary women (HR = 0.34, 95% CI 0.16-0.71). Women in the highest tertile of total cholesterol had a 29% increase in mortality compared to women in the lowest tertile (HR = 1.29, 95% CI 1.01-1.64). Additionally, women in the highest tertile of blood pressure had a 41% increase in mortality compared to women in the lowest tertile of blood pressure (HR = 1.41, 95% CI 1.09-1.83). Our study supports a relationship between mortality not only in relation to BMI, but also blood pressure, lipids, and physical activity among breast cancer patients. These factors may all be important targets for invention among breast cancer patients.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 78%

Metabolic profile, physical activity, and mortality in breast cancer patients

Emaus

Veierød

Tretli

et al. 2009

Breast Cancer Res Treat

119

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“…Yet our findings of significantly higher levels of TC and LDL-c; and their menopausal status-wise distribution gain fair support from few previous studies. 5,8,19,20 The finding of lower serum HDL-c level in breast cancer subjects found in the present study is in line with results of earlier researches. 5,20,21 Though, whether the aberrations in serum lipid and lipoprotein levels are cause or effect of the disease still remains unclear; besides the fact that multiple hypotheses have been set forth till date; our study brings up with it certain alarming proclamation that post-menopausal lower HDL-c and/or increased serum TC and LDL-c during peri-and post-menopausal age have significant alliance with breast cancer, but serum total cholesterol may act as a constant menace throughout.…”

supporting

confidence: 92%

Menopausal dyslipoproteinemia in breast carcinoma patients: a laboratory analysis

Narkhede

Muddeshwar

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Seldom any precedent work has aimed to study the influence of age and menopausal status towards serum lipoproteins levels in breast cancer. Owing to influence of sex-steroids over lipid handling by oestrogen-dependent breast cells, their serum levels might reveal insinuating facts, if menopausal status-wise analysis is attempted. Ascertainment of serum lipid/lipoprotein aberrations in breast carcinoma; and substantiation of their behaviour with age and menopause among breast cancer and healthy subjects.Methods: Laboratory analyses of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low and very low density lipoproteins (LDL-c, VLDL-c) and triglycerides (TG) were done among breast cancer subjects (n=50) and healthy women (n=50) with respect to their age (3 sub-groups viz. 25-40, 41-55 and 56-75 years) and menopausal status. Grouped numerical data were subjected to intra- and inter-group comparisons using Student’s unpaired-‘t’-test and ANOVA with Post-Hoc comparisons using Tukey-HSD (Honestly-Significant-Difference) Test.Results: Higher serum LDL-c and TC with lower HDL-c levels were observed among breast carcinoma subjects than healthy women (P=0.004, 0.003, 0.009 respectively). Serum LDL-c elevation in peri- and post-menopausal age (P=0.009), while lowered HDL-c specifically during post-menopausal age (0.004) were significantly evident in breast cancer subjects.Conclusions: Breast carcinoma has obvious alliance with serum LDL-c, TC and HDL-c aberrations. LDL-c has specific variability during peri-menopausal and post-menopausal ages among breast cancer subjects. HDL-c alteration is mainly concerted for post-menopausal age; while total cholesterol could be a peril throughout. The odds of pooled effect of such aberrations in cancer causation cannot be underrated.

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“…As a result, BCS may develop CHD. A higher measurement of TC, LDL-C and TG was reported in BCS, when compared to non-BCS 7,8 . Furthermore, a relationship between obesity and unfavorable lipid profilehas been demonstrated in BCS 8,9 .…”

Section: Introductionmentioning

confidence: 82%

Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models

Sousa-e-Silva¹,

Conde²,

Martinez³

et al. 2014

Rev. Bras. Ginecol. Obstet.

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PURPOSE: It was to assess the risk of cardiovascular disease (CVD) in breast cancer survivors (BCS). METHODS:This cross-sectional study analyzed 67 BCS, aged 45-65 years, who underwent complete oncological treatment, but had not received hormone therapy, tamoxifen or aromatase inhibitors during the previous 6 months. Lipid profile and CVD risk were evaluated, the latter using the Framingham and Systematic COronary Risk Evaluation (SCORE) models. The agreement between cardiovascular risk models was analyzed by calculating a kappa coefficient and its 95% confidence interval (CI). RESULTS: Mean subject age was 53.2±6.0 years, with rates of obesity, hypertension, and dyslipidemia of 25, 34 and 90%, respectively. The most frequent lipid abnormalities were high total cholesterol (70%), high LDL-C (51%) and high non-HDL-C (48%) concentrations. Based on the Framingham score, 22% of the participants had a high risk for coronary artery disease. According to the SCORE model, 100 and 93% of the participants were at low risk for fatal CVD in populations at low and high risk, respectively, for CVD. The agreement between the Framingham and SCORE risk models was poor (kappa: 0.1; 95%CI 0.01-0.2) for populations at high risk for CVD. CONCLUSIONS: These findings indicate the need to include lipid profile and CVD risk assessment in the follow-up of BCS, focusing on adequate control of serum lipid concentrations. ResumoOBJETIVO: Avaliar o risco de doença cardiovascular (DCV) em mulheres com câncer de mama. MÉTODOS: Foi conduzido estudo de corte transversal, com 67 mulheres com câncer de mama, entre 45 e 65 anos, tratamento oncológico completo, não usuárias de terapia hormonal, tamoxifeno ou inibidores da aromatase nos últimos 6 meses. Foram avaliados o perfil lipídico e o risco de DCV. Para avaliar o risco de DCV, foram utilizados os modelos Framingham e Systematic COronary Risk Evaluation (SCORE). Para investigar a concordância entre os modelos de risco cardiovascular, foi calculado o coeficiente kappa com seu respectivo intervalo de confiança (IC) de 95%. RESULTADOS: A média de idade das participantes foi de 53,2±6,0 anos. A prevalência de obesidade, hipertensão e dislipidemia foi 25, 34 e 90%, respectivamente. A prevalência de dislipidemia foi 90%. As anormalidades mais comuns do perfil lipídico foram: alto colesterol total (70%), alto LDL-C (51%) e alto não HDL-C (48%). Baseado no escore de Framingham, 22% das mulheres com câncer de mama apresentaram alto risco de doença arterial coronariana. De acordo com o modelo SCORE, 100 e 93% das participantes apresentaram baixo risco de DCV fatal, considerando populações de baixo e alto risco de DCV, respectivamente. A concordância entre os modelos de Framingham e SCORE foi ruim (kappa: 0,1; IC95% 0,01-0,2), considerando populações de alto risco de DCV. CONCLUSÕES: Esses dados indicam a necessidade de incluir a avaliação do perfil lipídico e do risco de DCV na rotina de seguimento de mulheres com câncer de mama, sendo observadoo adequado controle dos níveis séricos de lipídios.

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Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain

Cited by 13 publications

References 23 publications

Metabolic profile, physical activity, and mortality in breast cancer patients

Metabolic profile, physical activity, and mortality in breast cancer patients

Menopausal dyslipoproteinemia in breast carcinoma patients: a laboratory analysis

Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models

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