Metabolic pathways enriched according to <scp>ERG</scp> status are associated with biochemical recurrence in Hispanic/Latino patients with prostate cancer

Acosta‐Vega, Natalia Lizeth; Varela, Rodolfo; Mesa, Jorge; Garai, Jone; Baddoo, Melody; Gómez, Alberto; Serrano-Gómez, Silvia J.; Lemus, Marcela Nuñez; Serrano, Martha Lucía; Zabaleta, Jovanny; Cómbita, Alba Lucía; Sanabria‐Salas, María Carolina

doi:10.1002/cam4.5301

Cited by 6 publications

(6 citation statements)

References 74 publications

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“…The grading system for the classification of patients, by the International Society of Urological Pathology in 2014, is a significant independent predictor of both biochemical recurrence and clinical recurrence after RP ( 60 ). In our previous study, we reported that Gleason GG2 and GG4/5 at RP were associated with the risk of BCR, compared to GG1 (p=0.037 and p=0.08, respectively) ( 38 ). We observed here that higher Gleason GG were associated with worse pathology and clinical features, as well as more cases having BCR within 5 years after RP.…”

Section: Discussionmentioning

confidence: 96%

“…This fragmentation can lead to delays in clinical interventions when patients transition between different health insurers and cancer institutes. Fourth, the small sample size and the inclusion criteria of patients, which focused on localized or regionally advanced PC who underwent RP [and with available tumor and non-tumor tissue samples for the study ( 38 )], might explain the low representation of higher Gleason GG and aggressive cases and may have limited the associations found in the analyses.…”

Section: Discussionmentioning

confidence: 99%

“…All AIMs were in Hardy-Weinberg equilibrium. Estimation of proportions of genetic ancestry was performed as previously described ( 38 ). For each case, the proportions of European, African, and Indigenous American ancestry were estimated under an admixture model with the ADMIXTURE ® software V1.3.0.…”

Section: Methodsmentioning

confidence: 99%

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Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients

Acosta-Vega,

Varela,

Mesa

et al. 2024

Front. Oncol.

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BackgroundAfrican ancestry is a known factor associated with the presentation and aggressiveness of prostate cancer (PC). Hispanic/Latino populations exhibit varying degrees of genetic admixture across Latin American countries, leading to diverse levels of African ancestry. However, it remains unclear whether genetic ancestry plays a role in the aggressiveness of PC in Hispanic/Latino patients. We explored the associations between genetic ancestry and the clinicopathological data in Hispanic/Latino PC patients from Colombia.Patients and methodsWe estimated the European, Indigenous and African genetic ancestry, of 230 Colombian patients with localized/regionally advanced PC through a validated panel for genotypification of 106 Ancestry Informative Markers. We examined the associations of the genetic ancestry components with the Gleason Grade Groups (GG) and the clinicopathological characteristics.ResultsNo association was observed between the genetic ancestry with the biochemical recurrence or Gleason GG; however, in a two groups comparison, there were statistically significant differences between GG3 and GG4/GG5 for European ancestry, with a higher mean ancestry proportion in GG4/GG5. A lower risk of being diagnosed at an advanced age was observed for patients with high African ancestry than those with low African ancestry patients (OR: 0.96, CI: 0.92-0.99, p=0.03).ConclusionOur findings revealed an increased risk of presentation of PC at an earlier age in patients with higher African ancestry compared to patients with lower African ancestry in our Hispanic/Latino patients.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients

Acosta-Vega,

Varela,

Mesa

et al. 2024

Front. Oncol.

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“…The human PCa bulk RNAseq data raw FASTQ files was collected from multiple cohorts. GEO accessions: GSE120795 57 , GSE126078 58 , GSE156289 59 , GSE114740, GSE217260, GSE179321 60 , GSE112786 61 , GSE104131 62 , GSE31528 63 , GSE54460 64 , GSE22260 65 , GSE216490 66 ; dbGaP accessions: phs000909.v1.p1 42 , phs000915.v2.p2 3 . The TCGA_PRAD read counts and TPM data were acquired using “recount3” 67 R package.…”

Section: Methodsmentioning

confidence: 99%

“…Eventually 877 high quality samples comprising normal, BPH, tumor, primary, AdPCa, CRPCa, mCRPCa, NEPCa, organoid, PDX (patient-derived xenograft) histology groups were selected and used for HuPSA-based deconvolution analysis. The FASTQ files were collected from multiple cohorts including GSE120795 49 , GSE126078 31 , GSE156289 50 , GSE114740, GSE217260, GSE179321 51 , GSE112786 52 , GSE104131 53 , GSE31528 54 , GSE54460 55 , GSE22260 56 , GSE216490 57 ; dbGaP accessions: phs000909.v1.p1 58 , phs000915.v2.p2 2 . The TCGA_PRAD read counts and TPM data were acquired using “recount3” 59 R package.…”

Section: Methodsmentioning

confidence: 99%

Unveiling Novel Double-Negative Prostate Cancer Subtypes Through Single-Cell RNA Sequencing Analysis

Cheng,

Li,

Yeh

et al. 2023

Preprint

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Androgen deprivation therapy has improved patient survival. Nevertheless, treatment resistance inevitably emerges due to the complex interplay of tumor heterogeneity and lineage plasticity. We integrated scRNAseq data from billions of cells, including both public cohorts and data generated in our laboratory, and generated the HuPSA (Human Prostate Single cell Atlas) and MoPSA (Mouse Prostate Single cell Atlas) datasets.Through unsupervised clustering and manually annotation, both atlases not only validated previously known prostate adenocarcinoma (AdPCa), neuroendocrine prostate cancer (NEPCa), stromal, and immune cell populations but also unearthed the less described populations including MMP7+ normal prostate club cells and two novel lineage plastic cancerous populations, namely progenitor-like and KRT7+ cells. Immunostaining experiments confirmed the presence of these populations in both human and mouse tissues, solidifying their significance in PCa biology. To unravel the drivers of these distinct cell populations, we calculated the upstream regulators of the genes enriched in these cells. Furthermore, leveraging the power of state-of-the-art bioinformatics analyses, we scrutinized over one thousand human PCa bulk RNAseq samples. Employing HuPSA-based deconvolution, we reclassified these samples into different molecular subtypes, including the newly discovered KRT7 and progenitor-like groups. The HuPSA and MoPSA provide invaluable blueprints for analyzing and interpreting external PCa single-cell RNAseq datasets. Our data elucidates the roadmap of PCa progression, showcasing the development of heterogeneous populations through lineage plasticity. This understanding holds promise for guiding the development of precise medicine in PCa field.

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Metabolic pathways enriched according to ERG status are associated with biochemical recurrence in Hispanic/Latino patients with prostate cancer

et al. 2022

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Metabolic pathways enriched according to ERG status are associated with biochemical recurrence in Hispanic/Latino patients with prostate cancer

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 74 publications

Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients

Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients

Unveiling Novel Double-Negative Prostate Cancer Subtypes Through Single-Cell RNA Sequencing Analysis

Metabolic pathways enriched according to ERG status are associated with biochemical recurrence in Hispanic/Latino patients with prostate cancer

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